The Future of Next-Generation Ingredients & Validation. A full day for senior R&D, innovation and scientific leaders across beauty, personal care and biotechnology, exploring multiomics, the skin microbiome, bioengineered actives and the evidence the market now demands. About the event Where ingredient innovation meets the evidence behind it Sequential is bringing together senior R&D, innovation and scientific leaders from across the beauty, personal care and biotechnology industries for an exclusive full-day event on the future of next-generation ingredient innovation and validation. Expect sharp, practical talks, a moderated roundtable and time to connect with peers. FORMAT: Talks · Panel · Roundtable AUDIENCE: Senior R&D & Innovation Leaders VENUE: Attenborough Room, The Mills Fabrica, London Voices From Across the Industry Lieve Declercq Proya Cosmetics Regenerative biotechnology, a biomimetic Collagen XVII platform, and the future of global R&D collaboration between China and Europe. Dr. Albert Dashi Sequential Chief Science Officer & Co-founder. Behind the science: how Sequential validates next-generation ingredient claims. John Milligan The Honey Pot Company Destigmatizing intimate health and formulating for the fast-growing women’s health category. Christina Patane Medik8 Longevity, the skin microbiome, and Medik8’s five-year innovation roadmap. Martin Pagac DSM-Firmenich 3D facial microbiome mapping and the emerging role of human milk oligosaccharides (HMOs) in skin health. Veronika Oudova S-Biomedic Building the live skin probiotic category, the founder’s journey from idea to market. Dr. Amir Jassim AI Specialist Formerly University of Cambridge & Cancer Research UK. A fast-paced look at where AI is accelerating discovery and validation. On the day Thursday 3 December, 9:00am – 4:30pm Attenborough Room, The Mills Fabrica, London. Timings may shift slightly as the programme is finalised. 9:00am Registration and coffee on arrival 10:15am Keynote - Lieve Declerca, Proya 10:45am - 1:00pm Speaker talks & coffee break 1:20pm Lunch 3:10pm Al in Ingredient Discovery - Dr. Amir Jassim 3:20pm Roundtable discussion - all speakers 4:05pm Networking 4:30pm Close

The Future of Next-Generation Ingredients & Validation. A full day for senior R&D, innovation and scientific leaders across beauty, personal care and biotechnology, exploring multiomics, the skin microbiome, bioengineered actives and the evidence the market now demands. About the event Where ingredient innovation meets the evidence behind it Sequential is bringing together senior R&D, innovation and scientific leaders from across the beauty, personal care and biotechnology industries for an exclusive full-day event on the future of next-generation ingredient innovation and validation. Expect sharp, practical talks, a moderated roundtable and time to connect with peers. FORMAT: Talks · Panel · Roundtable AUDIENCE: Senior R&D & Innovation Leaders VENUE: Attenborough Room, The Mills Fabrica, London Voices From Across the Industry Lieve Declercq Proya Cosmetics Regenerative biotechnology, a biomimetic Collagen XVII platform, and the future of global R&D collaboration between China and Europe. Dr. Albert Dashi Sequential Chief Science Officer & Co-founder. Behind the science: how Sequential validates next-generation ingredient claims. John Milligan The Honey Pot Company Destigmatizing intimate health and formulating for the fast-growing women’s health category. Christina Patane Medik8 Longevity, the skin microbiome, and Medik8’s five-year innovation roadmap. Martin Pagac DSM-Firmenich 3D facial microbiome mapping and the emerging role of human milk oligosaccharides (HMOs) in skin health. Veronika Oudova S-Biomedic Building the live skin probiotic category, the founder’s journey from idea to market. Dr. Amir Jassim AI Specialist Formerly University of Cambridge & Cancer Research UK. A fast-paced look at where AI is accelerating discovery and validation. On the day Thursday 3 December, 9:00am – 4:30pm Attenborough Room, The Mills Fabrica, London. Timings may shift slightly as the programme is finalised. 9:00am Registration and coffee on arrival 10:15am Keynote - Lieve Declerca, Proya 10:45am - 1:00pm Speaker talks & coffee break 1:20pm Lunch 3:10pm Al in Ingredient Discovery - Dr. Amir Jassim 3:20pm Roundtable discussion - all speakers 4:05pm Networking 4:30pm Close

