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Sequential provides advanced microbiome testing for personal care products, delivering actionable insights to enhance product efficacy and consumer trust. Your Clinical Research Partner End-to-end clinical research for skin, scalp, intimate & oral Human clinical testing, biomarker discovery, and next-generation formulations — powered by the world's most advanced multi-omics platform. 100+ 50,000+ 4,000+ 10,000+ Sample Database Ingredients Database Study Participants Industry Partners Dermocosmetics Pharma Therapeutics CRO Partnerships Ingredient Manufacturers What We Offer From study design and participant recruitment to laboratory analysis and data interpretation, Sequential delivers an end-to-end, in-house solution for understanding how products interact in real use cases. Our clinically relevant insights translate complex microbial and molecular data into clear, actionable outcomes empowering companies to develop products that are credible, effective, and trusted by consumers. Start a study See how it works Supporting World-Class Clients & Partners Join Our Partners! What Our Clients Say “Sequential is one of the world’s most innovative Microbiome companies. The resolution at subspecies level, and to perform quantification of key vaginal microbes, in vivo , was exactly what we wanted at Curive Healthcare to know intricately how our product is working to improve women’s health.” - Matthew Line, Chief Marketing Officer at Curive Healthcare

Who We Help Your end-to-end clinical testing partner. Dermocosmetics & Personal Care We help innovative dermocosmetic and personal care brands generate clinical-grade evidence and multi-omics insight, revealing not just efficacy, but true mechanisms of action and competitive positioning. Find out more Derm Pharma Therapeutics As a specialised CRO for dermatological therapeutics, we go beyond traditional study execution, delivering biomarker-driven clinical evaluation through validated assays, condition-specific expertise, and rigorous, reproducible methodologies. Find out more Clinical Research Organisations We partner with CROs to provide advanced microbiome, genomic, and biomarker analysis—supporting complex study requirements without compromising timelines, quality, or client expectations. Find out more Ingredient Manufacturers We help ingredient manufacturers generate robust, clinically relevant evidence by testing actives within controlled formulations, delivering clear insight into biological impact and optimal performance. Find out more Clinical Research Organisations We partner with CROs to provide advanced microbiome, genomic, and biomarker analysis—supporting complex study requirements without compromising timelines, quality, or client expectations. Find out more

Full End-To-End Testing Platform From study design and participant recruitment to laboratory analysis and data interpretation, Sequential delivers an end-to-end, in-house solution for understanding how products interact in real use cases. Our clinically relevant insights translate complex microbial and molecular data into clear, actionable outcomes empowering companies to develop products that are credible, effective, and trusted by consumers. Consultation & Study Design We collaborate with each client to create customised study protocols that align with specific objectives and ensure scientific precision. Clinically Validated Collection Our non-invasive collection system delivers consistent, high-quality samples and enables remote testing when needed. In-house Analysis & Reporting All analysis is performed in-house, ensuring speed, consistency, and direct access to our scientific and formulation experts. Candidate Recruitment Human participants are carefully selected by age, location, and other criteria to ensure relevant, accurate results. Multi-Omics Detection We combine microbiome sequencing, multi-omics technologies, and biophysical assessments to deliver a complete picture of skin health and product impact. Clinically Backed Results Our scientifically grounded reports transform complex data into claim-ready insights, empowering confident communication.

