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What is a Skin Microbiome? The first layer of defense for your skin against outside forces is made up of good bacteria. A diverse microbiome means healthy skin. The secrets behind your skin microbiome On the surface of your skin sits an organic ecosystem made up from billions of good bacteria called the microbiome. It forms the first layer of defense for your skin against outside forces. In order for your skin microbiome to be healthy, it must be balanced. A balanced microbiome means healthy skin What affects your skin microbiome? Your environment The country you live in can have adverse effects on your skin microbiome, from pollution levels to UV exposure. Your skin care routine When it comes to skin care, not knowing what products to use can negatively impact your skin microbiome. Your physical wellbeing What you put in your body is as important as what you put on it. A healthy diet can affect your skin health. Your mental health When you aren’t well internally, it can be a struggle to look after yourself. It is imperative to be aware of your mental health. Frequently asked questions What is your skin microbiome? Your skin microbiome is formed of the billions of microbes that sit on the surface of your skin but also line the gut, mouth, and other parts of the body. At Sequential Skin, we focus solely on your skin microbiome, testing it and providing you with solutions to balance it. Your microbiome is essential to your skin health and it is unique to you. What does it mean to have a balanced microbiome? Your skin microbiome health is measured by how equally dispersed the bacteria on your skin are compared to one another. When one or more bacteria dominate others, you might face skin conditions such as acne, rosacea, and eczema. Our test measures 20 microbes and provides you with a full report so you can transcend your skin to its optimal level. What affects your skin microbiome? The skin microbiome is largely impacted by your external environment, such as your location, pollution levels, and the skincare products that you use. This means that your skin is ever-changing and constantly adapting to different elements. It’s also influenced by internal factors, like gut health, making it unique to each of us. How can your skincare routine affect your skin microbiome? If you are using harsh ingredients that contain alcohol and irritants, it can severely disbalance your skin microbiome. You may think you are using products that are helping your skin, but instead, they are having adverse effects. This is why it is so important to test your skin microbiome and see if you might need a change of routine. Unearth the secrets of your skin microbiome We are skin experts We are a team of award-winning scientists with a mission to empower individuals to make better-informed decisions about their skin health. Our Story

The ingredient list for our Biome Mask formulation with each of their applications from giving deep hydration to protecting from pollutants with antioxidant benefits. Category Ingredient What is it? Benefit Melanin Targeters Arbutin Arbutin is an antioxidant that is extracted from different berries. Arbutin helps in ensuring that skin is brightened and pigmentation is reduced in the skin. It can also fade scars. Hydrators Squalane Squalane is a hydrogenated version of squalene. It is an emollient and behaves similar to our own skin sebum. Prevents moisture loss, can neutralize UV damage . Postbiotics Lactobacillus ferment Lactobacillus ferment is a non-living probiotic ingredient made by fermentation of the microorganism Lactobacillus. Thanks to its soothing effect on the skin, it helps to strengthen the skin's defense and maintains the health of the skin microbiome. Allantoin Allantoin is an extract from comfrey plant. Allantoin protects and soothes the skin. Trehalose Trehalose is a disaccharide with hydrating properties for the skin. It’s a plant sugar. Trehalose is used as a prebiotic and is effective to help maintain healthy skin. Green Tea Extract Extract from the leaves of green tea. Tea Extracts is an antioxidant ingredient that aids soothing the skin and can also address skin discoloration and early signs of aging. Colloidal Oatmeal Colloidal Oatmeal is cocktail of oats that has been refined into powder and acts as a skin protectant. Colloidal Oatmeal aids in locking in moisture in the skin barrier and also has soothing properties. Skin Soothing Multi-Ceramide [Ceramide NP; Phytosphingosine] Ceramides are lipids or fats that exist in skin cells and make up to 40% of your outer skin layer. Ceramides are crucial in aiding your skin to retain moisture and prevent unwanted bacteria from entering your body. Skin Repairing Peptide Complex [copper tripeptide-1, Acetyl heaxapeptide-8, Palmitoyl Pentapepdide-4, Palmitoyl tripeptide-1, Palmitoyl tetrapepide-7, tripeptide-1, tripeptide-2, tripeptide-2, tripeptide-3, acetyl Octapeptide 3] Peptides are amino acid chains that aid in the forming of certain types of protein in the skin such as elastin and collagen. Peptides can help in increasing skin elasticity and reducing signs of aging, allowing skin to appear firmer. Skin Shields Vitamin E [Tocopherol] Tocopherol is an excellent example of a powerful antioxidant that is oil-soluble, meaning it can easily dissolve into the skin. Tocopherol helps in combating free-radical damage (such as pollution), and can also be an effective hydrator. Retinyl Palmitate Retinyl Palmitate is the most abundantly used form of retinol (Vitamin A). Retinyl Palmitate has anti-aging properties as well as anti-oxidant properties. Centella Asiatica Centella Asiatica is a medicinal herb that is known to treat inflammation and has antioxidant properties. Centella Asiatica is used as an active ingredient in skincare products for anti-inflammation, anti-oxidant and soothes compromised skin.