The Future of Next-Generation Ingredients & Validation. A full day for senior R&D, innovation and scientific leaders across beauty, personal care and biotechnology, exploring multiomics, the skin microbiome, bioengineered actives and the evidence the market now demands. About the event Where ingredient innovation meets the evidence behind it Sequential is bringing together senior R&D, innovation and scientific leaders from across the beauty, personal care and biotechnology industries for an exclusive full-day event on the future of next-generation ingredient innovation and validation. Expect sharp, practical talks, a moderated roundtable and time to connect with peers. FORMAT: Talks · Panel · Roundtable AUDIENCE: Senior R&D & Innovation Leaders VENUE: Attenborough Room, The Mills Fabrica, London Voices From Across the Industry Lieve Declercq Proya Cosmetics Regenerative biotechnology, a biomimetic Collagen XVII platform, and the future of global R&D collaboration between China and Europe. Dr. Albert Dashi Sequential Chief Science Officer & Co-founder. Behind the science: how Sequential validates next-generation ingredient claims. John Milligan The Honey Pot Company Destigmatizing intimate health and formulating for the fast-growing women’s health category. Christina Patane Medik8 Longevity, the skin microbiome, and Medik8’s five-year innovation roadmap. Martin Pagac DSM-Firmenich 3D facial microbiome mapping and the emerging role of human milk oligosaccharides (HMOs) in skin health. Veronika Oudova S-Biomedic Building the live skin probiotic category, the founder’s journey from idea to market. Dr. Amir Jassim AI Specialist Formerly University of Cambridge & Cancer Research UK. A fast-paced look at where AI is accelerating discovery and validation. On the day Thursday 3 December, 9:00am – 4:30pm Attenborough Room, The Mills Fabrica, London. Timings may shift slightly as the programme is finalised. 9:00am Registration and coffee on arrival 10:15am Keynote - Lieve Declerca, Proya 10:45am - 1:00pm Speaker talks & coffee break 1:20pm Lunch 3:10pm Al in Ingredient Discovery - Dr. Amir Jassim 3:20pm Roundtable discussion - all speakers 4:05pm Networking 4:30pm Close

Specialist CRO trusted by 100+ brands to unlock the science behind personal care and therapeutics, with biomarker evidence for skin, scalp, oral and more. The Future of Next Generation Ingredients & Validation Expect sharp, insightful sessions focused on real innovation and go-to-market cases. Sign up to our event today. Dermocosmetics Pharma Therapeutics CRO Partnerships Ingredient Manufacturers Your End-to-End Clinical Research Partner Human clinical testing, biomarker discovery, and next-generation formulations powered by the world's most advanced multi-omics platform. 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Recruitment Database 100+ Industry Partners What We Offer From study design and participant recruitment to laboratory analysis and data interpretation, Sequential delivers an end-to-end, in-house solution for understanding how products interact in real use cases. Our clinically relevant insights translate complex microbial and molecular data into clear, actionable outcomes empowering companies to develop products that are credible, effective, and trusted by consumers. Start a study Supporting World-Class Clients & Partners Join Our Partners! What Our Clients Say “Sequential is one of the world’s most innovative Microbiome companies. The resolution at subspecies level, and to perform quantification of key vaginal microbes, in vivo , was exactly what we wanted at Curive Healthcare to know intricately how our product is working to improve women’s health.” - Matthew Line, Chief Marketing Officer at Curive Healthcare

Why leading personal care and pharma teams choose Sequential. Meet the award-winning scientists behind our end-to-end clinical research and multi-omics. We are a Team of Award-Winning Scientists Creating a World of Healthier Individuals Our platform is the result of our team’s combined expertise in genetics, epigenetics, and microbiome research. We utilise deep molecular analysis and next-generation sequencing (NGS) technology to understand the impact of product usage on an individual’s microbiome. Through our efforts, we hope to revolutionise the way in which the industry develops and tests its products to deliver optimal results to those utilising them. Our Mission Sequential is the industry leader in clinical human research and testing offering a comprehensive end-to-end platform designed to bring science-backed solutions to the personal care and pharmaceutical industry. Our mission is to understand the impact of the microbiome on the host (humans) and how the host impacts the microbiome in order to characterise human health fully. We offer an extensive platform to conduct research on personal care products through microbiome testing, and biophysical assessments, and offer full recruitment services for studies. We are keen to publish our findings with our partners to increase the literature within this space. At present our database of over 20,000 human microbiome samples is one of the most sophisticated within the industry and is growing rapidly. Innovation Pioneering the forefront of biological science, we consistently introduce groundbreaking