top of page

Multi-Omic Studies with Sequential

At Sequential, our mission has always been clear: to understand the impact of the microbiome on humans and how humans impact the microbiome in order to characterize human health fully. Our Multi-Omic Studies brings us back to the core of our mission by offering an unparalleled approach to skin health research.
 

By combining human and microbial analysis, Sequential is setting a new standard in clinical testing. This comprehensive methodology enables us to unlock deeper insights into the complex interplay between the microbiome and human biology, offering more tailored and effective product assessments for our partners in personal care and the pharmaceutical industries.

Human (9).png

*Hover over the diagram to unlock each area that we explore!

Human (11).png
SNP.png

Identify key genetic markers linked to health, aging, and disease susceptibility

Predict responsiveness to product  

SNP Detection & Risk Assessment

​

Gene Expression Profile

Human Gene Expression.png

Uncover how genes are activated in response to lifestyle, environment, and treatments

The effect of product on skin-related gene expression

Protein Profiling

Multi-omics Diagrams (6).png

 Analyse protein biomarkers to track biological changes and optimise product efficacy

Measure skin protein production after a product treatment

Lipid Profiling

Lipids.png

Investigate lipid composition for insights into skin barrier function and metabolic health

Assess how a product restores lipid homeostasis

qPCR Sequencing

qpcr.png

Investigate the absolute quantification of key microbes in any sample 

Assess how a product impacts the most significant bacteria in a sample

Metatranscriptomics

Multi-omics Diagrams (10).png

Uncover how genes are activated in response to lifestyle, environment, & treatments.

The effect of product on skin-related microbial gene expression

ITS Sequencing

ITS.png

Investigate all present fungi in any given sample 

Understand how a product impacts the skin's fungal community

Shotgun Metagenomics

Shotgun.png

Investigate all present microorganisms in any given sample 

Understand how a product impacts the skin's bacteria, fungal and viral communities

16S Sequencing

16S.png

Investigate all present bacteria in any given sample 

Understand how a product impacts the skin's bacterial community

Metabolomics

Metabolomics.png

Map metabolic pathways to assess skin and body health, aging, and personalized wellness.

Metabolic shift pre- and post-product application 

Human (7).png

Why Multi-Omic Testing?

Understanding how products impact both the human body and its microbiome is essential for creating truly effective solutions. Our multi-omic approach provides:

​

  • Deeper Insights – See how products influence human health at a biological level

​

  • Clinically Validated Science – Data-backed results to support claims and innovation

​

  • Personalized Health & Wellness – Create tailored products that optimize skin and body health

​

  • Scalable & Flexible Testing – In-lab or remote studies with diverse sample collection options

Microbiome's Impact on Human Health

Human (6).png
Sequential Lab.jpg

Your Muti-Omics Questions Answered

  • What is Sequential's testing platform?
    Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs.
  • Why is it necessary to test the microbiome in vivo?
    At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data.
  • What type of sequencing technology does Sequential use for analysis?
    We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome.
  • Does Sequential offer claims certification for tested products?
    We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.
bottom of page