Atopic dermatitis (AD), a chronic inflammatory skin condition, affects around 31.6 million people in the U.S., with 15-20% of children globally and 7.3% of U.S. adults experiencing the condition. TARGETED SKIN PANEL Atopic Dermatitis Targeted Panel 23 Smart Probes ™ Atopic Dermatitis Panel Validated targets: Staphylococcus aureus, Malassezia spp, Staphylococcus epidermidis Absolute Quantification End-to-end Service Qet a Quote Atopic Dermatitis Study with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for Atopic Dermatitis? Atopic dermatitis (AD), a chronic inflammatory skin condition, affects around 31.6 million people in the U.S., with 15-20% of children globally and 7.3% of U.S. adults experiencing the condition (National Eczema Association). AD often results from a combination of genetic predisposition and environmental triggers, such as irritants in cosmetic products. Disruptions to the skin’s microbiome play a significant role in the disease's development and severity. Imbalances in beneficial and harmful microbes can exacerbate AD, highlighting the importance of targeted treatments. In vivo testing for products aimed at managing AD is essential because it allows researchers to understand how formulations impact both the skin barrier and microbiome in real-world conditions. Properly tested products can help reduce irritation and avoid worsening symptoms, offering a science-backed approach to skincare for those with AD. Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of AD at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of AD-associated microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to AD-prone skin, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New AD treatments or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with AD development and severity. Smart Probe s ™ Our dedicated team of scientists has developed a revolutionary method for evaluating microbes through our Smart Probes™. This proprietary panel includes 23 key microbes that we have specifically identified as having the most significant impact on skin health. To further understand the intricate relationship between atopic dermatitis (AD) and the skin microbiome, we use qPCR technology. This advanced technique allows us to precisely quantify microbial populations on the skin, providing deeper insights into how AD affects the microbiome. By closely monitoring how products interact with both beneficial and harmful microbes, companies can create solutions for AD but also restore a healthy balance to the skin’s ecosystem. Atopic Dermatitis Panel Targets Staphylococcus aureus This bacterium is frequently found in higher numbers on the skin of individuals with atopic dermatitis. It can exacerbate inflammation and contribute to skin barrier disruption. Malassezia spp This genus of yeast, which is part of the normal skin flora, can become overgrown in individuals with atopic dermatitis, potentially aggravating symptoms. Staphylococcus epidermidis While generally considered a commensal organism, imbalances in its population, along with other microbes, can influence the skin's health and contribute to atopic dermatitis symptoms. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research Revolutionising Eczema Care: The Promise of Live Biotherapeutic Products AOB for AD: Ammonium-oxidising Bacteria as an Innovative Approach to Managing Atopic Dermatitis Answers for Atopic Dermatitis and Allergies: What is the Role of the Skin Bacteriome? Read More Articles

Throughout the year, Sequential has the pleasure of going to various conferences and trade shows where we talk all things microbiome testing and clinical studies. Don't miss us when we're in your city next! Connect With Us At Conferences At Sequential, we believe in the power of personal connections and the exchange of ideas to foster innovation and growth. As we actively participate in various conferences and industry events, we invite you to be a part of these enriching experiences. Explore the opportunities to engage with our team, discover the latest industry trends, and strengthen the bonds that drive mutual success. Join us at conferences to connect, learn, and pave the way for future collaborations. Where we will be in 2026 2-4 March Cambridge, United Kingdom 18-19 March Copenhagen, Denmark 14-16 April Paris, France 19-20 May New York City, USA 14 July Liverpool, United Kingdom 28 September - 1 October Perth, Australia 10-11 November Coventry, United Kingdom Microbiome Interactions in Health and Disease Our CEO & Co-founder, Dr. Oliver Worsley, will have the pleasure of attending this year. Microbiome Times Partnering Forum We are incredibly excited to be part of this forum, where we get to discuss with experts in the industry. In-cosmetics Global Have the pleasure of exhibiting and presenting at In-cosmetics Global. Come visit us at Booth (1A64) and listen to our CEO & Co-founder, Dr. Oliver Worsley, speak on “Advancing Personal Care Claims with integrated Human and Microbiome Data” on 14th April, Theatre 3 – 15.05 - 15.35. NYSCC Supplier's Day We are back at New York Supplier’s Day! (Booth information TBA) SCS Conference We will be attending the SCS Conference and look forward to connecting with industry peers. IFSCC Congress We are pleased to be attending the IFSCC Congress, engaging with the global cosmetics science community. SCS Formulate Visit us at Booth (600) at this year’s SCS Formulate to learn more about our work and speak with the team. Connect with us on Socials!