advancements to redefine industry standards. Transparency Our commitment to openness ensures a clear understanding of our human microbiome testing processes and analysis. Reliability We guarantee dependable results, fostering trust in the accuracy of our analyses. Our Team at Sequential Oliver Worsley, PhD CHIEF EXECUTIVE OFFICER & CO-FOUNDER Albert Dashi, PhD CHIEF SCIENCE OFFICER & CO-FOUNDER Pétronille Houdart, PharmD SKINCARE DIRECTOR The Commercial Team Derek Butler, PhD MBA COMMERCIAL DIRECTOR Carla Brown, PhD, MBA SALES ASSOCIATE Marya Ahmed, MSc HEAD OF MARKETING Athena Hajaig, BSc MARKETING ASSOCIATE The Scientific Team Sibora Peca, MSc CLINICAL OPERATIONS LEAD Omera Bi, PhD, AFHE R&D PROJECT SPECIALIST Paola Lasluisa, MSc LABORATORY TECHNICIAN Grace Robinson, MSc ASSOCIATE SCIENTIST Khanh Lê Đào, BA JUNIOR CLINICAL ASSISTANT Behafarid Ghalandari, PhD SENIOR AI SCIENTIST Omololu Fagunwa, PhD SENIOR BIOINFORMATICIAN Sanjana Joshi, MSci JUNIOR CLINICAL ASSISTANT Amir Jassim, PhD SENIOR COMPUTATIONAL BIOLOGIST Sija Sajibu, PhD SENIOR SCIENTIST Ami Picari CLINICAL ASSISTANT Please find listed a selection of relevant peer-reviewed publications from our advisors. Wu G, TL Dawson, et al. (2015) Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. PLOS Genetics 11(11): e1005614. Chng, K., Nagarajan, N., et al. (2016) Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nat Microbiol 1, 16106. Tay, A.S., Nagarajan, N., et al (2018). 1039 Skin microbiome profiles of atopic dermatitis patients segregate into two community composition types that are stable before and after therapy. Journal of Investigative Dermatology. 138. S176. 10.1016/j.jid.2018.03.1051. Ramasamy S., Barnard, E., Dawson, TL, and Huiying Li. (2019). Role of the skin microbiota in acne pathophysiology. British Journal of Dermatology, https://doi.org/10.1111/bjd.18230. Dawson, TL. (2019) Malassezia: The Forbidden Kingdom Opens. Cell Host Microbe https://doi.org/10.1016/j.chom.2019.02.010 Tay, A.S., Nagarajan, N., et al (2020). Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity. The Journal of allergy and clinical immunology. 10.1016/j.jaci.2020.09.031. Dawson, TL. (2021) Malassezia: A Skin Commensal Yeast Impacting Both Health and Disease. Front. Cell. Infect. Microbiol., doi.org/10.3389/fcimb.2021.659219 Bissonnette, Robert & FAAD, & Palijan, Ana & Salem, Youssef & Maari, Catherine & Proulx, Etienne & Edjekouane, Lydia & Joly-Chevrier, Maxine & Devis, Andrew & Dashi, Albert & Worsley, Oliver. (2024). 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects. Journal of the American Academy of Dermatology. 91. AB224. 10.1016/j.jaad.2024.07.889. Supported By: Scientific Board of Advisors Our advisors are world leaders in the skin microbiome and have extensive experience in bringing forward solutions for skin concerns Prof. Tom Dawson Senior Principal Investigator at Skin Research Institute of Singapore. Over 30 years experience in biotechnology innovations, and expert in the skin and hair microbiome. Doctor of Philosophy (PhD), Pharmacology at the Univer sity of North Carolina. Dr Kimberly Capone Dr Kimberly Capone is a pioneer and established expert in microbiology and the human microbiome field where she created new business opportunities across multiple brands over 13 years at Johnson & Johnson Consumer, Inc. Areas of concentration included infant and adult skin, vaginal, gut, and oral health. Prof. Phillip Bennett Phillip Bennett is Professor of Obstetrics and Gynaecology and Director of the Institute of Reproductive and Developmental Biology. Professor Bennett has been one of the key pioneers in researching the vaginal microbiome. In particular, to understand and characterise the impact of the vaginal microbiome on preterm labour. Bennett has published over 400 peer-reviewed research articles over his career. Dr Natalya Fox Dr Natalya Fox is a Dermatologist at the NHS - St George's Hospital, London. Previously, Fox did her MBChB at the University of Edinburgh 201 4 and has her Full MRCP UK in Dermatology. Fox is passionate about the skin microbiome and its place in dermatology. Prof. Elena Lurie-Luke A senior R&D, Innovation and Entrepreneurship Executive with extensive technical, strategic business development. Proven leadership experience in both global FMCG and public health sector environments. Prof. Niranjan Nagarajan Associate Director & Senior Group Leader at Genome Institute of Singapore. Expert in computation biology, in particular the study of microbial communities resident on the human skin. Doctor of Philosophy (PhD), Computer Science at Cornell University. Dr Alexander Lezhava Senior Group Leader & Associate Director at Genome Institute of Singapore. Expert in the commercial development of medical diagnostics and clinical-grade molecular assays. Doctor of Philosophy (PhD), Microbiology at Hiroshima University. Supporting Global Studies Our Labs Sequential has clinical testing labs in New York City, Cambridge, and Singapore. Being close to our customers has allowed us to reduce turnaround time while retaining intellectual property in-house. Cambridge Lab Moneta Building Babraham Research Campus, Cambridge CB22 3AT New York Lab Sequential (SOSV) 7 Penn Plaza, 9th Fl, New York NY 10001 Singapore Lab Astar Central 79 Ayer Rajah Crescent, Singapore 139955 Supporting World-Class Clients & Partners

