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With LED face masks and light-based skincare rapidly increasing in popularity, light has become a new frontier in skin health. Previously seen as a threat and something that we needed to block or avoid, light is now being seen as therapeutic tool. Yet beyond the visible changes to tone and texture, light also interacts with the skin microbiome. Understanding how different wavelengths influence this ecosystem is key to ensuring that light enhances, rather than harms, our skin’s microbial balance. What we know: Each wavelength of light interacts differently with both skin cells and the microbes that live on them. Of the wavelengths, red and blue have been found to have the best therapeutic benefits. Blue light (400–470 nm) has been shown to target bacteria like Cutibacterium acnes and Staphylococcus aureus , species commonly linked to acne and inflammation. By interacting with microbial chromophores, it produces reactive oxygen species that damage bacterial membranes. This can help rebalance the microbiome when used at the right dose (Plattfaut et al., 2021). Red light (620–750 nm), has been shown to have anti-inflammatory and tissue-repair properties. It’s widely used in photobiomodulation therapy and research suggests that red light can enhance wound healing and reduce bacterial load when paired with blue light (Lee  et al , 2007). Together, these wavelengths demonstrate that light can influence microbial composition and function, not just skin appearance. But precision matters: the wrong dose or wavelength could just as easily disrupt the skin microbiome. Industry Impact and Potential As light-based therapies and tools move from specialist clinic to home use, understanding their microbiome impact becomes essential. The skin microbiome is now a critical factor in dermatological science and, consumer skincare innovation must consider the impact in respect to the microbiome. Emerging research hints at the potential of personalised phototherapy tuned to an individual’s microbiome composition. Microbiome-safe LED protocols that support healthy microbial diversity. Combinations of blue and red light that offer both microbial control and skin repair. These developments can help us redefine how we think about light, as a precision tool for microbial balance. Our solution: Sequential is at the forefront of microbiome product testing and development, providing tailored solutions to understand how environmental factors, such as light, influence the skin microbiome. Using advanced research techniques and supported with a database o f over 50,000 human samples, Sequential offers comprehensive services to evaluate product impacts and formulations on the skin microbiome.   Our goal is to provide science-driven insights that help brands design light-based treatments and formulations that work with the microbiome, not against it. References: Lee, S., You, C., & Park, M., 2007. Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV.  Lasers in Surgery and Medicine , 39. https://doi.org/10.1002/LSM.20412 . Plattfaut, I., Demir, E., Fuchs, P., Schiefer, J., Stürmer, E., Brüning, A., & Opländer, C., 2021. Characterization of Blue Light Treatment for Infected Wounds: Antibacterial Efficacy of 420, 455, and 480 nm Light-Emitting Diode Arrays Against Common Skin Pathogens Versus Blue Light- Induced Skin Cell Toxicity.  Photobiomodulation, photomedicine, and laser surgery , 39 5, pp. 339-348.

During pregnancy, the skin microbiome undergoes significant shifts.  Across the trimesters, both the composition and behaviour of skin bacteria change. Postpartum, the maternal skin microbiome continues to evolve which is influenced by hormonal resets, environmental exposures, and hygiene practices. These shifts can also influence an infant’s earliest microbial encounters, during a critical period of skin development. What We Know: Pregnancy significantly changes the skin microbiota with key bacteria diminishing in the first trimester (Radocchia et al,  2024).  Progressing through the trimesters, the microbiome becomes simpler as highly connected species decline, reducing microbial resilience (Mesa et al, 2020). This impacts the skin’s barrier function, making the skin more susceptible to dryness, irritation, and inflammation (Radocchia et al,  2024). Maternal microbiome changes during pregnancy and postpartum can influence infant skin health and early dermatological risk (Mutic et al,  2017).   Industry Impact and Potential Pregnancy and postpartum present an innovative opportunity for microbiome-focused skincare. Barrier-focused care for sensitive and reactive skin: As microbial networks decline in complexity, barrier function becomes more vulnerable. pH-balanced systems, ceramides, and gentle formulations can help maintain stability. Probiotic and prebiotic skincare: Targeted probiotic or prebiotic formulations can help restore microbial diversity, reduce inflammation, and strengthen skin resilience. Education and transparency:  Clear labelling (e.g., “microbiome-safe,” “pregnancy-safe”) and guidance on supportive vs. avoidable ingredients empower informed decision-making. Our Solution At Sequential, we connect advanced microbiome science with real-world product innovation to support maternal skin health during pregnancy and postpartum. We apply advanced microbiome profiling and multi-omic analysis to help brands understand how pregnancy and postpartum affect skin microbial balance. With a global database of 50,000+ samples and customised testing platforms, we assess whether formulations are microbiome-safe, gentle for pregnancy, and supportive of beneficial bacteria. Through targeted studies and formulation guidance, we enable science-backed products that protect maternal skin. References : Mesa, M. et al. (2020). The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review. Nutrients, 12.  https://doi.org/10.3390/nu12010133 Mutic, A. et al. (2017). The Postpartum Maternal and Newborn Microbiomes.  MCN: The American Journal of Maternal/Child Nursing, 42, 326–331. https://doi.org/10.1097/nmc.0000000000000374 Radocchia, G. et al. (2024). Women Skin Microbiota Modifications during Pregnancy.  Microorganisms, 12(4), 808. https://doi.org/10.3390/microorganisms12040808

