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How to Test My Microbiome at Home? How to Test My Microbiome at Home? Advancements in next-generation sequencing (NGS) have made it easier for consumers to analyse their microbiome at home, providing insights into digestion, immune function and risks for chronic conditions like obesity and inflammatory bowel disease. (Kashyap et al., 2013; Mills et al., 2019) What was once confined to research labs is now accessible to individuals through at-home testing kits. Testing your microbiome at home involves using specialised kits that analyse stool, saliva, or skin samples to provide insights into the composition of your microbiota. At-Home Microbiome Testing Walkthrough Choose a Testing Kit: Several companies offer microbiome testing kits that can be purchased online. The most common ones focus on gut bacteria via stool samples, while others may analyse saliva or skin samples. Sample Collection: The kit will come with tools to collect your sample, usually a test tube for stool, saliva, or skin swabs. Each kit typically contains instructions, a sterile collection tool, a labelled container for the sample, and a prepaid shipping label to send the sample back to the lab for analysis. Return Your Sample: After collecting the sample, you place it in the provided container, label it, and use the prepaid shipping label to return it to the lab. DNA Analysis: Once the sample reaches the lab, it undergoes DNA sequencing, usually through next-generation sequencing (NGS) techniques. This process identifies the types and quantities of bacteria and other microbes in the sample. (Franzosa et al., 2018) Results: After the analysis, the company provides a detailed report of your microbiome, including the diversity and relative abundance of microbes. Some tests may offer personalised health or dietary recommendations based on your microbiome profile. (Mills et al., 2019) Actionable Insights: Based on your results, you may be able to adjust your diet or lifestyle to improve your microbiome balance and overall health. Conclusion At-home microbiome testing relies on the use of NGS, which sequences the DNA of the microorganisms in your sample. This technology has been validated in numerous scientific studies and is widely used in microbiome research. (Turnbaugh et al., 2007) Companies typically compare your microbiome profile against large databases of microbial genomes to provide insights into how your microbiome compares to others in terms of diversity and health markers. (Human Microbiome Project Consortium, 2012) While at-home microbiome tests are an exciting development in personalised health and have become a beacon in providing valuable information, it’s important to note that the science is still evolving. The relationships between specific microbes and health conditions are not fully understood yet and more research is needed to translate these findings into actionable clinical advice (Zhernakova et al., 2016). As research into the human microbiome continues, these tests will likely become even more accurate and influential in shaping personalised health strategies. References Franzosa, E. A., McIver, L. J., Rahnavard, G., Thompson, L. R., Schirmer, M., Weingart, G., … & Huttenhower, C. (2018). Species-level functional profiling of metagenomes and metatranscriptomes. Nature Methods, 15(11), 962-968. https://doi.org/10.1038/s41592-018-0176-y Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486(7402), 207-214. https://doi.org/10.1038/nature11234 Kashyap, P. C., Marcobal, A., Ursell, L. K., Smits, S. A., Sonnenburg, E. D., Costello, E. K., ... & Sonnenburg, J. L. (2013). Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proceedings of the National Academy of Sciences, 110(42), 17059-17064. https://doi.org/10.1073/pnas.1306070110 Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(1), 51. https://doi.org/10.1186/s13073-016-0307-y Mills, S., Stanton, C., Lane, J. A., Smith, G. J., & Ross, R. P. (2019). Precision nutrition and the microbiome, part I: Current state of the science. Nutrients, 11(4), 923. https://doi.org/10.3390/nu11040923 Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., … & Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-215. https://doi.org/10.1038/nature25973 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., … & Wijmenga, C. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369

Certify your skincare product with us! Maximise microbiome benefits in your strategy. Let's start today for success! Skin Microbiome Testing As the skincare industry grows, consumers demand transparency from the brands formulating their products. It has become essential for formulators to create products they are willing to test to present scientifically backed data-driven evidence of their products' true effects. Sequential offers microbiome testing for your skincare formulations, ranging from moisturizers, serums, cleansers, SPF products, etc. We are dedicated to understanding how your product interacts with the skin and its microbes. Depending on how in-depth you want to go, we offer qPCR, 16S, ITS, and Shotgun Metagenomics. Download Case Study! Personalized Approach to Testing Unlike other methodologies present within the industry, Sequential's approach ensures that your product's data and analysis will stand the test of industry regulations when they are introduced. You can tailor your study entirely to your unique requirements. Test Products in a Real-Life Context The microbiome comprises a complex ecosystem of microorganisms that live together in a delicate balance, which is why it's best to test directly upon it directly. To fully understand the impact a product is having on the microbiome, in vivo is the only way. Collect Longitudinal Data With in vivo testing we can design your study around the extended use of a product over multiple time points. This allows us to review how a product is performing before and after usage, but also take into account its gradual impact on the microbiome. Measure Against a Control Group Measure a product against a control group that might have a different percentage of your active ingredient within its formulation or no active at all. This will allow for deeper insights into the impact of a formulation on microbial balance and diversity. 