Certify your intimate care product with us! Maximize microbiome benefits in your strategy. Let's get started today for success! Vaginal & Vulvar Microbiome Testing As the intimate care industry grows, consumers demand transparency from the brands formulating their products. It has become essential for formulators to create products they are willing to test to present scientifically backed data-driven evidence of their products' true effects. Sequential offers microbiome testing for your intimate care formulations, hygiene washes and other products geared towards that delicate area. We are dedicated to understanding how your product interacts with the vaginal region and its microbes. Depending on how in-depth you want to go, we offer qPCR, 16S, ITS, and Shotgun Metagenomics. Download Case Study! Personalized Approach to Testing Unlike other methodologies present within the industry, Sequential's approach ensures that your product's data and analysis will stand the test of industry regulations when they are introduced. You can tailor your study entirely to your unique requirements. Test Products in a Real-Life Context The microbiome comprises a complex ecosystem of microorganisms that live together in a delicate balance, which is why it's best to test directly upon it directly. To fully understand the impact a product is having on the microbiome, in vivo is the only way. Collect Longitudinal Data With in vivo testing we can design your study around the extended use of a product over multiple time points. This allows us to review how a product is performing before and after usage, but also take into account its gradual impact on the microbiome. Measure Against a Control Group Measure a product against a control group that might have a different percentage of your active ingredient within its formulation or no active at all. This will allow for deeper insights into the impact of a formulation on microbial balance and diversity. 4 Sequencing Reports To Pick From Depending on your development stage and what you are interested in studying we offer qPCR, 16S, ITS, and Shotgun Metagenomics. With our qPCR Smart Probes™ we can go down to the strain level in our analysis. Personalize Your Microbiome Study! The vaginal microbiome is a dynamic ecosystem primarily dominated by Lactobacillus bacteria, which produce lactic acid and help maintain an acidic pH, creating a hostile environment for potential pathogens. This acidic environment is crucial for preventing infections and promoting overall vaginal health. Smart Probe s ™ Our dedicated team of scientists have developed a method of evaluating microbes through our Smart Probes ™ . These refer to a panel of 20 key microbes we have specifically identified as having the most impact on vaginal health. Over and above the taxonomic characterisation that 16S offers, which gives us a snapshot of all the genus present within a collected sample (Lactobacillus , Streptococcus , etc.) our targeted approach takes it a step further, opening the lens to the species (L.crispatus ), sub-species and even strains within them. This is a crucial distinction as not all strains of a species behave similarly. In fact, we find that within these species there are strains associated with inflammation and strains that are commensal, and beneficial. Gold Standard Certification Sequential has developed the gold standard test for products designed to target the microbiome, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. Using next-generation sequencing of the collection of micro-organisms found on the body, before and after product usage, Sequential investigates the microbial balance and diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. We give you an in vivo certification that your product maintains the microbiome. And it’s not exclusive to skincare! We do this for haircare products, oral products, and vulva/vaginal microbiomes. Personalize Your Microbiome Study! Supplement Your Microbiome Study Recruitment Services Let us take care of the entire candidate recruitment process for you! View More Biophysical Assessments Increase your data on the use of your product by evaluating additional biophysical factors. View More Formulation Support Seek consultation advice for your formulation if you are re-formulating or developing a new product. View More FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

