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< Back Sales Associate (NYC Based) New York, NY, USA Job Type Full-time Workspace Hybrid About the Role As a Sales Associate at Sequential, you will be essential in building relationships and expanding our reach within the personal care and dermocosmetic industry. Your role will involve supporting business development efforts, assisting in sales strategy execution, and helping grow market share for Sequential’s innovative products and services. You will work closely with the Commercial Director and team to meet sales goals, develop client relationships, and contribute to Sequential’s mission of advancing microbiome science. This is a fantastic opportunity for an ambitious sales professional to gain hands-on experience and make a tangible impact in a rapidly growing biotech field. Essential Duties and Responsibilities: Sales Support and Development: Assist in the identification and acquisition of new customer accounts, supporting the growth of Sequential’s client base. Client Relationship Building: Cultivate relationships with existing and prospective clients, focusing on understanding their needs and promoting Sequential’s unique offerings. Market Research: Conduct ongoing research to stay informed on industry trends and competitor activity, providing valuable insights for sales strategies. CRM and Data Management: Maintain accurate records in our CRM (HubSpot), tracking interactions, progress, and key performance indicators. Sales Target Achievement: Work towards defined sales goals, contributing to Sequential’s revenue targets and growth ambitions. Collaborative Efforts: Work closely with marketing, product, and operations teams to align efforts and ensure a seamless customer experience. Product Knowledge Development: Stay up-to-date on Sequential’s product offerings and the latest microbiome research to effectively communicate value to clients. Qualifications and Experience: 1-2 years of sales experience, ideally within the biotechnology, cosmetics, or life sciences fields. Familiarity with CRM systems, preferably HubSpot, and the ability to manage data with accuracy. Strong written and verbal communication skills with a passion for client interaction and customer service. Tech-savvy and eager to leverage technology to enhance sales effectiveness. Bachelor's degree in Life Sciences, Business, or a related field preferred; demonstrated interest in microbiome or biotechnology is a plus. Motivated self-starter with a goal-oriented mindset and excellent organizational skills. Ability to work collaboratively and adapt in a dynamic, fast-paced environment. What You Get from Us: A base salary with a commission structure that rewards your hard work and success. Access to our Equity Incentive Plan, allowing you to grow alongside Sequential as we expand. The chance to work with industry experts in one of the fastest-growing sectors within biotechnology. Be part of a company at the forefront of microbiome research, making an impact in the personal care and dermocosmetic fields. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $5MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now

Sequential is honoured to be spoken and written about in numerous publications. We are always keen to speak about the great milestones we are hitting with our personal care microbiome testing platform. Sequential in the Press Science-led minimalism shapes future sustainable skin care 13-Jan-2026 Read Now Beautiful Bacteria: Are We On The Cusp Of Microbiome Mainstreaming? 28-Sep-2025 Read Now Sequential Skin and AMILI Secure $1.8M UK-Singapore Grant to Advance Gut-Skin Microbiome Science 14-Feb-2025 Read Now 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects Sep-2024 Read Now Is Microbiome Certification even Necessary? 29-Jul-2024 Read Now ‘It’s a really delicate system’: Research on vaginal microbiome shows how little we know about femcare 22-Jan-2024 Read Now Gallinée lance le premier test de santé de la peau et du microbiome à réaliser chez soi 10-Oct-2023 Read Now Lysine-dendrimer: a gentle yet effective acne treatment that maintains skin microbiome, says study 18-Aug-2023 Read Now Acne and ageing: J&J exploring skin health markers via Sequential Skin research tie-up 15-Mar-2023 Read Now Sequential Skin x Johnson & Johnson Collab to Quantify Skin Health 14-Mar-2023 Read Now Understand before purchase: Microbiome testing can help consumers find the right products and eliminate waste 30-Jan-2023 Read Now Sequential Wins New Grant To Propel Skin Microbiome Research 30-Jun-2022 Read Now Sequential Skin launches test to assess ingredient effect on microbiome 22-Mar-2022 Read Now Microbiome start-up Sequential Bio debuts first in-vivo testing for personal care industry 04-Mar-2022 Read Now Sequential Skin Raises $1.6M in Oversubscribed Seed Round 12-Oct-2021 Read Now The skin microbiome brainstorm: Tech, claims and trend-driven NPD 16-Sep-2021 Read Now Skin Sensors Enable Personalized Skin Care 20-Aug-2020 Read Now Sequential Skin: beauty tech’s new approach to genetic analysis and microbiome skincare 09-Mar-2020 Read Now How genetic insights