4 Sequencing Reports To Pick From Depending on your development stage and what you are interested in studying we offer qPCR, 16S, ITS, and Shotgun Metagenomics. With our qPCR Smart Probes™ we can go down to the strain level in our analysis. Personalize Your Microbiome Study! The body's skin surface consists of the largest organ within the human body, hosting trillions of microbes (bacteria, viruses, fungi, etc.). These microbes protect the body from external forces, playing a key role in systemic human health. Clinically Validated Collection System In addition to skin swabs, at Sequential we have developed another strong innovation to collect reliable, reproducible, and straight forward skin samples - making it that much easier to do remote consumer and clinical studies. - Validated with external parties for DNA and RNA collection, both from microbial and host cells. - Published in peer-reviewed journals, showing ease of collection and adoption for clinical studies in a range of studies. -Clinically tested on 7 unique body sites. Smart Probe s ™ Our dedicated team of scientists have developed a method of evaluating microbes through our Smart Probes™. These refer to a panel of 20 key microbes we have specifically identified as having the most impact on skin health. Over and above the taxonomic characterisation that 16S offers, which gives us a snapshot of all the genus present within a collected sample (Cutibacterium, Staphyloccocus, etc.) our targeted approach takes it a step further, opening the lens to the species (C. acnes ), sub-species (C. acnes defendens ) and even strains within them. This is a crucial distinction as not all strains of a species behave similarly. In Fact, we find that within these species there are strains associated with inflammation and strains that are commensal, and beneficial. Gold Standard Certification Sequential has developed the gold standard test for products designed to target the microbiome, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. Using next-generation sequencing of the collection of micro-organisms found on the body, before and after product usage, Sequential investigates the microbial balance and diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. We give you an in vivo certification that your product maintains the microbiome. And it’s not exclusive to skincare! We do this for haircare products, oral products, and vulva/vaginal microbiomes. Personalize Your Microbiome Study! Supplement Your Microbiome Study Recruitment Services Let us take care of the entire candidate recruitment process for you! View More Biophysical Assessments Increase your data on the use of your product by evaluating additional biophysical factors. View More Formulation Support Seek consultation advice for your formulation if you are re-formulating or developing a new product. View More FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Pioneer global in vivo microbiome certification. Redefine skin science for a distinct market edge. Elevate your brand now. Global Leader for in vivo Microbiome Certification Create a World of Healthier Microbiomes In today's competitive market, it's crucial to find a unique selling point that sets your brand apart from the crowd. By harnessing the power of skin microbiome science, investing in in vivo testing, and obtaining the gold standard certification, you can create a competitive advantage that resonates with your customers. Gold Standard Certification Sequential is the gold standard for in vivo microbiome testing, using the most advanced analysis and sequencing technology to extract real and impactful conclusions. Global Testing Platform Having developed a testing platform that transcends continents, Sequential’s certification is globally recognised by academics, professionals and brands across the world. Human Microbiome Testing Sequential relies solely on the in vivo (in or on humans) approach due to the complex nature of the microbiome. The only meaningful way to test the microbiome is in vivo . Proprietary Microbiome Panel Having created a simpler approach to testing with our qPCR Smart Probes™, Sequential is able to measure the impact of a product against 20 key microbes down to strain level. Why is Certification Crucial? At present, there are no legal requirements when it comes to products claiming microbiome benefits. This is because the industry is still a young one, finding its footing and establishing its norms. As a result, Sequential has developed an in vivo testing approach with 25 minimum participants per group study to ensure that our studies are acknowledged at the strictest academic level. Unlike the in vitro approach, our in vivo certification is designed to demonstrate the true impact of all formulations in a real-life context on accurate application sites. Certify your Product Today! Rising Consumer Demand for Microbiome Supporting Formulations At Sequential, we have carried out significant market research on the demand for products claiming microbiome benefits. The results of our market research on over 3,500 participants found that 80% demand a customised microbiome-based skincare product that factors ethnicity, age, location and skin concerns. Moreover, 65% understand that the skin microbiome provides a protective barrier on the surface of their skin, and 60% would spend more on a skincare product that can positively impact their skin microbiome. (Sequential market research in 2019: 99% women, ages 18+) FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Multi-Omic Studies with Sequential At Sequential, our mission has always been clear: to understand the impact of the microbiome on humans and how humans impact the microbiome in order to characterize human health fully. Our Multi-Omic Studies brings us back to the core of our mission by offering an unparalleled approach to skin health research. By combining human and microbial analysis, Sequential is setting a new standard in clinical testing. This comprehensive methodology enables us to unlock deeper insights into the complex interplay between the microbiome and human biology, offering more tailored and effective product assessments for our partners in personal care and the pharmaceutical industries. Start Your Multi-Omic Study Today! *Hover over the diagram to unlock each area that we explore! Identify key genetic markers linked to health, aging, and disease susceptibility Predict responsiveness to product SNP Detection & Risk Assessment Gene Expression Profile Uncover how genes are activated in response to lifestyle, environment, and treatments The effect of product on skin-related gene expression Protein Profiling Analyse protein biomarkers to track biological changes and optimise product efficacy Measure skin protein production after a product treatment Lipid Profiling Investigate lipid composition for insights into skin barrier