How do I Rebuild my Skin Microbiome? How do I Rebuild my Skin Microbiome? Our skin, as we know to be the body's largest organ, hosts a plethora of microorganisms. An elaborate ecosystem of bacteria, fungi, and viruses that live on the skin and maintain its optimal health, making up the skin microbiome (Smythe & Wilkinson, 2023). These microorganisms serve as a protective barrier against harmful pathogens, aid in immune system regulation, and play a vital role in various skin functions. However, factors such as harsh skincare products, poor diet, and environmental stressors can disrupt the balance, leading to acne, eczema, and other skin disorders (Wallen-Russell, 2019). Restoring the skin microbiome involves a complex and multifaceted approach that includes lifestyle changes, targeted skincare practices, and sometimes dietary adjustments. Understanding the Skin Microbiome The microbiome varies depending on the region of the skin, with different areas hosting distinct microbial communities. Fournière et al. (2020) examine how Staphylococcus epidermidis and Cutibacterium acnes, key skin microbiota components, vary across different skin environments. For instance, Staphylococcus species are mainly in moist areas like axillary and popliteal creases, while Cutibacterium species are found in sebaceous areas such as the face and back. An ideal and healthy skin microbiome is diverse, and resilient, capable of adapting to changes and defending against adversaries. Steps to Restore the Skin Microbiome 1. Use Less & Gentle Skincare Products: Using lesser products would simplify one’s skincare routine, making it easier to stay consistent and therefore allow the skin to adjust and benefit from the active ingredients. Hwang et al. (2021) further suggests that in order to restore the skin microbiome, one should actively choose products with essential ingredients which are natural, soothing and non-disruptive to the skin's natural barrier. 2. Incorporate Probiotics, Prebiotics and Postbiotics: Just as the gut microbiome benefits from probiotics, so does the skin. Probiotic skincare adds beneficial bacteria to restore skin balance, while prebiotics nourish existing good bacteria to boost their growth. Common probiotics include Lactobacillus and Bifidobacteria, found in drinks, powders, tablets, and fermented dairy products (Gowda, et al. 2024). 3. Protect Your Skin from Environmental Stressors: Limit exposure to environmental pollutants and the sun, which can damage the skin barrier and disrupt the microbiome (Wang et al., 2021). Using protective measures like sunscreen, wearing protective clothing, and cleansing your skin regularly can help maintain the integrity of the skin barrier and support a balanced microbiome. 4. Moisturise Regularly: Keeping the skin well-hydrated is crucial for maintaining a healthy microbiome. Dry skin can compromise the skin barrier, making it easier for harmful bacteria to invade. Use a moisturiser that contains ingredients like ceramides, which help to strengthen the skin barrier, and hyaluronic acid to retain moisture. (Spada & Greive, 2018) 5. Pay Attention to Diet: A diet rich in fruits, vegetables, and whole grains supports skin microbiome health with essential vitamins, minerals, and antioxidants. Omega-3 fatty acids, found in fish and flaxseeds, are particularly beneficial as they have anti-inflammatory properties that can help maintain a balanced skin microbiome. (Costantini, Molinari & Merendino, 2017) Conclusion Restoring the skin microbiome is an ongoing process that demands consistent effort and dedication. By understanding the skin microbiome and incorporating strategies to support its health, you can significantly enhance your skin's ability to protect against environmental stressors and lower the risk of skin disorders. References Smythe, P., & Wilkinson, H. N. (2023). The skin microbiome: Current landscape and future opportunities. International Journal of Molecular Sciences, 24(4), 3950. https://doi.org/10.3390/ijms24043950 Wallen-Russell, C. (2019). The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biology, 17(1), 47. https://doi.org/10.1186/s12915-019-0660-6 Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020). Staphylococcus epidermidis and Cutibacterium acnes: Two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms, 8(11), 1752. https://doi.org/10.3390/microorganisms8111752 Hwang, B. K., Lee, S., Myoung, J., Hwang, S. J., Lim, J. M., Jeong, E. T., Park, S. G., & Youn, S. H. (2021). Effect of the skincare product on facial skin microbial structure and biophysical parameters: A pilot study. MicrobiologyOpen, 10(5), e1236. https://doi.org/10.1002/mbo3.1236 Gowda, V., Sarkar, R., Verma, D., & Das, A. (2024). Probiotics in Dermatology: An Evidence-based Approach. Indian dermatology online journal, 15(4), 571–583. https://doi.org/10.4103/idoj.idoj_614_23 Wang, L., Xu, Y. N., Chu, C. C., Jing, Z., Chen, Y., Zhang, J., Pu, M., Mi, T., Du, Y., Liang, Z., Doraiswamy, C., Zeng, T., Wu, J., & Chen, L. (2021). Facial Skin Microbiota-Mediated Host Response to Pollution Stress Revealed by Microbiome Networks of Individual. mSystems, 6(4), e0031921. https://doi.org/10.1128/mSystems.00319-21 Spada, F., Barnes, T. M., & Greive, K. A. (2018). Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, cosmetic and investigational dermatology, 11, 491–497. https://doi.org/10.2147/CCID.S177697 Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017). Impact of Omega-3 Fatty Acids on the Gut Microbiota. International journal of molecular sciences, 18(12), 2645. https://doi.org/10.3390/ijms18122645