See what's currently underway at Sequential. Active human clinical studies across skin, scalp, oral care and skin health supplements. Ongoing Studies US Lab Studies UK Lab Studies Singapore Lab Studies US Lab Studies Status: In Progress Topical Moisturiser Study (Sensitive Skin) Randomised, evaluator-blinded, exploratory trial comparing a moisturiser vs. occlusive control on contralateral volar forearms; TEWL, corneometry, pH, questionnaire and microbiome/inflammatory panel at screening, baseline and day 28. Number of Participants: 24 targeted for recruitment Recruitment Criteria: Adults 18–55, self-declared sensitive skin, mixed Fitzpatrick types, screening TEWL >15 g/m²/h, 7-day product washout required Status: In Progress Vaginal Microbiome Study (Intimate Wipe) Studies an intimate wipe product's effect on vulvar/vaginal microbiome and pH; swabs at baseline (cycle day 5–7) and day 30. Number of Participants: 35 recruited; 30 samples analysed Recruitment Criteria: Healthy participants Status: In Progress Acne Microbiome Study (Topical Antibacterial) Active-vs-placebo study of a topical antibacterial product; patch collection at day 0 and week 12 (may shift to day 28). Number of Participants: 30 analysed (15 product / 15 placebo) Recruitment Criteria: Participants with acne lesions Status: In Progress Oral Probiotic Study (Multiple Indications) Double-Blinded, Placebo-Controlled, Longitudinal Study. Skin (Facial); Oral supplement impact on skin health and cosmetic improvements; Blood and patch/swab samples taken for omics and biomarker assessments. Number of Participants: 140 Recruitment Criteria: Multi-centre meta-analysis Status: In Progress Intimate Care Product Microbiome Meta-Analysis Secondary meta-analysis of existing microbiome data from prior intimate-care product studies, rather than a new primary study with its own recruited cohort. Number or Participants: 300+ Recruitment Criteria: Multi-centre meta-analysis Status: In Progress Vulvar Odor Product Study (Gel Wash & Wipes) Randomized, open-label, crossover study of an odor-control gel wash and wipes on the vulvar area; swabs at baseline, week 1 and week 2 for each product, assessing malodor, pH and targeted metabolomics. Number or Participants: 45 recruited; target 40 completers Recruitment Criteria: Healthy participants Status: In Progress Hair & Scalp Microbiome Study (Oral Supplement) Longitudinal, open-label, single-arm multi-omics study evaluating a daily oral hair/scalp supplement's effect on scalp microbiome and gene expression; scalp samples collected at baseline, week 4 and week 8. Number or Participants: 65 (15-participant subset for gene expression analysis) Recruitment Criteria: Healthy participant Status: In Progress Body Wash Skin Study (Onsite) Randomised controlled trial of a body wash on volar forearm skin; microbiome (patch) and biophysical measures (pH, TEWL, Corneometer) over 7 days; lipidomic samples collected but stored for future analysis only. Number of Participants: 35 (15 active / 15 vehicle control) Recruitment Criteria: Mixed men and women, aged 18–65, normal skin type, at least one participant per Fitzpatrick type I–VI Status: In Progress Topical Active Ingredient Study (Eczema-Prone Skin) Single-site, randomised, double-blind, placebo-controlled study of a topical active ingredient (two concentrations) on eczema-affected skin; swabs and biophysical metadata at baseline and week 2. Number of Participants: 36 (two active concentrations plus placebo) Recruitment Criteria: Female and/or male, aged 18–75, mild-to-moderate eczema (excluding feet and face), all races/ethnicities Status: In Progress Acne Skincare Regimen Study (On-site) On-site clinical study of a multi-step skincare regimen (cleanser, moisturizer, exfoliant); dermatologist grading, imaging, microbiome swabs and biophysical measures at day 0, 14 and 30. Number of Participants: 25 Recruitment Criteria: Moderate acne (5+ active lesions), male and female, ethnically diverse Status: In Progress Vulvar & Vaginal Malodor Study (Menstrual Care Product) Randomised controlled trial of a menstrual care product (active vs placebo); vulvar and vaginal microbiome/metabolites assessed via 16S sequencing at baseline, day 7 and day 14. Number of Participants: 40 Recruitment Criteria: Females aged 18+ Status: In Progress