function and metabolic health Assess how a product restores lipid homeostasis qPCR Sequencing Investigate the absolute quantification of key microbes in any sample Assess how a product impacts the most significant bacteria in a sample Metatranscriptomics Uncover how genes are activated in response to lifestyle, environment, & treatments. The effect of product on skin-related microbial gene expression ITS Sequencing Investigate all present fungi in any given sample Understand how a product impacts the skin's fungal community Shotgun Metagenomics Investigate all present microorganisms in any given sample Understand how a product impacts the skin's bacteria, fungal and viral communities 16S Sequencing Investigate all present bacteria in any given sample Understand how a product impacts the skin's bacterial community Metabolomics Map metabolic pathways to assess skin and body health, aging, and personalized wellness. Metabolic shift pre- and post-product application Why Multi-Omic Testing? Understanding how products impact both the human body and its microbiome is essential for creating truly effective solutions. Our multi-omic approach provides: Deeper Insights – See how products influence human health at a biological level Clinically Validated Science – Data-backed results to support claims and innovation Personalized Health & Wellness – Create tailored products that optimize skin and body health Scalable & Flexible Testing – In-lab or remote studies with diverse sample collection options Microbiome's Impact on Human Health The Bright Side of Skincare: How LEDs Influence Microbial Balance With LED face masks and light-based skincare rapidly increasing in popularity, light has become a new frontier in skin health. Previously seen as a threat and something that we needed to block or avoid, light is now being seen as therapeutic tool. Yet beyond the visible changes to tone and texture, light also interacts with the skin microbiome. Understanding how different wavelengths influence this ecosystem is key to ensuring that light enhances, rather than harms, our skin’ How Pregnancy and Postpartum Transform the Skin Microbiome During pregnancy, the skin microbiome undergoes significant shifts. Across the trimesters, both the composition and behaviour of skin bacteria change. Postpartum, the maternal skin microbiome continues to evolve which is influenced by hormonal resets, environmental exposures, and hygiene practices. These shifts can also influence an infant’s earliest microbial encounters, during a critical period of skin development. What We Know: Pregnancy significantly changes the skin mic Understanding the Microbial Roots of Seborrheic Dermatitis Seborrheic dermatitis (SD) is a common inflammatory skin condition primarily affecting the scalp, face and chest. It appears as red, flaky, greasy patches or plaques and can cause itching and discomfort. It is a non-contagious condition varying in severity, from mild dandruff to persistent inflamed lesions. What we know: SD is linked to three main factors: increased sebum (oil) production, colonization by Malassezia yeast, and an abnormal immune response. Genetics, skin barr Your Muti-Omics Questions Answered What is multi-omic testing, and why is it important? Multi-omic testing integrates multiple layers of biological data—including genomics, metabolomics, proteomics, and microbiome science—to provide a more comprehensive understanding of how products impact both the human body and its microbiome. This approach goes beyond traditional microbiome testing, helping brands develop more effective, scientifically backed solutions. How does Sequential’s multi-omic approach differ from traditional microbiome testing? Most microbiome studies focus only on bacterial composition. At Sequential, we go further by analyzing: • Human gene expression to understand how a product influences skin health at the molecular level • Metabolomics & lipid profiling to track changes in skin health and barrier function • Protein profiling to measure product-driven biological changes • Advanced microbiome techniques to assess bacteria, fungi, and viruses collectively This holistic approach ensures deeper insights for product development and claim validation. What can multi-omic testing help me understand about my product? • Product effectiveness – See how formulations impact skin and microbiome health • Personalized wellness – Identify genetic or metabolic factors that influence individual responses to products • Barrier function & hydration – Understand how products restore lipid balance and improve the skin barrier • Microbial balance – Determine whether a product supports a healthy microbiome or disrupts it What specific tests does Sequential offer under multi-omic analysis? Human Health Insights • SNP Detection & Risk Assessment – Identifies genetic markers related to aging, disease risk, and product responsiveness • Metabolomics – Maps metabolic pathways to track skin and body health before and after product use • Human Gene Expression – Determines how genes react to lifestyle, environmental factors, and treatments • Protein Profiling – Measures skin protein production to optimize product efficacy • Lipid Profiling – Assesses lipid composition for insights into skin barrier health Microbiome Science & Testing • Smart Probes™ qPCR – Tracks 20 key microbes to measure microbiome shifts after product use • Microbial Profiling (16S & ITS) – Identifies all bacteria and fungi in a sample • Microbial Gene Expression (Metatranscriptomics) – Evaluates how microbes react to environmental factors and treatments • Shotgun Metagenomics – Provides a complete profile of bacteria, fungi, and viruses in any sample