can personalise skin microbiome launches 29-Jul-2019 Read Now Deep dive into Radiance Evaluation 9-Oct-2025 Read Now Men’s care shifts toward function-first to address skin needs beyond the basics 16-Sep-2025 Read Now Sequential and AMILI secure $1.8M UK-Singapore R&D project to advance gut-skin microbiome science 13-Feb-2025 Read Now New clinical testing to “investigate microbial roots of various skin conditions” 17-Oct-2024 Read Now Losing its meaning? ‘Microbiome-friendly’ terms at risk of misleading consumers – Sequential CEO 29-Jul-2024 Read Now Navigating the realm of intimate care products 17-Jan-2024 Read Now Avec ce test microbiome maison, 10 secondes m'ont suffit pour découvrir les besoins de ma peau 04-Oct-2023 Read Now Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin 3-Aug-2023 Read Now Sequential Announces New Collaboration Agreement to Measure Skin Health for Leading Developer of Personal Care Products 15-Mar-2023 Read Now Sequential Skin partners with Johnson & Johnson on microbiome tests 10-Mar-2023 Read Now Symbiome Partners with Skin Microbiome Testing experts at Sequential to Revolutionize Beauty Industry 26-Jan-2023 Read Now Sequential Skin Nabs $500K UK Grant to Study Skin Microbiome in Atopic Dermatitis 29-Jun-2022 Read Now Demands rising for clinical data on the skin microbiome: Experts 22-Mar-2022 Read Now ‘Maintaining the microbiome’: Biotech startup Sequential Skin debuts in vivo B2B testing service 03-Mar-2022 Read Now Start-up Sequential Skin bags $1.65m of fresh funding 12-Oct-2021 Read Now Singapore Beauty Startup Sequential Skin Uses Science to Help Identify the Best Skincare For You 07-Jan-2021 Read Now Overlooked opportunities? Skin microbiome may play a more important role in personalisation than DNA 13-Aug-2020 Read Now Sequential tool kit prioritises personalisation 15-Jan-2020 Read Now Sequential: Testing shows skin microbiome plays a role in hyperpigmentation 7-Oct-2025 Read Now The bidirectional skin-gut microbiome: a game-changer for cosmetic formulators 29-Jul-2025 Read Now Sequential and AMILI Secure Prestigious $1.8M UK-Singapore Collaborative R&D Project 13-Feb-2025 Read Now Sequential Launches Industry-First Microbiome Target Panels for Skin Conditions 16-Oct-2024 Read Now From the experts: Top 3 trends in skin microbiome research 20-Jun-2024 Read Now Is Home-Based Skin Microbiome Testing Transforming Beauty and Health Care Industry? 7-Dec-2023 Read Now “Hormone-led changes cause differences to the vaginal ecology that can have an effect on women’s health later in life.” CEO of Sequential 13-Sep-2023 Read Now Sequential and Johnson & Johnson enter partnership to develop new genomic-based skin test 16-Mar-2023 Read Now Sequential Announces New Collaboration Agreement to Quantify Skin Health 15-Mar-2023 Read Now ‘Natural evolution’: Gallinée unveils at-home skin microbiome test kits with Sequential Skin 09-Mar-2023 Read Now Here They Are: Congratulations to the Winners of the 2022 C&T Allēs 29-Sep-2022 Read Now Sequential Skin: Why We Invested 11-Apr-2022 Read Now Sequential Skin Debuts Sequential Bio Testing Solution 09-Mar-2022 Read Now Biotech Start-Up Sequential Skin Raises Funds 10-Dec-2021 Read Now Biotech startup Sequential Skin raises €1.4m – ‘We want to accelerate the future of skin health,’ says CEO 11-Oct-2021 Read Now PODCAST – Holistic view on skin: Sequential Skin on why microbiome testing is crucial to personalised beauty 21-Aug-2020 Read Now Beauté personnalisée: Sequential Skin la Beauty Tech made in Singapore 07-Jul-2020 Read Now GWS 2019 DAY 2 Beauty, Science & Technology: Skin in the Game 25-Nov-2019 Read Now

Throughout the year, Sequential has the pleasure of going to various conferences and trade shows where we talk all things microbiome testing and clinical studies. Don't miss us when we're in your city next! Connect With Us At Conferences At Sequential, we believe in the power of personal connections and the exchange of ideas to foster innovation and growth. As we actively participate in various conferences and industry events, we invite you to be a part of these enriching experiences. Explore the opportunities to engage with our team, discover the latest industry trends, and strengthen the bonds that drive mutual success. Join us at conferences to connect, learn, and pave the way for future collaborations. Where we will be in 2026 2-4 March Cambridge, United Kingdom 18-19 March Copenhagen, Denmark 14-16 April Paris, France 19-20 May New York City, USA 14 July Liverpool, United Kingdom 28 September - 1 October Perth, Australia 10-11 November Coventry, United Kingdom Microbiome Interactions in Health and Disease Our CEO & Co-founder, Dr. Oliver Worsley, will have the pleasure of attending this year. Microbiome Times Partnering Forum We are incredibly excited to be part of this forum, where we get to discuss with experts in the industry. In-cosmetics Global Have the pleasure of exhibiting and presenting at In-cosmetics Global. Come visit us at Booth (1A64) and listen to our CEO & Co-founder, Dr. Oliver Worsley, speak on “Advancing Personal Care Claims with integrated Human and Microbiome Data” on 14th April, Theatre 3 – 15.05 - 15.35. NYSCC Supplier's Day We are back at New York Supplier’s Day! (Booth information TBA) SCS Conference We will be attending the SCS Conference and look forward to connecting with industry peers. IFSCC Congress We are pleased to be attending the IFSCC Congress, engaging with the global cosmetics science community. SCS Formulate Visit us at Booth (600) at this year’s SCS Formulate to learn more about our work and speak with the team. Connect with us on Socials!