Discover the power of combining microbiome testing and clinical data. Elevate your understanding with our comprehensive Clinical Assessments. Clinical Assessments for More In-Depth Analysis When it comes to testing your personal care products, we offer add-ons to supplement your microbiome research efforts and facilitate your testing experience. It has become clear in recent years that differentiation is key when creating a formulation for the competitive market, however, differentiation can be incredibly straightforward when backed with the data and scientific evidence to support it. Not only will you differentiate your brand, you will also demonstrate your commitment to providing leading-edge and effective solutions for your customers’ personal care and skincare needs. Start Your Biophysical Study Today! The only way to understand how a product performs is by putting it to the test Hydration Measurement (Corneometry and TEWL) Gain a comprehensive understanding of your product's impact on moisture retention, skin hydration and overall skin barrier function. This data can guide the development of effective moisturizing formulations. Perception Questionnaire Uncovering how users experience and interact with products. These surveys offer valuable insights into subjective factors like texture, scent, and overall satisfaction ensuring that your scientific data is enriched. Elasticity Measurement (Elastometer) Unravel the effect your product has on the skin’s elasticity through the use of elastometers, allowing you to position your product within a firming category with demonstrated benefits for graceful aging. High-Resolution Imaging Use before and after images to provide visual evidence of a product’s impact on the skin’s appearance. These tangible comparisons offer brands the ability to objectively assess changes in the skin. Dermatologist Assessment Measure and quantify inflammatory disease, atopic dermatitis (through SCORAD), psoriasis (through PASI), comedogenicity, and other hallmarks of skin conditions, by our board-certified and in-house dermatologists. Skin pH Measurement Maintain the delicate balance of the skin's acid mantle with your product by measuring pH to ensure compatibility and minimise the risk of irritation for a gentle, biome supporting formulation. FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Test active ingredients in real-world formulations. Generate clinical evidence, assess dose-response, and support claim development. Prove the efficacy of your active ingredient on real skin CLINICAL TESTING DESIGNED TO VALIDATE PERFORMANCE We help ingredient manufacturers generate robust, clinically relevant evidence by testing actives within controlled formulations, delivering clear insight into biological impact and optimal performance. Design a validation study Ingredient testing, designed for real-world application Sequential evaluates active ingredients within controlled base formulations, ensuring results reflect how ingredients perform on human skin. We design studies to isolate and quantify ingredient impact through two core approaches: Active vs control formulations Assess the biological effect of an ingredient against a matched base formulation. Dose-response evaluation Compare different concentrations of the same active to determine optimal performance and efficacy thresholds. By integrating biomarker profiling, microbiome analysis, and clinically relevant endpoints, we generate clear, reproducible insight into ingredient activity. The challenge of validating ingredient performance Demonstrating the efficacy of a novel ingredient is rarely straightforward. Raw actives cannot be meaningfully tested in isolation, yet many studies fail to reflect real-world use within formulations, limiting the relevance of results. Without a structured, comparative study design, it becomes difficult to: isolate the true impact of an ingredient understand dose-response relationships generate credible, claim-ready evidence ingredient impact Understand the true biological effect of your active within a controlled formulation environment. Dose-response clarity Determine optimal concentration ranges through structured comparative study design. Claim-ready evidence Generate robust, biomarker-driven data to support technical documentation and commercial claims.