< Back Marketing Associate Cambridge, UK Job Type Full-time Workspace Hybrid About the Role As a Marketing Associate at Sequential, you will play a critical role in shaping our brand, product (s) and ensuring our scientific expertise is communicated to the personal care and dermo-cosmetics industries. You will support the execution of marketing strategies that drive awareness, engagement and lead generation efforts to amplify Sequential’s footprint and contribute to commercial growth. Working closely with the Head of Marketing and cross-functional teams, you’ll help bring Sequential’s unique value proposition to life across digital channels, campaigns and tradeshows (+ conferences). This is an exciting opportunity for a creative, detail-oriented marketer to gain hands-on experience in a fast-growing biotech company at the forefront of microbiome and human biomarker testing innovation. An ideal candidate should have the drive to quickly learn our scientific offering to be able to translate them into strong marketable assets. We are looking for someone who will hit the ground running and be able to integrate into the team seamlessly. 3-6 months into the role, we expect a concrete understanding of our offerings, the ability to support in marketing efforts, and have ownership of individual duties and tasks to ensure smooth execution of overarching marketing strategies. Our end clients are B2B companies who operate in both personal care and pharma industries. Both these target groups require different marketing tactics to reach. In order to succeed within this role, a deep understanding of these industries, their pain points and objections will be critical. Essential Duties and Responsibilities: ●Marketing Campaign Support: Assist in the execution of marketing campaigns across digital, email, and content channels to support business and sales objectives. ●Content Development: Help create and coordinate marketing materials including website content, blog posts, email newsletters, social media content, presentations, and sales enablement assets. ●Brand and Messaging Alignment: Ensure all marketing materials are consistent with Sequential’s brand voice, positioning, and scientific credibility. ●Market and Customer Research: Support in conducting research on industry trends, customer needs, and competitor activity to inform marketing strategies and messaging. ●Digital Marketing & Analytics: Support website updates, email campaigns, and social media efforts; track performance metrics and assist in reporting insights. ●Support with Ads Strategies: Support with Google Ads and LinkedIn Ads to increase website traffic and lead generation form submissions. ●Cross-Functional Collaboration: Work closely with sales, product, and operations teams to ensure marketing initiatives align with commercial goals and customer needs. ●Product and Scientific Knowledge: Develop a strong understanding of Sequential’s offerings and the microbiome and human biomarker landscape to effectively communicate value to target audiences. Qualifications and Experience: ●1–2 years of experience in marketing, communications, or a related role; experience in biotechnology, life sciences, or cosmetics is preferred. ●Working knowledge of Canva for brand-aligned digital content creation is essential. ●Quick to learn scientific concepts as a large part of the role consists of taking complicated science and translating it into tangible benefits for the industry. ●Familiarity with digital marketing tools LinkedIn, Google Ads & Analytics, Hubspot, Wix & Meta Ads is preferred. ●Excellent written and verbal communication skills with an eye for detail and storytelling. ●Creative mindset paired with analytical thinking and comfortable thinking out of the box and owning small projects. ●Bachelor’s degree in Marketing & Communications (or equivalent) with a strong interest in the pharma, dermo-cosmetics, personal care industry. ●Highly organized self-starter with the ability to work on multiple projects in a fast-paced environment. ●Collaborative, adaptable, and eager to learn in a growing company. What You Get from Us: • A competitive base salary with opportunities for growth as the company scales. • Access to our Equity Incentive Plan, allowing you to grow alongside Sequential. • Hands-on experience working with industry experts in a rapidly expanding biotech sector. • The opportunity to help shape the brand of a company advancing microbiome science and its real-world applications. About the Company Sequential is an established global leader in clinical product testing for the personal care and dermo-cosmetics industries. Formed by a team of PhD experts in genetics, epigenetics, and microbiome research, the company specializes in microbiome and human biomarker testing to champion topical products’ impacts in real use cases across skin scalp, oral and vulvovaginal formulations. The company is an Innovate UK and Enterprise Singapore-backed company, with labs in Cambridge, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 50,000 human skin microbiome samples and corresponding formulations tested clinically. With this vast genomic dataset, Sequential is figuring out optimal formulations that could potentially alleviate skin conditions, such as for acne, atopic dermatitis and rosacea. The company has been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $5MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology. Apply Now

< Back Laboratory Technician Cambridge, UK Job Type Full-time Workspace On-Site About the Role Company Description Sequential advances health and personal care research by conducting in-depth human molecular clinical testing, biomarker discovery, including skin, scalp, oral, and vaginal health. Through a comprehensive in-house platform, Sequential transforms complex biological data into actionable insights. By leveraging microbial and molecular analyses, along with a robust database of samples, ingredients, and participants globally, Sequential drives data-driven innovation and product validation. The company sets a high standard for creating effective, credible, and scientifically validated products for personal care and pharmaceutical industries. Job Title: Laboratory Technician Location: Cambridge UK Job Type: Full-time Salary: £26,000-£35,000 (dependent on experience) Reports to: Laboratory Manager / Senior Scientist Role Overview We are seeking a highly motivated Laboratory Technician to support routine laboratory operations within a fast-paced production environment. The successful candidate will perform molecular testing to a high standard, ensuring compliance with company quality systems and UK laboratory best practice standards. Key Duties & Responsibilities Test samples aseptically, accurately, and within allowable time and temperature holding requirements. Perform DNA/RNA-based assays including DNA/RNA extraction, PCR, and qPCR in accordance with validated protocols. Prepare, assemble, and ship sample collection kits for clients. Support general laboratory functions, including housekeeping of the lab and equipment to maintain a contamination-free environment and preparation of reagents and consumables. Maintain Good Laboratory Practice (GLP) at all times. Operate in strict accordance with company quality and procedural manuals, ensuring compliance with all relevant accreditations and regulatory standards. Maintain laboratory facilities and equipment in good physical condition, reporting faults or deviations