Sequential is proud to announce that is has been dubbed the most significant testing method in the industry for microbiome testing. Allē Award: Sequential Wins Prestigious “Most Significant” Testing Method After being listed as a finalist as best ‘Claims testing methods & tools’ alongside Evonik, and XCellR8 - Sequential brings home top prize in C&T’s Allē Awards, 2022. The personal care and cosmetics industry in the US is valued at $190B. In the context of the skin microbiome, the industry is still a relatively nascent field. However, its projected growth is significant, estimated to grow at a compounded annual growth of 29.2% between 2022-2028. Owed to the impact of products on the skin microbiome, consumer awareness, and understanding that our microbiome is intimately linked to our health. Sequential is the B2B microbiome testing arm for Sequential Skin Ltd, which has developed the world’s first end-to-end platform for companies to evaluate their products on the microbiome in vivo. They specialize in skin, scalp and intimate area microbiome. "Of all the 'microbiome friendly' methodologies working to address both consumer and industry concerns about the impact of cosmetics on the microbiome, this is, in my opinion, the most quantitative and promising of the lot." – C&T's Allē Award judges, 2022. The company has developed a proprietary non-invasive method for collecting skin samples to analyze the skin microbiome using next-generation sequencing (NGS), with species and strain identification, in longitudinal (and clinical) studies. Services include data interpretation and the results are reported in a comprehensive, yet understandable format, ready for formulators and research scientists to incorporate into their product development pipeline. “The Allē Award gives us strong confidence in the testing platform and capabilities we’ve built in Sequential. Being the first to develop an in vivo microbiome test for the industry, we’re proud to see our hard work paying off” — Petronille Houdart, DPharm, skincare director at Sequential. About Sequential Sequential is part of the Sequential Skin group – with a US lab in New York City, alongside a lab in London and a lab in Singapore. Sequential team has over 20 years of combined expertise in genetics, epigenetics, and microbiome research. Sequential has validated its AI-driven testing platform with over 30 companies, analyzing over 12,000 skin microbiome samples. They specialise in skin, scalp and vulva/vaginal microbiome samples. They are supported by Enterprise SG, A*STAR, Genome Institute of Singapore, IndieBio New York, SOSV, Metaplanet Holdings, Scrum Ventures, Genedant VC, Ben Holmes (ex. General Partner at Index Ventures), Innovate UK, and are a resident company of Johnson & Johnson Innovation – JLABS.

Partner with a specialist CRO for microbiome, genomic, and biomarker analysis. Support complex studies with integrated, high-quality data. Extend your clinical capabilities with microbiome & multi-omics expertise SKIN | SCALP | INTIMATE | ORAL We partner with CROs to provide advanced microbiome, genomic, and biomarker analysis—supporting complex study requirements without compromising timelines, quality, or client expectations. Extend your study capabilities A specialist partner, integrated into your workflow Sequential acts as an embedded scientific partner, supporting CROs with advanced biological analysis while allowing you to retain full ownership of client relationships. We provide: Microbiome sequencing and analysis Multi-omics and genomic profiling Biomarker-driven study design Condition-specific expertise in dermatology Our team integrates seamlessly into your study workflow, ensuring: aligned protocols consistent data quality efficient communication across stakeholders When study complexity exceeds internal capabilities As clinical studies evolve, sponsors increasingly require: microbiome analysis genomic and epigenetic profiling biomarker-driven endpoints For many CROs, these capabilities are: not available in-house difficult to build quickly or inefficient to scale for specific studies This creates risk: delays in study delivery reliance on fragmented external vendors challenges maintaining quality and consistency Multi-omics expertise on demand Access advanced capabilities without the need to build internal infrastructure. Seamless integration into your workflows We operate as an extension of your team, aligning with your protocols, timelines, and client requirements. Quality reproducible data & results Validated assays, SOP-controlled processes, and in-house analysis ensure consistent, reliable outputs. A collaborative, CRO-aligned approach 1 Study Protocols Integration We align with your study design, endpoints, and client requirements to ensure seamless integration. 2 Sampling & Assay Execution We support non-invasive sampling and run validated microbiome and multi-omics assays under controlled conditions. 3 In-house analysis & interpretation All data is processed internally, ensuring quality, speed, and scientific consistency. 4 Reporting & delivery We deliver clear, structured outputs that integrate directly into your study reports and client deliverables. Results Sequential Patch Results Multi-Omics Results Packages