Participate in Sequential’s skin, scalp, oral and intimate-care microbiome studies. Join our research community and help brands create evidence-based products. Join Our Research Community At Sequential, we’re advancing the science of personal care by testing products for large, industry formulators to ensure that clinically back solutions are presented to consumers worldwide. To do this, we collaborate with individuals who are interested in contributing to cutting-edge research that helps companies and scientists better understand how the microbiome and human biomarkers can impact the health of skincare, scalp care, intimate care and oral care. Why Participate? By joining our participant community, you will: Contribute to meaningful scientific research that drives innovation in personal care and pharma. Support the development of evidence-based products. Receive clear instructions and research updates tailored to each study you join. Help shape the future of personal care science. Participate In A Study First name* Last name* Email* Write a message I agree to the Privacy Policy and consent to data processing. Submit

Discover our team of award-winning scientists dedicated to advancing microbiome research for a healthier world. Explore our expertise now. We are a Team of Award-Winning Scientists Creating a World of Healthier Individuals Our platform is the result of our team’s combined expertise in genetics, epigenetics, and microbiome research. We utilise deep molecular analysis and next-generation sequencing (NGS) technology to understand the impact of product usage on an individual’s microbiome. Through our efforts, we hope to revolutionise the way in which the industry develops and tests its products to deliver optimal results to those utilising them. Our Mission Sequential is the industry leader in clinical human research and testing offering a comprehensive end-to-end platform designed to bring science-backed solutions to the personal care and pharmaceutical industry. Our mission is to understand the impact of the microbiome on the host (humans) and how the host impacts the microbiome in order to characterise human health fully. We offer an extensive platform to conduct research on personal care products through microbiome testing, and biophysical assessments, and offer full recruitment services for studies. We are keen to publish our findings with our partners to increase the literature within this space. At present our database of over 20,000 human microbiome samples is one of the most sophisticated within the industry and is growing rapidly. Innovation Pioneering the forefront of biological science, we consistently introduce groundbreaking advancements to redefine industry standards. Transparency Our commitment to openness ensures a clear understanding of our human microbiome testing processes and analysis. Reliability We guarantee dependable results, fostering trust in the accuracy of our analyses. Our Team at Sequential Oliver Worsley, PhD CHIEF EXECUTIVE OFFICER & CO-FOUNDER Albert Dashi, PhD CHIEF SCIENCE OFFICER & CO-FOUNDER Pétronille Houdart, PharmD SKINCARE DIRECTOR The Commercial Team Derek Butler, PhD MBA COMMERCIAL DIRECTOR Shalindri Jayawardene MSc SCIENCE MARKETING ASSISTANT Carla Brown, PhD, MBA SALES ASSOCIATE Athena Hajaig, BSc MARKETING ASSOCIATE Jaina Bhayani, PhD SALES ASSOCIATE Marya Ahmed, MSc HEAD OF MARKETING The Scientific Team Sibora Peca, MSc CLINICAL OPERATIONS LEAD Omera Bi, PhD, AFHE R&D PROJECT SPECIALIST Grace Robinson, MSc ASSOCIATE SCIENTIST Khanh Lê Đào, BA JUNIOR CLINICAL ASSISTANT Omololu Fagunwa, PhD SENIOR BIOINFORMATICIAN Ami Picari CLINICAL ASSISTANT Sija Sajibu, PhD SENIOR SCIENTIST Behafarid Ghalandari, PhD SENIOR AI SCIENTIST Please find listed a selection of relevant peer-reviewed publications from our advisors. Wu G, TL Dawson, et al. (2015) Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. PLOS Genetics 11(11): e1005614. Chng, K., Nagarajan, N., et al. (2016) Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nat Microbiol 1, 16106. Tay, A.S., Nagarajan, N., et al (2018). 1039 Skin microbiome profiles of atopic dermatitis patients segregate into two community composition types that are stable before and after therapy. Journal of Investigative Dermatology. 138. S176. 10.1016/j.jid.2018.03.1051. Ramasamy S., Barnard, E., Dawson, TL, and Huiying Li. (2019). Role of the skin microbiota in acne pathophysiology. British Journal of Dermatology, https://doi.org/10.1111/bjd.18230. Dawson, TL. (2019) Malassezia: The Forbidden Kingdom Opens. Cell Host Microbe https://doi.org/10.1016/j.chom.2019.02.010 Tay, A.S., Nagarajan, N., et al (2020). Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity. The Journal of allergy and clinical immunology. 