Seeking formulation support? Embark on the journey to your next best-selling product with our assistance. Let's collaborate and create success together! Create Your Next Best-Selling Formulation A well-designed formulation takes into account the diverse and delicate ecosystem of the microbiome. By incorporating ingredients that promote a harmonious relationship with the microbiota, such as prebiotics and postbiotics, a product can positively impact the microbial diversity and balance on the body. Having collected over 20,000+ human skin microbiome samples through in vivo clinical research, we can help you take your product from conception to completion. Consultation Book a consultation to start creating your microbiome supporting formulation. Whether you need help starting out or are already in the midst of your process, we can support you. INCI List Examination Have an INCI list and are unsure if it will be a formula? No need to look further, we will gladly look through your proposed INCI list and revert back with feedback. Co-Develop Let us be your Chief Science Officer, or your scientific advisory, and leverage our dataset for the co-development of products that suit your demographic and application. SKINCARE FORMULATIONS Regular to Atopic Skin, Start Formulating Today! What Contributes to a Microbiome Supporting Formulation? When creating a product that "maintains the microbiome", it is crucial to understand that every ingredient used is important. Hero ingredient-led philosophy cannot be applied in the formulation process as it is the blend of each ingredient that will create a product to support and improve the balance of the skin microbiome. Fermented ingredients (postbiotics) and those that act as food for microbes (prebiotics) are also known to have a positive impact on formulations when paired with the right preservative systems, surfactants, emollients, etc. It is still rare to find live bacteria (probiotics) in formulations, however, if encapsulated correctly, it could show improvement in the microbiome balance. Prebiotics Prebiotics beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria on the skin, and thus improves host health. Prebiotics act as food for the microbes on the skin, and allow good bacteria to grow and thrive. Probiotics Probiotics are living microorganisms that confer benefit to the host when applied to the body. Because probiotics are live bacteria, it is incredibly difficult to preserve and put into skincare products (especially when skincare contains preservatives). In fact, some products on the market that say they use probiotics, are actually using prebiotics or postbiotics. Postbiotics Postbiotics are the byproduct of fermented live bacteria (probiotics) or inactivated microorganisms. The process of fermentation releases nutrients inside of the bacteria and holds concentrated and nourishing skin health benefits that help to balance the skin microbiome. INGREDIENTS FROM MICROBIAL ORIGIN No INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? No Yes Yes ARE THEY VIABLE? No Yes ORIGIN VIABILITY FUNCTION ORDINARY INGREDIENT ORDINARY INGREDIENT WITH PREBIOTIC FUNCTION INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? PROBIOTIC INGREDIENT No POSTBIOTIC INGREDIENT Yes POSTBIOTIC INGREDIENT WITH PREBIOTIC FUNCTION Our Leading Expert & Skincare Director Pétronille Houdart A pharmacist by training, Pétronille specialized in dermo pharmacy and cosmetology. She has garnered extensive experience in the formulation of cosmetic products and is passionate about skincare. She started her career working for a private-label contract manufacturer that focused on custom cosmetic formulations for clients ranging from big brands to private dermatologist products. She has previously created a high-performance customisable formulation brand and is vocal about bespoke and innovative cosmetic formulations. Request a Consultation Ashfi Rahman, Co-founder at HonestStory "Sequential gave us completely essential consulting work on microbiome skincare formulations. They are the only company out there that combines their knowledge of microbiome testing with formulation expertise, and we're very happy to be working with them to develop the first microbiome skincare in India." FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Sequential provides advanced microbiome testing for personal care products, delivering actionable insights to enhance product efficacy and consumer trust. Human Clinical Testing. Biomarker Discovery. Next-generation Formulations. What We Offer From study design and participant recruitment to laboratory analysis and data interpretation, Sequential delivers