Sequential is honoured to be spoken and written about in numerous publications. We are always keen to speak about the great milestones we are hitting with our personal care microbiome testing platform. Sequential in the Press Men’s grooming shifts toward science-driven solutions 24-Feb-2026 Read Now Sequential: Testing shows skin microbiome plays a role in hyperpigmentation 7-Oct-2025 Read Now The bidirectional skin-gut microbiome: a game-changer for cosmetic formulators 29-Jul-2025 Read Now Sequential and AMILI Secure Prestigious $1.8M UK-Singapore Collaborative R&D Project 13-Feb-2025 Read Now Sequential Launches Industry-First Microbiome Target Panels for Skin Conditions 16-Oct-2024 Read Now From the experts: Top 3 trends in skin microbiome research 20-Jun-2024 Read Now Is Home-Based Skin Microbiome Testing Transforming Beauty and Health Care Industry? 7-Dec-2023 Read Now “Hormone-led changes cause differences to the vaginal ecology that can have an effect on women’s health later in life.” CEO of Sequential 13-Sep-2023 Read Now Sequential and Johnson & Johnson enter partnership to develop new genomic-based skin test 16-Mar-2023 Read Now Sequential Announces New Collaboration Agreement to Quantify Skin Health 15-Mar-2023 Read Now ‘Natural evolution’: Gallinée unveils at-home skin microbiome test kits with Sequential Skin 09-Mar-2023 Read Now Here They Are: Congratulations to the Winners of the 2022 C&T Allēs 29-Sep-2022 Read Now Sequential Skin: Why We Invested 11-Apr-2022 Read Now Sequential Skin Debuts Sequential Bio Testing Solution 09-Mar-2022 Read Now Biotech Start-Up Sequential Skin Raises Funds 10-Dec-2021 Read Now Biotech startup Sequential Skin raises €1.4m – ‘We want to accelerate the future of skin health,’ says CEO 11-Oct-2021 Read Now PODCAST – Holistic view on skin: Sequential Skin on why microbiome testing is crucial to personalised beauty 21-Aug-2020 Read Now Beauté personnalisée: Sequential Skin la Beauty Tech made in Singapore 07-Jul-2020 Read Now GWS 2019 DAY 2 Beauty, Science & Technology: Skin in the Game 25-Nov-2019 Read Now Science-led minimalism shapes future sustainable skin care 13-Jan-2026 Read Now Beautiful Bacteria: Are We On The Cusp Of Microbiome Mainstreaming? 28-Sep-2025 Read Now Sequential Skin and AMILI Secure $1.8M UK-Singapore Grant to Advance Gut-Skin Microbiome Science 14-Feb-2025 Read Now 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects Sep-2024 Read Now Is Microbiome Certification even Necessary? 29-Jul-2024 Read Now ‘It’s a really delicate system’: Research on vaginal microbiome shows how little we know about femcare 22-Jan-2024 Read Now Gallinée lance le premier test de santé de la peau et du microbiome à réaliser chez soi 10-Oct-2023 Read Now Lysine-dendrimer: a gentle yet effective acne treatment that maintains skin microbiome, says study 18-Aug-2023 Read Now Acne and ageing: J&J exploring skin health markers via Sequential Skin research tie-up 15-Mar-2023 Read Now Sequential Skin x Johnson & Johnson Collab to Quantify Skin Health 14-Mar-2023 Read Now Understand before purchase: Microbiome testing can help consumers find the right products and eliminate waste 30-Jan-2023 Read Now Sequential Wins New Grant To Propel Skin Microbiome Research 30-Jun-2022 Read Now Sequential Skin launches test to assess ingredient effect on microbiome 22-Mar-2022 Read Now Microbiome start-up Sequential Bio debuts first in-vivo testing for personal care industry 04-Mar-2022 Read Now Sequential Skin Raises $1.6M in Oversubscribed Seed Round 12-Oct-2021 Read Now The skin microbiome brainstorm: Tech, claims and trend-driven NPD 16-Sep-2021 Read Now Skin Sensors Enable Personalized Skin Care 20-Aug-2020 Read Now Sequential Skin: beauty tech’s new approach to genetic analysis and microbiome skincare 09-Mar-2020 Read Now How genetic insights can personalise skin microbiome launches 29-Jul-2019 Read Now Deep dive into Radiance Evaluation 9-Oct-2025 Read Now Men’s care shifts toward function-first to address skin needs beyond the basics 16-Sep-2025 Read Now Sequential and AMILI secure $1.8M UK-Singapore R&D project to advance gut-skin microbiome science 13-Feb-2025 Read Now New clinical testing to “investigate microbial roots of various skin conditions” 17-Oct-2024 Read Now Losing its meaning? ‘Microbiome-friendly’ terms at risk of misleading consumers – Sequential CEO 29-Jul-2024 Read Now Navigating the realm of intimate care products 17-Jan-2024 Read Now Avec ce test microbiome maison, 10 secondes m'ont suffit pour découvrir les besoins de ma peau 04-Oct-2023 Read Now Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin 3-Aug-2023 Read Now Sequential Announces New Collaboration Agreement to Measure Skin Health for Leading Developer of Personal Care Products 15-Mar-2023 Read Now Sequential Skin partners with Johnson & Johnson on microbiome tests 10-Mar-2023 Read Now Symbiome Partners with Skin Microbiome Testing experts at Sequential to Revolutionize Beauty Industry 26-Jan-2023 Read Now Sequential Skin Nabs $500K UK Grant to Study Skin Microbiome in Atopic Dermatitis 29-Jun-2022 Read Now Demands rising for clinical data on the skin microbiome: Experts 22-Mar-2022 Read Now ‘Maintaining the microbiome’: Biotech startup Sequential Skin debuts in vivo B2B testing service 03-Mar-2022 Read Now Start-up Sequential Skin bags $1.65m of fresh funding 12-Oct-2021 Read Now Singapore Beauty Startup Sequential Skin Uses Science to Help Identify the Best Skincare For You 07-Jan-2021 Read Now Overlooked opportunities? Skin microbiome may play a more important role in personalisation than DNA 13-Aug-2020 Read Now Sequential tool kit prioritises personalisation 15-Jan-2020 Read Now