promptly. Contribute to a positive, professional, and safe working environment, adhering to all company health and safety policies. Participate in continuous improvement initiatives to enhance laboratory efficiency, quality, and compliance. Qualifications A science-related qualification (e.g., BSc, MSc, or equivalent), preferably in Molecular Biology, Microbiology, Biomedical Science, or a related field; Experience Practical experience performing DNA/RNA-based techniques, including DNA/RNA extraction, PCR, and qPCR. Knowledge of basic microbiological handling techniques is highly desirable. Experience working within a quality-controlled or accredited laboratory environment (e.g., ISO, UKAS, GLP) is advantageous. Skills & Attributes Strong aseptic technique and contamination control practices are essential. Excellent time management skills, with the ability to work efficiently in a high-throughput production environment. Ability to work independently without close supervision while maintaining accuracy and consistency. High level of integrity and commitment to maintaining quality standards. Proactive, adaptable, and willing to learn with a positive “can-do” attitude. Able to take initiative and act responsibly within a team environment. Clear and effective communicator, able to collaborate across multiple teams. About the Company Sequential is an established global leader in clinical product testing for the personal care and dermo-cosmetics industries. Formed by a team of PhD experts in genetics, epigenetics, and microbiome research, the company specializes in microbiome and human biomarker testing to champion topical products’ impacts in real use cases across skin scalp, oral and vulvovaginal formulations. The company is an Innovate UK and Enterprise Singapore-backed company, with labs in Cambridge, New York City and Singapore. Apply Now

Discover the power of combining microbiome testing and clinical data. Elevate your understanding with our comprehensive Clinical Assessments. Clinical Assessments for More In-Depth Analysis When it comes to testing your personal care products, we offer add-ons to supplement your microbiome research efforts and facilitate your testing experience. It has become clear in recent years that differentiation is key when creating a formulation for the competitive market, however, differentiation can be incredibly straightforward when backed with the data and scientific evidence to support it. Not only will you differentiate your brand, you will also demonstrate your commitment to providing leading-edge and effective solutions for your customers’ personal care and skincare needs. Start Your Biophysical Study Today! The only way to understand how a product performs is by putting it to the test Hydration Measurement (Corneometry and TEWL) Gain a comprehensive understanding of your product's impact on moisture retention, skin hydration and overall skin barrier function. This data can guide the development of effective moisturizing formulations. Perception Questionnaire Uncovering how users experience and interact with products. These surveys offer valuable insights into subjective factors like texture, scent, and overall satisfaction ensuring that your scientific data is enriched. Elasticity Measurement (Elastometer) Unravel the effect your product has on the skin’s elasticity through the use of elastometers, allowing you to position your product within a firming category with demonstrated benefits for graceful aging. High-Resolution Imaging Use before and after images to provide visual evidence of a product’s impact on the skin’s appearance. These tangible comparisons offer brands the ability to objectively assess changes in the skin. Dermatologist Assessment Measure and quantify inflammatory disease, atopic dermatitis (through SCORAD), psoriasis (through PASI), comedogenicity, and other hallmarks of skin conditions, by our board-certified and in-house dermatologists. Skin pH Measurement Maintain the delicate balance of the skin's acid mantle with your product by measuring pH to ensure compatibility and minimise the risk of irritation for a gentle, biome supporting formulation. FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

How do you Formulate Skincare Products? How do you Formulate Skincare Products? Formulating skincare products is a process that combines different ingredients to provide targeted skin benefits. The type of product being used, the particular skin concern and the formulation's stability and effectiveness are some of the variables that can affect the formulation process. Key Components of Skincare Formulation: Choosing the right ingredients when formulating skincare products is important, as it determines the product's effectiveness. Moreover, the chemical composition of the ingredients and their concentrations in a formulation is as important as establishing its overall effect on our health. Most skincare products typically include 15 to 20 ingredients in their formulation (Goyal & Jerold, 2023). Water Ultra-pure distilled water serves as the foundation for nearly every cosmetic formulation, including creams, lotions, makeup, deodorants, shampoos, and conditioners. It functions primarily as a solvent, helping to emulsify ingredients and ensure a smooth and consistent texture in the final product (Goyal & Jerold, 2023). Emulsifiers Promotes the formation of a homogenous and consistent texture in the formulation by encouraging the suspension of water and oil (Goyal & Jerold, 2023). Humectants Humectants are crucial for the skin's hydration balance, moisture retention, and desiccation prevention. Multiple hydroxyl, carboxyl, or other polar groups found in humectants have the ability to create hydrogen bonds with water molecules, which allows them to absorb and hold onto moisture (Du et al., 2024). Thickeners Long carbon chains and polar groups like hydroxyl, carboxyl, and amide groups make up most of the thickeners. Within solutions, these long-chain structures increase the viscosity of the solution by increasing its resistance to flow (Du et al., 2024). Preservatives Preservatives are added to prevent the growth of pathogenic and non-pathogenic microorganisms that could degrade the product or negatively impact the consumer's health De et al., 2017). Active Ingredients Ingredients that offer therapeutic advantages and improve the efficacy of skincare products, such as hyaluronic acid, are used as active components in formulations (Morganti et al., 2023). Therefore, selecting the appropriate active ingredient is crucial to creating a high-quality skin care