an end-to-end, in-house solution for understanding how products interact in real use cases. Our clinically relevant insights translate complex microbial and molecular data into clear, actionable outcomes empowering companies to develop products that are credible, effective, and trusted by consumers. See How We Can Help 50,000+ Microbiome Sample Database 4,000+ Ingredient Database 10,000+ Testing Participants Globally 100+ Industry Partners Supporting World-Class Clients & Partners Join Our Partners! What Our Clients Say “Sequential is one of the world’s most innovative Microbiome companies. The resolution at subspecies level, and to perform quantification of key vaginal microbes, in vivo , was exactly what we wanted at Curive Healthcare to know intricately how our product is working to improve women’s health.” - Matthew Line, Chief Marketing Officer at Curive Healthcare

Are you looking to test your formulation through the lens of the microbiome? Sequential is the partner you need to structure your study, recruit participants and analyze your results with our sequencing reports.

Thank you for getting in touch! We will review your query and get back to you within 1-2 business days.

What Is a Skin Microbiome Kit? What Is a Skin Microbiome Kit? A skin microbiome test kit is a diagnostic tool designed to analyse the microorganisms living on the surface of the skin. These kits assess the diversity and abundance of bacteria, fungi, and other microbes, providing insights into the skin’s microbial ecosystem. The information gathered can help individuals and healthcare providers understand microbial imbalances that might contribute to dermatological conditions or identify strategies to improve skin health. Components of a Skin Microbiome Kit Sampling Materials Swabs: Sterile swabs are used to collect skin samples from specific areas, such as the face, hands, or scalp. Adhesive Strips: In some kits, tape-stripping methods collect deeper microbial samples by gently removing skin cells along with surface microbes. Sample Preservation The collected samples are placed into a vial or test tube containing a stabilising agent to preserve the DNA of microbes until the sample reaches the laboratory. Instructions for Use Clear instructions are included to guide users on how to collect samples correctly to avoid contamination and ensure accurate results. Once the sample arrives at the lab, it undergoes next-generation sequencing (NGS) or polymerase chain reaction (PCR) analysis. These techniques identify microbial DNA and quantify the presence of various microorganisms. (Nafea et al., 2024) Results are typically shared in reports, offering detailed insights into the composition of the user’s skin microbiome and recommendations for skincare or lifestyle adjustments. Applications and Benefits -Personalised skincare: Tailored treatments based on an individual’s skin microbial profile. By identifying specific bacteria or fungi, users can specifically customise their skincare routines, using products designed to promote a healthy microbiome or address specific concerns such as acne or dryness. Companies may also use the microbiome data collected to formulate more effective skincare products in the future. -Identifying dysbiosis: Kits can detect microbial imbalances (dysbiosis), which are associated with conditions such as eczema, acne, and psoriasis. (Borrego-Ruiz & Borrego, 2024) This allows dermatologists to recommend targeted therapies, such as probiotics or prebiotics, to restore balance and improve skin health. (D’Auria et al., 2021) They are also helpful for tracking the effectiveness of treatments over time. -Monitoring the impact of lifestyle changes: The skin microbiome is influenced by environmental factors like humidity, pollution, and UV exposure, as well as lifestyle choices such as diet and stress management. Testing allows users to monitor how these factors affect their microbial health and make adjustments accordingly. (Byrd et al., 2018) -Research purposes: Helping dermatologists and researchers understand the dynamics of skin health better and test the effectiveness of new treatments. This data can drive the development of these new therapies, including microbiome-based interventions, and help identify potential biomarkers for skin disorders. (D’Auria et al., 2021) Scientific Significance The skin microbiome plays a crucial role in maintaining the skin's barrier function and immune responses. Imbalances in these microbial communities are often associated with dermatological conditions, and research continues to explore how restoring balance through topical or oral interventions could improve skin health. Accurate sampling and analysis, however, remain critical challenges for researchers, requiring reproducible methods for reliable results. (D’Auria et al., 2021) Conclusion A skin microbiome kit offers a gateway into understanding the complex ecosystem on our skin. While still emerging as a mainstream tool, these kits are becoming popular in both consumer skincare and clinical research. As more studies focus on the interplay between the skin microbiome and external factors such as