< Back Marketing Associate Cambridge, UK Job Type Full-time Workspace Hybrid About the Role As a Marketing Associate at Sequential, you will play a critical role in shaping our brand, product (s) and ensuring our scientific expertise is communicated to the personal care and dermo-cosmetics industries. You will support the execution of marketing strategies that drive awareness, engagement and lead generation efforts to amplify Sequential’s footprint and contribute to commercial growth. Working closely with the Head of Marketing and cross-functional teams, you’ll help bring Sequential’s unique value proposition to life across digital channels, campaigns and tradeshows (+ conferences). This is an exciting opportunity for a creative, detail-oriented marketer to gain hands-on experience in a fast-growing biotech company at the forefront of microbiome and human biomarker testing innovation. An ideal candidate should have the drive to quickly learn our scientific offering to be able to translate them into strong marketable assets. We are looking for someone who will hit the ground running and be able to integrate into the team seamlessly. 3-6 months into the role, we expect a concrete understanding of our offerings, the ability to support in marketing efforts, and have ownership of individual duties and tasks to ensure smooth execution of overarching marketing strategies. Our end clients are B2B companies who operate in both personal care and pharma industries. Both these target groups require different marketing tactics to reach. In order to succeed within this role, a deep understanding of these industries, their pain points and objections will be critical. Essential Duties and Responsibilities: ●Marketing Campaign Support: Assist in the execution of marketing campaigns across digital, email, and content channels to support business and sales objectives. ●Content Development: Help create and coordinate marketing materials including website content, blog posts, email newsletters, social media content, presentations, and sales enablement assets. ●Brand and Messaging Alignment: Ensure all marketing materials are consistent with Sequential’s brand voice, positioning, and scientific credibility. ●Market and Customer Research: Support in conducting research on industry trends, customer needs, and competitor activity to inform marketing strategies and messaging. ●Digital Marketing & Analytics: Support website updates, email campaigns, and social media efforts; track performance metrics and assist in reporting insights. ●Support with Ads Strategies: Support with Google Ads and LinkedIn Ads to increase website traffic and lead generation form submissions. ●Cross-Functional Collaboration: Work closely with sales, product, and operations teams to ensure marketing initiatives align with commercial goals and customer needs. ●Product and Scientific Knowledge: Develop a strong understanding of Sequential’s offerings and the microbiome and human biomarker landscape to effectively communicate value to target audiences. Qualifications and Experience: ●1–2 years of experience in marketing, communications, or a related role; experience in biotechnology, life sciences, or cosmetics is preferred. ●Working knowledge of Canva for brand-aligned digital content creation is essential. ●Quick to learn scientific concepts as a large part of the role consists of taking complicated science and translating it into tangible benefits for the industry. ●Familiarity with digital marketing tools LinkedIn, Google Ads & Analytics, Hubspot, Wix & Meta Ads is preferred. ●Excellent written and verbal communication skills with an eye for detail and storytelling. ●Creative mindset paired with analytical thinking and comfortable thinking out of the box and owning small projects. ●Bachelor’s degree in Marketing & Communications (or equivalent) with a strong interest in the pharma, dermo-cosmetics, personal care industry. ●Highly organized self-starter with the ability to work on multiple projects in a fast-paced environment. ●Collaborative, adaptable, and eager to learn in a growing company. What You Get from Us: • A competitive base salary with opportunities for growth as the company scales. • Access to our Equity Incentive Plan, allowing you to grow alongside Sequential. • Hands-on experience working with industry experts in a rapidly expanding biotech sector. • The opportunity to help shape the brand of a company advancing microbiome science and its real-world applications. About the Company Sequential is an established global leader in clinical product testing for the personal care and dermo-cosmetics industries. Formed by a team of PhD experts in genetics, epigenetics, and microbiome research, the company specializes in microbiome and human biomarker testing to champion topical products’ impacts in real use cases across skin scalp, oral and vulvovaginal formulations. The company is an Innovate UK and Enterprise Singapore-backed company, with labs in Cambridge, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 50,000 human skin microbiome samples and corresponding formulations tested clinically. With this vast genomic dataset, Sequential is figuring out optimal formulations that could potentially alleviate skin conditions, such as for acne, atopic dermatitis and rosacea. The company has been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $5MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology. Apply Now