10.1016/j.jaci.2020.09.031. Dawson, TL. (2021) Malassezia: A Skin Commensal Yeast Impacting Both Health and Disease. Front. Cell. Infect. Microbiol., doi.org/10.3389/fcimb.2021.659219 Bissonnette, Robert & FAAD, & Palijan, Ana & Salem, Youssef & Maari, Catherine & Proulx, Etienne & Edjekouane, Lydia & Joly-Chevrier, Maxine & Devis, Andrew & Dashi, Albert & Worsley, Oliver. (2024). 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects. Journal of the American Academy of Dermatology. 91. AB224. 10.1016/j.jaad.2024.07.889. Supported By Scientific Board of Advisors Our advisors are world leaders in the skin microbiome and have extensive experience in bringing forward solutions for skin concerns Prof. Tom Dawson Senior Principal Investigator at Skin Research Institute of Singapore. Over 30 years experience in biotechnology innovations, and expert in the skin and hair microbiome. Doctor of Philosophy (PhD), Pharmacology at the Univer sity of North Carolina. Dr Kimberly Capone Dr Kimberly Capone is a pioneer and established expert in microbiology and the human microbiome field where she created new business opportunities across multiple brands over 13 years at Johnson & Johnson Consumer, Inc. Areas of concentration included infant and adult skin, vaginal, gut, and oral health. Prof. Phillip Bennett Phillip Bennett is Professor of Obstetrics and Gynaecology and Director of the Institute of Reproductive and Developmental Biology. Professor Bennett has been one of the key pioneers in researching the vaginal microbiome. In particular, to understand and characterise the impact of the vaginal microbiome on preterm labour. Bennett has published over 400 peer-reviewed research articles over his career. Dr Natalya Fox Dr Natalya Fox is a Dermatologist at the NHS - St George's Hospital, London. Previously, Fox did her MBChB at the University of Edinburgh 201 4 and has her Full MRCP UK in Dermatology. Fox is passionate about the skin microbiome and its place in dermatology. Prof. Elena Lurie-Luke A senior R&D, Innovation and Entrepreneurship Executive with extensive technical, strategic business development. Proven leadership experience in both global FMCG and public health sector environments. Prof. Niranjan Nagarajan Associate Director & Senior Group Leader at Genome Institute of Singapore. Expert in computation biology, in particular the study of microbial communities resident on the human skin. Doctor of Philosophy (PhD), Computer Science at Cornell University. Dr Alexander Lezhava Senior Group Leader & Associate Director at Genome Institute of Singapore. Expert in the commercial development of medical diagnostics and clinical-grade molecular assays. Doctor of Philosophy (PhD), Microbiology at Hiroshima University. Our Labs Sequential has clinical testing labs in New York City, Cambridge and Singapore. Being close to our customers has allowed us to reduce turnaround time, whilst retaining the intellectual property in-house. Supporting World-Class Clients & Partners

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How do I Rebuild my Skin Microbiome? How do I Rebuild my Skin Microbiome? Our skin, as we know to be the body's largest organ, hosts a plethora of microorganisms. An elaborate ecosystem of bacteria, fungi, and viruses that live on the skin and maintain its optimal health, making up the skin microbiome (Smythe & Wilkinson, 2023). These microorganisms serve as a protective barrier against harmful pathogens, aid in immune system regulation, and play a vital role in various skin functions. However, factors such as harsh skincare products, poor diet, and environmental stressors can disrupt the balance, leading to acne, eczema, and other skin disorders (Wallen-Russell, 2019). Restoring the skin microbiome involves a complex and multifaceted approach that includes lifestyle changes, targeted skincare practices, and sometimes dietary adjustments. Understanding the Skin Microbiome The microbiome varies depending on the region of the skin, with different areas hosting distinct microbial communities. Fournière et al. (2020) examine how Staphylococcus epidermidis and Cutibacterium acnes, key skin microbiota components, vary across different skin environments. For instance, Staphylococcus species are mainly in moist areas like axillary and popliteal creases, while Cutibacterium species are found in sebaceous areas such as the face and back. An ideal and healthy skin microbiome is diverse, and resilient, capable of adapting to changes and defending against adversaries. Steps to Restore the Skin Microbiome 1. Use Less & Gentle Skincare Products: Using lesser products would simplify one’s skincare routine, making it easier to stay consistent and therefore allow the skin to adjust and benefit from the active ingredients. Hwang et al. (2021) further suggests that in order to restore the skin microbiome, one should actively choose products with essential ingredients which are natural, soothing and non-disruptive to the skin's natural barrier. 