diet and environmental exposures, personalised skincare routines may soon become the norm. References Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143-155. https://doi.org/10.1038/nrmicro.2017.157 Borrego-Ruiz, A., & Borrego, J. J. (2024). Microbial Dysbiosis in the Skin Microbiome and Its Psychological Consequences. Microorganisms, 12(9), 1908. https://doi.org/10.3390/microorganisms12091908 D'Auria, E., Acunzo, M., et al. (2021). A journey on the skin microbiome: Pitfalls and opportunities. International Journal of Molecular Sciences, 22(18), 9846. https://doi.org/10.3390/ijms22189846 Nafea, A. M., Wang, Y., Wang, D., Salama, A. M., Aziz, M. A., Xu, S., & Tong, Y. (2024). Application of next-generation sequencing to identify different pathogens. Frontiers in Microbiology, 14. https://doi.org/10.3389/fmicb.2023.1329330

Certify your skincare product with us! Maximise microbiome benefits in your strategy. Let's start today for success! Skin Microbiome Testing As the skincare industry grows, consumers demand transparency from the brands formulating their products. It has become essential for formulators to create products they are willing to test to present scientifically backed data-driven evidence of their products' true effects. Sequential offers microbiome testing for your skincare formulations, ranging from moisturizers, serums, cleansers, SPF products, etc. We are dedicated to understanding how your product interacts with the skin and its microbes. Depending on how in-depth you want to go, we offer qPCR, 16S, ITS, and Shotgun Metagenomics. Download Case Study! Personalized Approach to Testing Unlike other methodologies present within the industry, Sequential's approach ensures that your product's data and analysis will stand the test of industry regulations when they are introduced. You can tailor your study entirely to your unique requirements. Test Products in a Real-Life Context The microbiome comprises a complex ecosystem of microorganisms that live together in a delicate balance, which is why it's best to test directly upon it directly. To fully understand the impact a product is having on the microbiome, in vivo is the only way. Collect Longitudinal Data With in vivo testing we can design your study around the extended use of a product over multiple time points. This allows us to review how a product is performing before and after usage, but also take into account its gradual impact on the microbiome. Measure Against a Control Group Measure a product against a control group that might have a different percentage of your active ingredient within its formulation or no active at all. This will allow for deeper insights into the impact of a formulation on microbial balance and diversity. 4 Sequencing Reports To Pick From Depending on your development stage and what you are interested in studying we offer qPCR, 16S, ITS, and Shotgun Metagenomics. With our qPCR Smart Probes™ we can go down to the strain level in our analysis. Personalize Your Microbiome Study! The body's skin surface consists of the largest organ within the human body, hosting trillions of microbes (bacteria, viruses, fungi, etc.). These microbes protect the body from external forces, playing a key role in systemic human health. Clinically Validated Collection System In addition to skin swabs, at Sequential we have developed another strong innovation to collect reliable, reproducible, and straight forward skin samples - making it that much easier to do remote consumer and clinical studies. - Validated with external parties for DNA and RNA collection, both from microbial and host cells. - Published in peer-reviewed journals, showing ease of collection and adoption for clinical studies in a range of studies. -Clinically tested on 7 unique body sites. Smart Probe s ™ Our dedicated team of scientists have developed a method of evaluating microbes through our Smart Probes™. These refer to a panel of 20 key microbes we have specifically identified as having the most impact on skin health. Over and above the taxonomic characterisation that 16S offers, which gives us a snapshot of all the genus present within a collected sample (Cutibacterium, Staphyloccocus, etc.) our targeted approach takes it a step further, opening the lens to the species (C. acnes ), sub-species (C. acnes defendens ) and even strains within them. This is a crucial distinction as not all strains of a species behave similarly. In Fact, we find that within these species there are strains associated with inflammation and strains that are commensal, and beneficial. Gold Standard Certification Sequential has developed the gold standard test for products designed to target the microbiome, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. Using next-generation sequencing of the collection of micro-organisms found on the body, before and after product usage, Sequential investigates the microbial balance and diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. We give you an in vivo certification that your product maintains the microbiome. And it’s not exclusive to skincare! We do this for haircare products, oral products, and vulva/vaginal microbiomes. Personalize Your Microbiome Study! Supplement Your Microbiome Study Recruitment Services Let us take care of the entire candidate recruitment process for you! View More Biophysical Assessments Increase your data on the use of your product by evaluating additional biophysical factors. View More Formulation Support Seek consultation advice for your formulation if you are re-formulating or developing a new product. View More FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