How Do I Test My Microbiome? How Do I Test My Microbiome? The microbiome refers to the collection of trillions of microorganisms, such as bacteria, fungi, and viruses, that live in and on your body, particularly in your gut. (Lloyd-Price, Abu-Ali & Huttenhower, 2016) These microbes are vital components in maintaining our health by aiding digestion, regulating the immune system, and even influencing mood and overall brain function. Given the growing interest in the microbiome's impact on overall well-being, testing the microbiome has broadened its appeal among people. Here's an overview of the process, why it's important, and what the results could reveal. Types of Microbiome Tests Skin tests: Skin microbiome samples are typically collected using non-invasive methods, such as swabs, tape strips, or skin scrapings. A swab is gently rubbed over the surface of the skin to capture microbial communities from different body areas, depending on the research or diagnostic needs. These samples are then sent to a lab for DNA sequencing to identify and quantify the microbial species present (Grice & Segre, 2011). This approach allows for a deeper understanding of how the skin's microbial balance impacts health conditions like acne, eczema, and skin infections. Saliva tests: Saliva microbiome testing is a non-invasive approach to assess the bacterial communities in the mouth, offering insights into oral and overall health. Through next-generation sequencing, saliva samples can reveal significant shifts in microbial composition, serving as early biomarkers for health conditions. For example, Aas et al. (2005) demonstrated that saliva microbiome testing could reveal distinct bacterial profiles associated with oral diseases, suggesting its importance in both oral and systemic health management. Stool tests: Stool microbiome testing evaluates the gut’s microbial composition by analysing bacteria, viruses, and fungi in stool samples. This non-invasive test helps identify microbial imbalances (dysbiosis) linked to conditions like irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders. By using next-generation sequencing, it reveals the diversity and abundance of gut microbes, which can inform insights into digestive, immune, and even mental health. Zhernakova et al. (2016) highlighted its potential in detecting gut-related health issues and promoting personalised healthcare strategies. Comprehensive clinical tests: In some cases, healthcare providers may recommend a more comprehensive testing that goes beyond the standard saliva and stool samples which include blood tests or even tissue biopsies; particularly when chronic conditions are present. These approaches can hold valuable information regarding systemic infections or localised imbalances in microbiota, which can significantly aid in the management of diseases such as inflammatory bowel disease and even cancer. (Schulfer & Blaser, 2015) Conclusion By testing our microbiome, we dive into important insights of our overall health by identifying imbalances in microbial communities, known as dysbiosis, which are interlinked to various health conditions. Understanding our microbiome composition allows for customised dietary and lifestyle adjustments to restore balance, as specific gut bacteria are essential for digestion, immune function, and mood regulation. (Zhernakova et al., 2016; Young, 2017) Advancements in microbiome research show that testing can aid in managing chronic diseases by guiding personalised treatment and dietary plans based on an individual's microbial profile, improving clinical outcomes and overall well-being (Lloyd-Price et al., 2016; Hu et al., 2021). Regular testing can optimise health, particularly concerning the gut-brain axis and metabolic health. References Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005). Defining the normal bacterial flora of the oral cavity. Journal of Clinical Microbiology, 43(11), 5721-5732. https://doi.org/10.1128/JCM.43.11.5721-5732.2005 Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(51), 1-11. https://doi.org/10.1186/s13073-016-0307-y Schulfer, A., & Blaser, M. J. (2015). Risks of antibiotic exposures early in life on the developing microbiome. PLoS Pathogens, 11(7), e1004903. https://doi.org/10.1371/journal.ppat.1004903 Zhernakova, A., et al. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369