2. Incorporate Probiotics, Prebiotics and Postbiotics: Just as the gut microbiome benefits from probiotics, so does the skin. Probiotic skincare adds beneficial bacteria to restore skin balance, while prebiotics nourish existing good bacteria to boost their growth. Common probiotics include Lactobacillus and Bifidobacteria, found in drinks, powders, tablets, and fermented dairy products (Gowda, et al. 2024). 3. Protect Your Skin from Environmental Stressors: Limit exposure to environmental pollutants and the sun, which can damage the skin barrier and disrupt the microbiome (Wang et al., 2021). Using protective measures like sunscreen, wearing protective clothing, and cleansing your skin regularly can help maintain the integrity of the skin barrier and support a balanced microbiome. 4. Moisturise Regularly: Keeping the skin well-hydrated is crucial for maintaining a healthy microbiome. Dry skin can compromise the skin barrier, making it easier for harmful bacteria to invade. Use a moisturiser that contains ingredients like ceramides, which help to strengthen the skin barrier, and hyaluronic acid to retain moisture. (Spada & Greive, 2018) 5. Pay Attention to Diet: A diet rich in fruits, vegetables, and whole grains supports skin microbiome health with essential vitamins, minerals, and antioxidants. Omega-3 fatty acids, found in fish and flaxseeds, are particularly beneficial as they have anti-inflammatory properties that can help maintain a balanced skin microbiome. (Costantini, Molinari & Merendino, 2017) Conclusion Restoring the skin microbiome is an ongoing process that demands consistent effort and dedication. By understanding the skin microbiome and incorporating strategies to support its health, you can significantly enhance your skin's ability to protect against environmental stressors and lower the risk of skin disorders. References Smythe, P., & Wilkinson, H. N. (2023). The skin microbiome: Current landscape and future opportunities. International Journal of Molecular Sciences, 24(4), 3950. https://doi.org/10.3390/ijms24043950 Wallen-Russell, C. (2019). The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biology, 17(1), 47. https://doi.org/10.1186/s12915-019-0660-6 Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020). Staphylococcus epidermidis and Cutibacterium acnes: Two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms, 8(11), 1752. https://doi.org/10.3390/microorganisms8111752 Hwang, B. K., Lee, S., Myoung, J., Hwang, S. J., Lim, J. M., Jeong, E. T., Park, S. G., & Youn, S. H. (2021). Effect of the skincare product on facial skin microbial structure and biophysical parameters: A pilot study. MicrobiologyOpen, 10(5), e1236. https://doi.org/10.1002/mbo3.1236 Gowda, V., Sarkar, R., Verma, D., & Das, A. (2024). Probiotics in Dermatology: An Evidence-based Approach. Indian dermatology online journal, 15(4), 571–583. https://doi.org/10.4103/idoj.idoj_614_23 Wang, L., Xu, Y. N., Chu, C. C., Jing, Z., Chen, Y., Zhang, J., Pu, M., Mi, T., Du, Y., Liang, Z., Doraiswamy, C., Zeng, T., Wu, J., & Chen, L. (2021). Facial Skin Microbiota-Mediated Host Response to Pollution Stress Revealed by Microbiome Networks of Individual. mSystems, 6(4), e0031921. https://doi.org/10.1128/mSystems.00319-21 Spada, F., Barnes, T. M., & Greive, K. A. (2018). Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, cosmetic and investigational dermatology, 11, 491–497. https://doi.org/10.2147/CCID.S177697 Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017). Impact of Omega-3 Fatty Acids on the Gut Microbiota. International journal of molecular sciences, 18(12), 2645. https://doi.org/10.3390/ijms18122645