Facial Moisturiser Study Single-arm clinical trial of a facial moisturiser; skin patch samples collected at baseline, week 1 and week 4. Number or Participants: 35 Recruitment Criteria: Healthy participants with oily/combination facial skin Status: In Progress Axillary Malodor Study (Deodorant) Assesses a deodorant product's effect on the axillary (underarm) microbiome linked to malodor; underarm swabs at baseline and 48 hours post-application, analyzed with a targeted qPCR malodor panel. Number or Participants: 44 Recruitment Criteria: Healthy participants undergoing deodorant efficacy testing UK Lab Studies Status: In Progress Post-Procedure Skin Microbiome Study (Scar Sites) Longitudinal, placebo-controlled study of skin microbiome changes at recent minor-procedure (mole-removal) sites; swabs at Day 0 and Day 28. Number of Participants: 50 recruited; 30 selected for sequencing analysis (15 product / 15 placebo) Recruitment Criteria: Subjects who have recently undergone a minor skin procedure (mole removal) Status: In Progress Oral Probiotic & Skin Health Clinical Trial Double-blinded, placebo-controlled, longitudinal in-person trial of an oral probiotic's effect on facial skin health (wrinkles, TEWL, elasticity, moisture) via imaging, biophysical measures and omics sampling over 12 weeks. Number of Participants: 128 completers targeted; 140 recruited (2 arms, 64 per arm) Recruitment Criteria: Healthy women, dry to very dry skin, aged 35–45 Status: In Progress Recurrent UTI Probiotic Clinical Trial Remote randomised controlled trial (blinded, placebo- and active-controlled) of a probiotic for recurrent UTI prevention; vaginal, urine and stool sampling at baseline, 3 and 12 months (plus urine at each UTI episode). Number of Participants: 100 target completers (110 enrolled, allowing for dropout) Recruitment Criteria: History of recurrent UTIs (3+ in 12 months), diagnosed by a doctor and prescribed antibiotics Status: In Progress Axillary (Underarm) Skin Study (Split-Body Design) Placebo-controlled, split-body (split-armpit) study of microbiome/metabolite changes after product use; untargeted metabolomics and qPCR skin panel. Number of Participants: 30 recruited; analysis performed on 25 participants Recruitment Criteria: Healthy volunteers; recruited externally by the study sponsor Singapore Lab Studies Status: In Progress Facial Skin Metatranscriptomics Study (Exploratory) Controlled, within-subject crossover pilot study of product-driven change in facial skin microbiome function via metatranscriptomics across two products. Number of Participants: 12 adults Recruitment Criteria: Healthy adults pre-selected for high bacterial load per sponsor's pre-screening criteria Status: In Progress Eczema Cream Microbiome Study (Metatranscriptomics) Randomised, double-blind, placebo-controlled, longitudinal study of an eczema cream; skin microbiome swabs (metatranscriptomics) from the forearm (and possibly other areas) at baseline and day 28. Number of Participants: 20 (10 active / 10 vehicle control) Recruitment Criteria: Atopic dermatitis/eczema-prone skin, mild-to-moderate severity; sampling limited to the treated lesion area What do I do next? Planning a clinical study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and measurements. Design Your Study

The right participants for your clinical study. We recruit and screen cohorts by phenotype, behaviour and health status, not demographics alone. The Right Participants for Your Research Recruit study populations matched to your protocol, product and research objectives. From healthy participants and targeted consumer profiles to specific skin, scalp, oral and intimate health characteristics, Sequential builds human cohorts around the questions you need to answer. Discuss your recruitment needs Recruitment Built for Human Research 10,000 Participants in our network 100+ Recruited studies 6mos. + Age range 3 Recruitment labs Who can you recruit Find the Population Your Study Needs Go beyond broad demographics. Sequential recruits and screens participants against study-specific inclusion and exclusion criteria, helping you build cohorts defined by phenotype, condition, behaviour, demographics and other relevant characteristics. Targeted Populations Study-specific characteristics and defined populations aligned with your protocol and research objectives. Go Beyond Demographics The right study population isn't defined by age and sex alone. Sequential can combine demographic, phenotypic, behavioural and health characteristics to identify participants aligned with your biological and clinical research questions. How recruitment works From Protocol to Participant We translate your study objectives into practical recruitment criteria, identify suitable participants and manage screening through enrolment, helping build the right cohort before your study begins. 