The ingredient list for our Biome Mask formulation with each of their applications from giving deep hydration to protecting from pollutants with antioxidant benefits. Category Ingredient What is it? Benefit Melanin Targeters Arbutin Arbutin is an antioxidant that is extracted from different berries. Arbutin helps in ensuring that skin is brightened and pigmentation is reduced in the skin. It can also fade scars. Hydrators Squalane Squalane is a hydrogenated version of squalene. It is an emollient and behaves similar to our own skin sebum. Prevents moisture loss, can neutralize UV damage . Postbiotics Lactobacillus ferment Lactobacillus ferment is a non-living probiotic ingredient made by fermentation of the microorganism Lactobacillus. Thanks to its soothing effect on the skin, it helps to strengthen the skin's defense and maintains the health of the skin microbiome. Allantoin Allantoin is an extract from comfrey plant. Allantoin protects and soothes the skin. Trehalose Trehalose is a disaccharide with hydrating properties for the skin. It’s a plant sugar. Trehalose is used as a prebiotic and is effective to help maintain healthy skin. Green Tea Extract Extract from the leaves of green tea. Tea Extracts is an antioxidant ingredient that aids soothing the skin and can also address skin discoloration and early signs of aging. Colloidal Oatmeal Colloidal Oatmeal is cocktail of oats that has been refined into powder and acts as a skin protectant. Colloidal Oatmeal aids in locking in moisture in the skin barrier and also has soothing properties. Skin Soothing Multi-Ceramide [Ceramide NP; Phytosphingosine] Ceramides are lipids or fats that exist in skin cells and make up to 40% of your outer skin layer. Ceramides are crucial in aiding your skin to retain moisture and prevent unwanted bacteria from entering your body. Skin Repairing Peptide Complex [copper tripeptide-1, Acetyl heaxapeptide-8, Palmitoyl Pentapepdide-4, Palmitoyl tripeptide-1, Palmitoyl tetrapepide-7, tripeptide-1, tripeptide-2, tripeptide-2, tripeptide-3, acetyl Octapeptide 3] Peptides are amino acid chains that aid in the forming of certain types of protein in the skin such as elastin and collagen. Peptides can help in increasing skin elasticity and reducing signs of aging, allowing skin to appear firmer. Skin Shields Vitamin E [Tocopherol] Tocopherol is an excellent example of a powerful antioxidant that is oil-soluble, meaning it can easily dissolve into the skin. Tocopherol helps in combating free-radical damage (such as pollution), and can also be an effective hydrator. Retinyl Palmitate Retinyl Palmitate is the most abundantly used form of retinol (Vitamin A). Retinyl Palmitate has anti-aging properties as well as anti-oxidant properties. Centella Asiatica Centella Asiatica is a medicinal herb that is known to treat inflammation and has antioxidant properties. Centella Asiatica is used as an active ingredient in skincare products for anti-inflammation, anti-oxidant and soothes compromised skin. Sorbitol Sorbitol is a sugar with hydrating properties that can nourish the probiotics that live on the skin allowing the skin microbiome to be balanced. Sorbitol breakdown by microorganisms on the skin creates beta-glucan, a skin calming antioxidant. Skin Barrier Protectors (Hydrators) Hyaluronic Acid Hyaluronic Acid is a humectant, meaning that it attracts water from the air or within the skin. Hyaluaronic Acid is one of the most common known ingredients for increasing overall moisture in skin. Vitamin C [Ascorbic Acid] Ascorbic Acid is an antioxidant and the most stable Vitamin C form. Ascorbic Acid aids in brightening the skin and aids in the production of collagen to prevent premature aging. Prebiotics Fructooligosaccharides Fructooligosaccharides is a prebiotic sugar used as food by the skin microbiota. It’s also a good source of antioxidants. It helps to keep the skin clean, hydrated, and well nutrified. It helps to maintain a healthy microbiome for your skin. Niacinamide Niacinamide is a vitamin that is water-soluble and penetrate into the skin with ease. Niacinamide aids in reducing the visibility of pores and removes dullness and restores the skin. Licorice Root Licorice Root is a plant based ingredients that can be cultivated in Asia, Europe, and in the Middle East. Licorice Root is a brightening agent in skincare products and can repair the skin. Lactic Acid Lactic Acid is a metabolic by-product released by the fermentation of microorganisms like lactobacillus. Lactic acid strengthens the skin barrier and has a positive impact on the skin microbiome balance. It also helps in reducing uneven tone and brightens skin tone.