product (Calixto & Maia, 2017). Stability testing and sensory analysis The formulations afterwards need to be tested for their stability at different temperatures and for sensory evaluation such as spreadability, cohesiveness, consistency, firmness and viscosity (Calixto & Maia, 2017). Targeting the microbiome with Skincare products Our skin is home to millions of microbial species called the Skin microbiome. A balance of all these microbes is crucial to obtain healthy skin. Imbalances cause several skin problems such as acne, rosacea…etc. So when formulating skincare products it is important to investigate each ingredient's impact on the skin microbiome. Conclusion It is of great importance to carefully consider the ingredients that are put into skincare formulations whilst considering the skin microbiome. Developing safe and efficient products is frequently the main goal, there is also a growing tendency towards customisation based on the demands of each individual's skin. This trend towards customised skincare highlights the value of customised solutions in the beauty industry and represents a deeper awareness of the various needs of various skin types and conditions. References Calixto LS, Maia Campos PMBG. Physical-Mechanical characterization of cosmetic formulations and correlation between instrumental measurements and sensorial properties. Int J Cosmet Sci. 2017 Oct;39(5):527-534. doi: 10.1111/ics.12406. Epub 2017 Jul 24. PMID: 28555924. De Groot, A. C., & White, I. R. (2001). Cosmetics and Skin Care Products. Textbook of Contact Dermatitis, 661–685.doi:10.1007/978-3-662-10302-9_32 Du XN, He Y, Chen YW, Liu Q, Sun L, Sun HM, Wu XF, Lu Y. Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology. Molecules. 2024 Jan 15;29(2):411. doi: 10.3390/molecules29020411. PMID: 38257324; PMCID: PMC10818968. Goyal N, Jerold F. Biocosmetics: technological advances and future outlook. Environ Sci Pollut Res Int. 2023 Feb;30(10):25148-25169. doi: 10.1007/s11356-021-17567-3. Epub 2021 Nov 25. PMID: 34825334; PMCID: PMC8616574. Morganti, P.; Lohani, A.; Gagliardini, A.; Morganti, G.; Coltelli, M.-B. Active Ingredients and Carriers in Nutritional Eco-Cosmetics. Compounds 2023, 3, 122-141. https://doi.org/10.3390/compounds3010011

Sequential Skin has developed the Skin Microbiome Test Kit to discover the state of skin microbiomes. You can do Skin Health Check to find what your skin needs. Sequential Skin has developed the first of its kind skin health test to discover the state of individuals' skin microbiome. People can now deep dive into their Skin Profile to figure out what their skin needs. Test your skin microbiome Benefits of your Skin Profile Skin Health Understand the state of your skin through your Skin Microbiome Balance Index score Skin Traits Learn about your skin traits through our in-app quiz and solutions for healthier skin Skin Age Discover your skin age and whether or not your skin is older/younger than you are Environment Unearth how your physical environment is impacting your skin microbiome Sample Register your kit: Register your kit on our Skin Health Tracker mobile app and answer the in-app quiz. Our Testing Technology Our microbiome test is the most comprehensive test on the market. We use a method known as quantitative real-time PCR (qPCR) that looks at specific markers in your skin microbiome and how they impact your skin. Skin Health Testing Kit Partner with Sequential Skin to bring our innovative skin health test to your customers. Give them an in-depth analysis of what lies on the surface of their skin and how best to increase its overall wellbeing. Register your Interest Frequently Asked Questions How is the sample collected? We recommend taking the test first thing in the morning, before you shower or wash your face, so the patch captures a sample when your skin is in its most natural state. Simply stick the Sequential patch on your forehead (adhesive side down) for 10 seconds and then put it in the test tube provided, and mail it back to us. More thorough instructions are included in the test kit. How long does it take to receive results? Results are received within 2-3 weeks. Where are the results received? Your skin microbiome test results can be accessed through the Skin Health Tracker mobile application. What will the report tell you? Your Sequential report gives you a clear and in-depth look at your Skin Microbiome Balance, which reflects the state of your skin microbiome and assesses the effects that your physical environment has on your skin. It will also highlight the age of your skin based on the test. How do you manage the heterogeneity within samples? “heterogeneity” comes in two forms - biological (people have different skin microbiome) and technical (experimental/sample collection/processing), the above points are addressing both Summarised more concisely here: 1. Targeted Demographics: We work closely with clients to clearly define the target demographic and skin type. 2. Strict Criteria: Inclusion and exclusion criteria minimize variability caused by treatments (e.g., antibiotics) or environmental differences (e.g., travel). 3. Smart Probes: These evaluate absolute levels of microbes on the skin, enabling us to measure exact quantities, track changes over time, and identify trends across clinical samples. 4. Synthetic Controls: Spike-in synthetic DNA controls manage variability during sample processing. 5. Standardized Protocols: Consistent, validated protocols are used across all labs, and we handle DNA extraction and qPCR in-house to ensure reliability. 6. Reproducible Sampling: Our skin patch collects samples from a consistent surface area for accurate and reproducible microbiome analysis. Biological variability: 1. Targeted Demographics: We work closely with clients to clearly define the target demographic and skin type. 2. Strict Criteria: Inclusion and exclusion criteria minimize variability caused by treatments (e.g., antibiotics) or environmental differences (e.g., travel). Technical variability: 1. Smart Probes: These evaluate absolute levels of microbes on the skin, enabling us to measure exact quantities, track changes over time, and identify trends across clinical samples. 2. Synthetic Controls: Spike-in synthetic DNA controls manage variability during sample processing. 3. Standardized Protocols: Consistent, validated protocols are used across all labs, and we handle DNA extraction and qPCR in-house to ensure reliability. 4. Reproducible Sampling: Our skin patch collects samples from a consistent surface area for accurate and reproducible microbiome analysis.