01 Define Translate your protocol and research objectives into participant criteria. 02 Identify Match potential participants against demographic, phenotypic, behavioural and health characteristics. 03 Screen Pre-screen against study-specific inclusion and exclusion criteria. 04 Enrol Confirm eligible participants and coordinate enrollment into your study. 05 Retain Support participants throughout the study to help maintain engagement and protocol compliance. Personal care and pharma Recruitment Across Consumer & Therapeutic Research Recruitment Across Consumer & Therapeutic Research Recruit targeted consumer populations for skincare, scalp care, oral care, intimate care and supplement studies, from product efficacy and claims research to exploratory biomarker studies. Pharma & Therapeutics Recruit study populations around defined clinical and biological characteristics for dermatology and other therapeutic research, aligned with protocol-specific eligibility criteria. SKIN SCALP ORAL INTIMATE SUPPLEMENTS Next steps Planning a study or want to join one? For Brands and Researchers For Participants Run a study with us Take part in research Send us your eligibility criteria and we will come back on feasibility, timelines and cost. See what studies we're recruiting for now or register your interest and we'll be in touch. Design Your Study Join a Study Check out our ongoing studies Ongoing studies Supporting Global Studies Our Labs Sequential has clinical testing labs in New York City, Cambridge, and Singapore. Being close to our customers has allowed us to reduce turnaround time while retaining intellectual property in-house. Cambridge Lab Moneta Building Babraham Research Campus, Cambridge CB22 3AT New York Lab Sequential (SOSV) 7 Penn Plaza, 9th Fl, New York NY 10001 Singapore Lab Astar Central 79 Ayer Rajah Crescent, Singapore 139955

Investigate how supplements and ingestible products affect skin, scalp, and intimate biology, with human and microbiome biomarkers. Clinical Testing Supplements Generate robust human evidence for beauty supplements, nutraceuticals and ingestible personal care. From efficacy to mechanisms of action, Sequential helps you understand how your formulation affects human health from within. Design your study Compare methods Probiotics Prebiotics Capsules Powders Gummies Drinks Validate your supplement formulations Analysis For All Your Ingestibles Sequential provides cutting-edge testing designed to work with all supplements designed for inside-out benefits. We take into account the gut-skin axis to help you discover that your product's desired outcomes are backed by clinical data. Design your study What can we help you prove Build Evidence Around The Questions That Matter Clinical Efficacy Demonstrate measurable product performance. Novel Claims Generate evidence to support differentiated claims. Mechanism of Action Understand how and why your formulation works. Product Differentiation Compare formulations, ingredients or concentrations. What can we measure Go Beyond Traditional Clinical Endpoints Build a deeper picture of supplement response by combining molecular, microbial and biophysical data. Connect systemic biological changes with measurable outcomes and explore mechanisms that traditional endpoints alone may not reveal. Human Biomarkers Measure molecular responses and investigate biological pathways associated with your supplement or ingredient. Find out more Read More Study design Built Around Your Research Question From exploratory biomarker studies to efficacy-focused clinical research, we tailor study design, recruitment, sampling and analysis to your supplement, population and objectives. Design Recruit Collect Analyse Interpret Why Leading Brands Choose Sequential 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Participant Database What do I do next? Planning a Supplements Study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and measurements. Design Your Study Dive Deeper Into Supplements Check out our collection of scientific papers, peer-reviewed research, and in-depth clinical articles. Inside-out Skincare Jan 29 2 min read Female reproductive tract - Gut axis: everything is connected Oct 2, 2025 3 min read The potential of probiotics in oral microbiome health Sep 24, 2025 2 min read 1 2 3