How do you Formulate Skincare Products? How do you Formulate Skincare Products? Formulating skincare products is a process that combines different ingredients to provide targeted skin benefits. The type of product being used, the particular skin concern and the formulation's stability and effectiveness are some of the variables that can affect the formulation process. Key Components of Skincare Formulation: Choosing the right ingredients when formulating skincare products is important, as it determines the product's effectiveness. Moreover, the chemical composition of the ingredients and their concentrations in a formulation is as important as establishing its overall effect on our health. Most skincare products typically include 15 to 20 ingredients in their formulation (Goyal & Jerold, 2023). Water Ultra-pure distilled water serves as the foundation for nearly every cosmetic formulation, including creams, lotions, makeup, deodorants, shampoos, and conditioners. It functions primarily as a solvent, helping to emulsify ingredients and ensure a smooth and consistent texture in the final product (Goyal & Jerold, 2023). Emulsifiers Promotes the formation of a homogenous and consistent texture in the formulation by encouraging the suspension of water and oil (Goyal & Jerold, 2023). Humectants Humectants are crucial for the skin's hydration balance, moisture retention, and desiccation prevention. Multiple hydroxyl, carboxyl, or other polar groups found in humectants have the ability to create hydrogen bonds with water molecules, which allows them to absorb and hold onto moisture (Du et al., 2024). Thickeners Long carbon chains and polar groups like hydroxyl, carboxyl, and amide groups make up most of the thickeners. Within solutions, these long-chain structures increase the viscosity of the solution by increasing its resistance to flow (Du et al., 2024). Preservatives Preservatives are added to prevent the growth of pathogenic and non-pathogenic microorganisms that could degrade the product or negatively impact the consumer's health De et al., 2017). Active Ingredients Ingredients that offer therapeutic advantages and improve the efficacy of skincare products, such as hyaluronic acid, are used as active components in formulations (Morganti et al., 2023). Therefore, selecting the appropriate active ingredient is crucial to creating a high-quality skin care product (Calixto & Maia, 2017). Stability testing and sensory analysis The formulations afterwards need to be tested for their stability at different temperatures and for sensory evaluation such as spreadability, cohesiveness, consistency, firmness and viscosity (Calixto & Maia, 2017). Targeting the microbiome with Skincare products Our skin is home to millions of microbial species called the Skin microbiome. A balance of all these microbes is crucial to obtain healthy skin. Imbalances cause several skin problems such as acne, rosacea…etc. So when formulating skincare products it is important to investigate each ingredient's impact on the skin microbiome. Conclusion It is of great importance to carefully consider the ingredients that are put into skincare formulations whilst considering the skin microbiome. Developing safe and efficient products is frequently the main goal, there is also a growing tendency towards customisation based on the demands of each individual's skin. This trend towards customised skincare highlights the value of customised solutions in the beauty industry and represents a deeper awareness of the various needs of various skin types and conditions. References Calixto LS, Maia Campos PMBG. Physical-Mechanical characterization of cosmetic formulations and correlation between instrumental measurements and sensorial properties. Int J Cosmet Sci. 2017 Oct;39(5):527-534. doi: 10.1111/ics.12406. Epub 2017 Jul 24. PMID: 28555924. De Groot, A. C., & White, I. R. (2001). Cosmetics and Skin Care Products. Textbook of Contact Dermatitis, 661–685.doi:10.1007/978-3-662-10302-9_32 Du XN, He Y, Chen YW, Liu Q, Sun L, Sun HM, Wu XF, Lu Y. Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology. Molecules. 2024 Jan 15;29(2):411. doi: 10.3390/molecules29020411. PMID: 38257324; PMCID: PMC10818968. Goyal N, Jerold F. Biocosmetics: technological advances and future outlook. Environ Sci Pollut Res Int. 2023 Feb;30(10):25148-25169. doi: 10.1007/s11356-021-17567-3. Epub 2021 Nov 25. PMID: 34825334; PMCID: PMC8616574. Morganti, P.; Lohani, A.; Gagliardini, A.; Morganti, G.; Coltelli, M.-B. Active Ingredients and Carriers in Nutritional Eco-Cosmetics. Compounds 2023, 3, 122-141. https://doi.org/10.3390/compounds3010011