What is a Microbiome Formulation? What is a Microbiome Formulation? Less is More approach Statistically, Women typically apply around 16 beauty products each day, exposing their skin to about 515 synthetic chemicals daily. (“The Average Woman Uses 16 Beauty Products Every Day. Here Are the Ones Worth the Investment,” 2018) This extensive exposure has led to a rise in skin sensitivity, which now affects 60-70% of women and 50-60% of men worldwide (Sensitive skins wear their own skin microbiota, 2024) - a number that continues to climb. To mitigate these effects, experts advise using fewer, essential ingredients and prioritising simple, balanced formulations over emphasising single "hero" ingredients. This holistic approach fosters skin compatibility, supporting healthier skin with reduced risk of irritation. Traditional vs Microbiome approach The traditional skin care approach highlights a single, "hero" ingredient or a blend of active ingredients to deliver specific benefits, with the spotlight on these components as the main drivers of product efficacy. However, a microbiome-focused approach takes a broader, more holistic perspective. It considers how each ingredient, including non-active additives (functional ingredients), interacts with the skin and its microbiome. This method aims to create formulations that support the skin's natural microbial balance, ensuring that every component contributes positively to overall skin health. Anhydrous Products Anhydrous products, with no water, do not require preservatives since bacteria need moisture to grow. However, they face challenges: incorporating water-soluble actives is difficult, and they are more prone to oxidation and rancidity. Their thick, oil-based consistency may also not suit all skin types, especially oily or sensitive skin. Despite these drawbacks, anhydrous formulations appeal to consumers interested in preservative-free, minimal skincare. Water-based Products Water in skincare products often makes up 80%, requiring emulsifiers to mix with oils and preservatives to prevent bacterial and fungal growth. To avoid contamination, effective preservation is essential. Instead of skipping preservation, reducing water activity can enhance product stability by limiting moisture, which is crucial for safer, less chemically intensive formulations. pH Maintaining a skincare formulation with a slightly acidic pH, ideally below 5, supports the skin's microbiome and barrier function. Alkaline cleansers with pH levels above 7 can disrupt the acid mantle, weakening the barrier and encouraging harmful bacteria. Hülpüsch et al. (2022) found that a higher skin pH (5.7–6.2) in atopic dermatitis patients is linked to increased Staphylococcus aureus colonisation, worsening inflammation and barrier issues. Acidic formulations may help control bacterial overgrowth, reducing flare-ups and promoting skin health in at-risk groups like those with AD. Ingredients Formulations that are high in lipids can strengthen the skin barrier, enhancing hydration and resilience against irritants. Combining gentle surfactants with super fatty agents further reduces potential for irritation and maintains moisture, which is particularly beneficial for sensitive skin types. These principles help prevent disruption of the microbiome, ensuring the skin remains balanced and resilient over time (Van Belkum et al., 2023). The selection of mildly acidic, pH-balanced ingredients close to the skin’s natural acidity (4.7 < pH < 5.7) is crucial, as it helps preserve the skin’s barrier and microbiome. Preservatives To protect the skin microbiome and reduce bacterial growth, it’s essential to minimise preservatives, especially in oil-based products. Anhydrous formulations, which don’t require preservatives, are ideal when possible. For water-based products, alternatives such as antimicrobial peptides (AMPs), and natural humectants like glycerin, sodium lactate, and NMF components (ceramide, urea), can improve microbial stability and skin barrier function (Halla et al., 2018). Airless packaging and sterilisation methods like UHT technology can further enhance product safety by minimising contamination, reducing the need for traditional preservatives. Surfactants Water-in-oil System: Choose emulsifiers with a low hydrophilic-lipophilic balance ratio and natural ingredients like plant oils or sugars. Limit emulsifier concentration to maintain skin barrier integrity. Avoid Polysorbate 80, which can promote pathogen growth, and use alternatives like Polyglyceryl 4 Oleate, which self-emulsify when mixed with water. Oil-in-water System: Use microbiome-friendly emulsifiers derived from natural sources like plant oils and sugars. Examples include Olivem 1000, made from olive oil (Cetearyl Olivate and Sorbitan Olivate), and Emulium Mellifera MB, which combines beeswax and jojoba wax (Polyglyceryl-6 Distearate and Jojoba Esters). These emulsifiers help maintain skin health while supporting the microbiome. It's also important to limit the concentration of emulsifiers to avoid disrupting the skin barrier. Fragrances/Essential Oils Fragrances should generally be avoided in skincare formulations, especially for sensitive skin, as many fragrances can cause irritation. However, certain