Test toothpastes, mouthwashes, gels, lozenges and oral treatments in vivo. Oral health studies with human and microbiome biomarkers and biophysical data. Clinical Testing for Oral Care Formulations Generate robust human evidence for oral care products and therapeutic formulations. From efficacy to mechanisms of action, Sequential helps you understand how your formulation affects oral health in real people. Design your study Compare methods Toothpaste Mouthwash Oral Gel Whitening Gel Oral Spray Moisturiser Targeted Treatments Validate your oral care formulations From Everyday Oral Care to Targeted Treatments Sequential provides cutting-edge in vivo multiomics testing for moisturizers, serums, cleansers, SPF formulations, and beyond. We analyze the complex relationship between the host skin and the microbiome using real people from our global database. Design your study What can we help you prove Build Evidence Around The Questions That Matter Clinical Efficacy Demonstrate measurable product performance. Novel Claims Generate evidence to support differentiated claims. Mechanism of Action Understand how and why your formulation works. Product Differentiation Compare formulations, ingredients or concentrations. What can we measure Go Beyond Traditional Clinical Endpoints Build a deeper picture of oral health by combining molecular, microbial and clinical data. Explore biological response, microbial ecology and mechanisms that traditional endpoints alone may not reveal. Human Biomarkers Measure molecular responses and investigate biological pathways relevant to oral health and your formulation. Find out more Read More Study design Built Around Your Research Question From exploratory microbiome and biomarker studies to efficacy-focused clinical research, we tailor study design, recruitment, sampling and analysis to your formulation, population and objectives. Design Recruit Collect Analyse Interpret Why Leading Brands Choose Sequential 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Participant Database What do I do next? Planning an Oral Care Study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and measurements. Design Your Study Dive Deeper Into Oral Care Check out our collection of scientific papers, peer-reviewed research, and in-depth clinical articles. The Effects of Teeth Whitening on the Oral Microbiome Oct 14, 2025 2 min read The potential of probiotics in oral microbiome health Sep 24, 2025 2 min read It’s All Connected: What Does the Oral-Gut Microbiome Axis Mean for Overall Health? Jun 4, 2025 2 min read 1 2 3 4 5

Generate robust clinical evidence for scalp care formulations, actives and treatments. We test shampoos, conditioners, serums, oils and topical therapies. Clinical Testing for Scalp Care Formulations Generate robust human evidence for scalp care products and therapeutic formulations. From efficacy to mechanisms of action, Sequential helps you understand how your formulation affects the scalp in real people. Design your study Compare methods Shampoo Conditioner Masks Serums Leave-ins Treatments Validate your scalp care formulations Everyday Scalp Care to Targeted Treatments Sequential provides cutting-edge testing designed to work with all types of products and formulations. We take into account the desired outcome of your product to ensure that all critical questions around efficacy and impact are measured with clinical data. Design your study What can we help you prove Build Evidence Around The Questions That Matter Clinical Efficacy Demonstrate measurable product performance. Novel Claims Generate evidence to support differentiated claims. Mechanism of Action Understand how and why your formulation works. Product Differentiation Compare formulations, ingredients or concentrations. What can we measure Go Beyond Traditional Clinical Endpoints Build a deeper picture of scalp response by combining molecular, microbial and biophysical data. Explore efficacy, biological pathways and mechanisms that traditional endpoints alone may not reveal. Human Biomarkers Measure molecular responses and investigate biological pathways associated with scalp health and your formulation. Find out more Read More Study design Built Around Your Research Question From exploratory biomarker studies to efficacy-focused clinical research, we tailor study design, recruitment, sampling and analysis to your formulation, population and objectives. Design Recruit Collect Analyse Interpret Why Leading Brands Choose Sequential 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Participant Database What do I do next? Planning a Scalp Care Study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and measurements. Design Your Study Dive Deeper Into Scalp Care Check out our collection of scientific papers, peer-reviewed research, and in-depth clinical articles. Skincare for the Scalp: Is Treating the Scalp Microbiome the Solution to Greasy Hair? Oct 7, 2025 2 min read The Future of Folliculitis Decalvans: What are the Scalp Microbiome Implications? Apr 23, 2025 2 min read Uncovering the Role of the Scalp Microbiome in Psoriasis: A Path to Better Treatment Mar 20, 2025 2 min read 1 2 3 4 5