How to Test My Microbiome at Home? How to Test My Microbiome at Home? Advancements in next-generation sequencing (NGS) have made it easier for consumers to analyse their microbiome at home, providing insights into digestion, immune function and risks for chronic conditions like obesity and inflammatory bowel disease. (Kashyap et al., 2013; Mills et al., 2019) What was once confined to research labs is now accessible to individuals through at-home testing kits. Testing your microbiome at home involves using specialised kits that analyse stool, saliva, or skin samples to provide insights into the composition of your microbiota. At-Home Microbiome Testing Walkthrough Choose a Testing Kit: Several companies offer microbiome testing kits that can be purchased online. The most common ones focus on gut bacteria via stool samples, while others may analyse saliva or skin samples. Sample Collection: The kit will come with tools to collect your sample, usually a test tube for stool, saliva, or skin swabs. Each kit typically contains instructions, a sterile collection tool, a labelled container for the sample, and a prepaid shipping label to send the sample back to the lab for analysis. Return Your Sample: After collecting the sample, you place it in the provided container, label it, and use the prepaid shipping label to return it to the lab. DNA Analysis: Once the sample reaches the lab, it undergoes DNA sequencing, usually through next-generation sequencing (NGS) techniques. This process identifies the types and quantities of bacteria and other microbes in the sample. (Franzosa et al., 2018) Results: After the analysis, the company provides a detailed report of your microbiome, including the diversity and relative abundance of microbes. Some tests may offer personalised health or dietary recommendations based on your microbiome profile. (Mills et al., 2019) Actionable Insights: Based on your results, you may be able to adjust your diet or lifestyle to improve your microbiome balance and overall health. Conclusion At-home microbiome testing relies on the use of NGS, which sequences the DNA of the microorganisms in your sample. This technology has been validated in numerous scientific studies and is widely used in microbiome research. (Turnbaugh et al., 2007) Companies typically compare your microbiome profile against large databases of microbial genomes to provide insights into how your microbiome compares to others in terms of diversity and health markers. (Human Microbiome Project Consortium, 2012) While at-home microbiome tests are an exciting development in personalised health and have become a beacon in providing valuable information, it’s important to note that the science is still evolving. The relationships between specific microbes and health conditions are not fully understood yet and more research is needed to translate these findings into actionable clinical advice (Zhernakova et al., 2016). As research into the human microbiome continues, these tests will likely become even more accurate and influential in shaping personalised health strategies. References Franzosa, E. A., McIver, L. J., Rahnavard, G., Thompson, L. R., Schirmer, M., Weingart, G., … & Huttenhower, C. (2018). Species-level functional profiling of metagenomes and metatranscriptomes. Nature Methods, 15(11), 962-968. https://doi.org/10.1038/s41592-018-0176-y Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486(7402), 207-214. https://doi.org/10.1038/nature11234 Kashyap, P. C., Marcobal, A., Ursell, L. K., Smits, S. A., Sonnenburg, E. D., Costello, E. K., ... & Sonnenburg, J. L. (2013). Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proceedings of the National Academy of Sciences, 110(42), 17059-17064. https://doi.org/10.1073/pnas.1306070110 Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(1), 51. https://doi.org/10.1186/s13073-016-0307-y Mills, S., Stanton, C., Lane, J. A., Smith, G. J., & Ross, R. P. (2019). Precision nutrition and the microbiome, part I: Current state of the science. Nutrients, 11(4), 923. https://doi.org/10.3390/nu11040923 Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., … & Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-215. https://doi.org/10.1038/nature25973 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., … & Wijmenga, C. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369

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