What are the Best Microbiome Tests? What are the Best Microbiome Tests? As interest in the human microbiome grows, various microbiome tests have emerged, each offering unique insights into our health. Understanding which tests are best suited for individual needs can help inform decisions regarding health management and lifestyle changes. Skin Microbiome Testing Skin microbiome testing involves collecting samples from the skin's surface using methods like swabs, tape strips, or skin scrapings to analyse the diversity and composition of microorganisms residing on the skin. The samples are then processed through DNA sequencing techniques to identify microbial species and their relative abundance. This testing provides insights into how the skin's microbial ecosystem impacts health conditions such as acne and eczema. Skin microbiome research is increasingly being used to develop personalised skincare products and therapeutic approaches. (Byrd et al., 2018) Stool Microbiome Testing Stool testing remains one of the most common and accessible methods for analysing the gut microbiome. These tests evaluate the diversity and abundance of microbial species, helping to identify imbalances linked to conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and obesity. A study by Zhernakova et al. (2016) emphasises the utility of stool microbiome tests in detecting dysbiosis and understanding its relationship to health outcomes. Saliva Microbiome Testing Saliva microbiome testing is another non-invasive method, focusing on the oral microbiota. This test can provide insights into oral health, periodontal disease, and even systemic health conditions linked to the oral microbiome. A study by Aas et al. (2005) illustrates that the oral microbiome reflects changes in health status, making saliva testing an essential tool for early disease detection. Blood Microbiome Testing While less common, blood microbiome testing is gaining traction, especially for identifying systemic infections or chronic conditions. This testing method analyses microbial DNA present in the bloodstream, which can reveal insights into conditions like sepsis and cardiovascular diseases. A paper by Cheng et al. (2023) reviews the emerging concept of the blood microbiome, highlighting its potential role in human health and disease, while addressing existing controversies and the need for further research to understand its clinical implications. Tissue Biopsy Microbiome Testing Tissue biopsies are increasingly utilised for studying the microbiome within specific organs, particularly the gastrointestinal tract. This method allows for direct analysis of microbial communities in tissue samples, providing insights into diseases such as colorectal cancer and IBD. Recent advancements in next-generation sequencing have enhanced the ability to identify and characterise microbial populations in biopsies, as noted by Schulfer and Blaser (2015). Conclusion Choosing the right microbiome test depends on individual health concerns and goals. Stool and saliva tests are excellent for general gut and oral health insights, while blood and tissue tests offer deeper analysis for chronic diseases. As research continues to evolve, these tests will likely become even more integral to personalised healthcare and preventative strategies. References Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005). Defining the normal bacterial flora of the oral cavity. Journal of Clinical Microbiology, 43(11), 5721-5732. https://doi.org/10.1128/JCM.43.11.5721-5732.2005 Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143-155. https://doi.org/10.1038/nrmicro.2017.157 Cheng, H. S., Tan, S. P., Wong, D. M. K., Koo, W. L. Y., Wong, S. H., & Tan, N. S. (2023). The blood microbiome and health: Current evidence, controversies, and challenges. International Journal of Molecular Sciences, 24(6), 5633. https://doi.org/10.3390/ijms24065633 Schulfer, A., & Blaser, M. J. (2015). Risks of antibiotic exposures early in life on the developing microbiome. PLoS Pathogens, 11(7), e1004903. https://doi.org/10.1371/journal.ppat.1004903 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., ... & Wijmenga, C. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369

< Back Marketing Associate Cambridge, UK Job Type Full-time Workspace Hybrid About the Role As a Marketing Associate at Sequential, you will play a critical role in shaping our brand, product (s) and ensuring our scientific expertise is communicated to the personal care and dermo-cosmetics industries. You will support the execution of marketing strategies that drive awareness, engagement and lead generation efforts to amplify Sequential’s footprint and contribute to commercial growth. Working closely with the Head of Marketing and cross-functional teams, you’ll help bring Sequential’s unique value proposition to life across digital channels, campaigns and tradeshows (+ conferences). This is an exciting opportunity for a creative, detail-oriented marketer to gain hands-on experience in a fast-growing biotech company at the forefront of microbiome and human biomarker testing innovation. An ideal candidate should have the drive to quickly learn our scientific offering to be able to translate them into strong marketable assets. We are looking for someone who will hit the ground running and be able to integrate into the team seamlessly. 