Evaluate intimate care products and treatments and their effect on the vulvovaginal environment, with human and microbiome biomarkers. Clinical Testing for Intimate Care Formulations Generate robust human evidence for intimate care products and therapeutic formulations. From efficacy to mechanisms of action, Sequential helps you understand how your formulation affects intimate health in real people. Design your study Compare methods Cleansers Gels Lubricants Wipes Menstrual Barrier Cream Moisturising Cream Validate Your Intimate Care Formulations From Everyday Intimate Care to Targeted Treatments Sequential provides cutting-edge testing designed to work with all types of intimate product lines and formulations. We take into account your product's desired outcome to ensure that all critical questions about efficacy and impact are measured using clinical data. Design your study What can we help you prove Build Evidence Around The Questions That Matter Clinical Efficacy Demonstrate measurable product performance. Novel Claims Generate evidence to support differentiated claims. Mechanism of Action Understand how and why your formulation works. Product Differentiation Compare formulations, ingredients or concentrations. What can we measure Go Beyond Traditional Clinical Endpoints Build a deeper picture of intimate health by combining molecular, microbial and clinical data. Explore biological response, microbial ecology and mechanisms that traditional endpoints alone may not reveal. Human Biomarkers Measure molecular responses and investigate biological pathways relevant to intimate health and your formulation. Find out more Read More Study design Built Around Your Research Question From exploratory microbiome and biomarker studies to efficacy-focused clinical research, we tailor study design, recruitment, sampling and analysis to your intimate care formulation, population and objectives. Design Recruit Collect Analyse Interpret Why Leading Brands Choose Sequential 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Participant Database What do I do next? Planning an Intimate Care Study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and measurements. Design Your Study Dive Deeper Into Intimate Care Check out our collection of scientific papers, peer-reviewed research, and in-depth clinical articles. Beyond pH Feb 10 2 min read Female reproductive tract - Gut axis: everything is connected Oct 2, 2025 3 min read The Vaginal Microbiome: Unlocking Its Role in Post-Surgical UTI Prevention Jun 17, 2025 2 min read 1 2 3 4 5

Generate robust clinical evidence for skincare formulations, actives and topical treatments. We test serums, moisturisers, cleansers, SPF and creams. Clinical Testing for Skin Formulations Generate robust human evidence for skincare products and dermatological therapeutics. Sequential combines human biomarkers, skin microbiome analysis and biophysical assessments to measure efficacy and biological response in real people. Design your study Compare methods Moisturisers Serums Cleansers Masks SPF Toners Targeted Treatments Validate Your Skincare Formulations Everyday Skincare to Targeted Treatments Sequential provides cutting-edge testing designed to work with all types of products and formulations. We take into account the desired outcome of your product to ensure that all critical questions around efficacy and impact are measured with clinical data. Design your study What can we help you prove Build Evidence Around The Questions That Matter Clinical Efficacy Demonstrate measurable product performance. Novel Claims Generate evidence to support differentiated claims. Mechanism of Action Understand how and why your formulation works. Product Differentiation Compare formulations, ingredients or concentrations. What can we measure Go Beyond Traditional Clinical Endpoints Build a deeper picture of skin response by combining molecular, microbial and biophysical data. Explore efficacy, biological pathways and mechanisms that traditional endpoints alone may not reveal. Human Biomarkers Measure molecular responses and investigate biological pathways associated with your formulation. Find out more Read More Study design Built Around Your Research Question From early exploratory studies to efficacy-focused clinical research, we tailor study design, recruitment, sampling and analysis to your formulation, population and objectives. Design Recruit Collect Analyse Interpret Why Leading Brands Choose Sequential 50,000+ Sample Database 4,000+ Ingredients Database 10,000+ Participant Database What do I do next? Planning a Skincare Study? Tell us about your product and what you're looking to prove. We'll help you identify the right study design and target endpoints. Design Your Study Dive Deeper Into Skincare Check out our collection of scientific papers, peer-reviewed research, and in-depth clinical articles. Proteomics: The Hidden Layer of Skincare You Never See Feb 20 2 min read The Hidden Stress Of City Skin Feb 3 2 min read Inside-out Skincare Jan 29 2 min read 1 2 3 4 5