essential oils may serve as antimicrobial agents in products for non-sensitive skin, offering a natural alternative to synthetic preservatives. For instance, bergamot and lavender oils demonstrate antibacterial and antifungal effects, particularly against Staphylococcus aureus, though they do not affect S. epidermidis (Kim et al., 2022). Additionally, rosemary oil and phenylethyl alcohol show strong antifungal properties, adding preservative benefits without traditional preservatives. Reference Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143-155. Halla, N., Fernandes, I. P., Heleno, S. A., Costa, P., Boucherit-Otmani, Z., Boucherit, K., Rodrigues, A. E., Ferreira, I. C. F. R., & Barreiro, M. F. (2018). Cosmetics Preservation: A Review on Present Strategies. Molecules, 23(7), 1571. https://doi.org/10.3390/molecules23071571 The average woman uses 16 beauty products every day. Here are the ones worth the investment. (2018, December 6). The Telegraph. https://www.telegraph.co.uk/beauty/face/essential-skincare-makeup-products-use-everyday/ Sensitive skins wear their own skin microbiota - BEAUTY HORIZONS 1 2021 WW. (2024, March 27). https://digital.teknoscienze.com/beauty_horizons_1_2021_ww/sensitive_skins_wear_their_own_skin_microbiota Hülpüsch, C., Tremmel, K., Hammel, G., Bhattacharyya, M., De Tomassi, A., Nussbaumer, T., Neumann, A. U., Reiger, M., & Traidl‐Hoffmann, C. (2020). Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity. Allergy, 75(11), 2888–2898. https://doi.org/10.1111/all.14461 Van Belkum, A., Lisotto, P., Pirovano, W., Mongiat, S., Zorgani, A., Gempeler, M., Bongoni, R., & Klaassens, E. (2023). Being friendly to the skin microbiome: Experimental assessment. Frontiers in Microbiomes, 1. https://doi.org/10.3389/frmbi.2022.1077151 Nielsen, H. L., et al. (2016). Influence of emulsifiers on microbial stability in cosmetic formulations. International Journal of Cosmetic Science, 38(4), 357-366. https://doi.org/10.1111/ics.12301 Kim, J., et al. (2022). Antimicrobial effects of essential oils on skin microbiota. Journal of Cosmetic Science, 73(5), 452-460.

< Back Sales Associate (NYC Based) New York, NY, USA Job Type Full-time Workspace Hybrid About the Role As a Sales Associate at Sequential, you will be essential in building relationships and expanding our reach within the personal care and dermocosmetic industry. Your role will involve supporting business development efforts, assisting in sales strategy execution, and helping grow market share for Sequential’s innovative products and services. You will work closely with the Commercial Director and team to meet sales goals, develop client relationships, and contribute to Sequential’s mission of advancing microbiome science. This is a fantastic opportunity for an ambitious sales professional to gain hands-on experience and make a tangible impact in a rapidly growing biotech field. Essential Duties and Responsibilities: Sales Support and Development: Assist in the identification and acquisition of new customer accounts, supporting the growth of Sequential’s client base. Client Relationship Building: Cultivate relationships with existing and prospective clients, focusing on understanding their needs and promoting Sequential’s unique offerings. Market Research: Conduct ongoing research to stay informed on industry trends and competitor activity, providing valuable insights for sales strategies. CRM and Data Management: Maintain accurate records in our CRM (HubSpot), tracking interactions, progress, and key performance indicators. Sales Target Achievement: Work towards defined sales goals, contributing to Sequential’s revenue targets and growth ambitions. Collaborative Efforts: Work closely with marketing, product, and operations teams to align efforts and ensure a seamless customer experience. Product Knowledge Development: Stay up-to-date on Sequential’s product offerings and the latest microbiome research to effectively communicate value to clients. Qualifications and Experience: 1-2 years of sales experience, ideally within the biotechnology, cosmetics, or life sciences fields. Familiarity with CRM systems, preferably HubSpot, and the ability to manage data with accuracy. Strong written and verbal communication skills with a passion for client interaction and customer service. Tech-savvy and eager to leverage technology to enhance sales effectiveness. Bachelor's degree in Life Sciences, Business, or a related field preferred; demonstrated interest in microbiome or biotechnology is a plus. Motivated self-starter with a goal-oriented mindset and excellent organizational skills. Ability to work collaboratively and adapt in a dynamic, fast-paced environment. What You Get from Us: A base salary with a commission structure that rewards your hard work and success. Access to our Equity Incentive Plan, allowing you to grow alongside Sequential as we expand. The chance to work with industry experts in one of the fastest-growing sectors within biotechnology. Be part of a company at the forefront of microbiome research, making an impact in the personal care and dermocosmetic fields. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $5MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now