3-6 months into the role, we expect a concrete understanding of our offerings, the ability to support in marketing efforts, and have ownership of individual duties and tasks to ensure smooth execution of overarching marketing strategies. Our end clients are B2B companies who operate in both personal care and pharma industries. Both these target groups require different marketing tactics to reach. In order to succeed within this role, a deep understanding of these industries, their pain points and objections will be critical. Essential Duties and Responsibilities: ●Marketing Campaign Support: Assist in the execution of marketing campaigns across digital, email, and content channels to support business and sales objectives. ●Content Development: Help create and coordinate marketing materials including website content, blog posts, email newsletters, social media content, presentations, and sales enablement assets. ●Brand and Messaging Alignment: Ensure all marketing materials are consistent with Sequential’s brand voice, positioning, and scientific credibility. ●Market and Customer Research: Support in conducting research on industry trends, customer needs, and competitor activity to inform marketing strategies and messaging. ●Digital Marketing & Analytics: Support website updates, email campaigns, and social media efforts; track performance metrics and assist in reporting insights. ●Support with Ads Strategies: Support with Google Ads and LinkedIn Ads to increase website traffic and lead generation form submissions. ●Cross-Functional Collaboration: Work closely with sales, product, and operations teams to ensure marketing initiatives align with commercial goals and customer needs. ●Product and Scientific Knowledge: Develop a strong understanding of Sequential’s offerings and the microbiome and human biomarker landscape to effectively communicate value to target audiences. Qualifications and Experience: ●1–2 years of experience in marketing, communications, or a related role; experience in biotechnology, life sciences, or cosmetics is preferred. ●Working knowledge of Canva for brand-aligned digital content creation is essential. ●Quick to learn scientific concepts as a large part of the role consists of taking complicated science and translating it into tangible benefits for the industry. ●Familiarity with digital marketing tools LinkedIn, Google Ads & Analytics, Hubspot, Wix & Meta Ads is preferred. ●Excellent written and verbal communication skills with an eye for detail and storytelling. ●Creative mindset paired with analytical thinking and comfortable thinking out of the box and owning small projects. ●Bachelor’s degree in Marketing & Communications (or equivalent) with a strong interest in the pharma, dermo-cosmetics, personal care industry. ●Highly organized self-starter with the ability to work on multiple projects in a fast-paced environment. ●Collaborative, adaptable, and eager to learn in a growing company. What You Get from Us: • A competitive base salary with opportunities for growth as the company scales. • Access to our Equity Incentive Plan, allowing you to grow alongside Sequential. • Hands-on experience working with industry experts in a rapidly expanding biotech sector. • The opportunity to help shape the brand of a company advancing microbiome science and its real-world applications. About the Company Sequential is an established global leader in clinical product testing for the personal care and dermo-cosmetics industries. Formed by a team of PhD experts in genetics, epigenetics, and microbiome research, the company specializes in microbiome and human biomarker testing to champion topical products’ impacts in real use cases across skin scalp, oral and vulvovaginal formulations. The company is an Innovate UK and Enterprise Singapore-backed company, with labs in Cambridge, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 50,000 human skin microbiome samples and corresponding formulations tested clinically. With this vast genomic dataset, Sequential is figuring out optimal formulations that could potentially alleviate skin conditions, such as for acne, atopic dermatitis and rosacea. The company has been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $5MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology. Apply Now