Seborrheic dermatitis (SD) is a common inflammatory skin condition primarily affecting the scalp, face and chest. It appears as red, flaky, greasy patches or plaques and can cause itching and discomfort. It is a non-contagious condition varying in severity, from mild dandruff to persistent inflamed lesions. What we know: SD is linked to three main factors: increased sebum (oil) production, colonization by Malassezia  yeast, and an abnormal immune response. Genetics, skin barrier dysfunction, environmental triggers and stress also contribute to this condition (Adalsteinsson et al,  2020). Malassezia species, especially M.restricta  and M. globosa , are abundant in SD. These yeasts hydrolyse skin lipids, producing irritating fatty acids that drive inflammation (Tao et al , 2021). SD skin shows increased transepidermal water loss, reduced ceramides, and altered lipid composition, increasing irritation and microbial imbalance (Wikramanayake et al , 2019). Research highlights SD occurs across all skin types with treatment needs with preferred treatments varying across the population (Polaskey et al , 2024).   Industry impact and potential As insights into SD evolve, the industry has a unique chance to create smarter and more inclusive solutions. Microbiome-targeted products: Products that help regulate microbial balance, particularly, may help reduce flare-ups while preserving beneficial species. Barrier-supportive solutions: Lipids, ceramides, and pH-balanced systems can strengthen and enhance barrier resilience, addressing underlying weakness. Inclusive and culturally sensitive solutions: Treatments designed and tested across all skin tones and hair textures can ensure effectiveness across diverse users. Simplified treatment routines: Streamlined regimes can help to address consumer frustration with persistent symptoms and complex, time-consuming treatment. Our solution At Sequential, we support the development of next-generation seborrheic dermatitis solutions through deep microbiome profiling and multi-omic analysis. With a global database of 50,000+ samples, we help brands understand how Malassezia, bacterial communities, and barrier function interact across different skin and scalp types. We assess whether formulations rebalance the microbiome, strengthen the barrier, and target inflammation-related biomarkers, enabling the creation of microbiome-safe, inclusive, and effective products. Grounded in robust microbiome science, Sequential empowers brands to deliver targeted and culturally sensitive solutions for seborrheic dermatitis.   References: Adalsteinsson, J. et al. (2020)  Experimental Dermatology . https://doi.org/10.1111/exd.14091 Polaskey, M. et al. (2024)  JAMA Dermatology . https://doi.org/10.1001/jamadermatol.2024.1987 Tao, R. et al. (2021)  Experimental Dermatology . https://doi.org/10.1111/exd.14450 Wikramanayake, T. et al. (2019)  Experimental Dermatology . https://doi.org/10.1111/exd.140 06

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Throughout the year, Sequential has the pleasure of going to various conferences and trade shows where we talk all things microbiome testing and clinical studies. Don't miss us when we're in your city next! Connect With Us At Conferences At Sequential, we believe in the power of personal connections and the exchange of ideas to foster innovation and growth. As we actively participate in various conferences and industry events, we invite you to be a part of these enriching experiences. Explore the opportunities to engage with our team, discover the latest industry trends, and strengthen the bonds that drive mutual success. Join us at conferences to connect, learn, and pave the way for future collaborations. Where we will be in 2026 2-4 March Cambridge, United Kingdom 18-19 March Copenhagen, Denmark 14-16 April Paris, France 19-20 May New York City, USA 14 July Liverpool, United Kingdom 28 September - 1 October Perth, Australia 10-11 November Coventry, United Kingdom Microbiome Interactions in Health and Disease Our CEO & Co-founder, Dr. Oliver Worsley, will have the pleasure of attending this year. Microbiome Times Partnering Forum We are incredibly excited to be part of this forum, where we get to discuss with experts in the industry. In-cosmetics Global Have the pleasure of exhibiting and presenting at In-cosmetics Global. Come visit us at Booth (1A64) and listen to our CEO & Co-founder, Dr. Oliver Worsley, speak on “Advancing Personal Care Claims with integrated Human and Microbiome Data” on 14th April, Theatre 3 – 15.05 - 15.35. NYSCC Supplier's Day We are back at New York Supplier’s Day! (Booth information TBA) SCS Conference We will be attending the SCS Conference and look forward to connecting with industry peers. IFSCC Congress We are pleased to be attending the IFSCC Congress, engaging with the global cosmetics science community. SCS Formulate Visit us at Booth (600) at this year’s SCS Formulate to learn more about our work and speak with the team. Connect with us on Socials!

Seeking formulation support? Embark on the journey to your next best-selling product with our assistance. Let's collaborate and create success together! Create Your Next Best-Selling Formulation A well-designed formulation takes into account the diverse and delicate ecosystem of the microbiome. By incorporating ingredients that promote a harmonious relationship with the microbiota, such as prebiotics and postbiotics, a product can positively impact the microbial diversity and balance on the body. Having collected over 20,000+ human skin microbiome samples through in vivo clinical research, we can help you take your product from conception to completion. Consultation Book a consultation to start creating your microbiome supporting formulation. Whether you need help starting out or are already in the midst of your process, we can support you. INCI List Examination Have an INCI list and are unsure if it will be a formula? No need to look further, we will gladly look through your proposed INCI list and revert back with feedback. Co-Develop Let us be your Chief Science Officer, or your scientific advisory, and leverage our dataset for the co-development of products that suit your demographic and application. SKINCARE FORMULATIONS Regular to Atopic Skin, Start Formulating Today! What Contributes to a Microbiome Supporting Formulation? When creating a product that "maintains the microbiome", it is crucial to understand that every ingredient used is important. Hero ingredient-led philosophy cannot be applied in the formulation process as it is the blend of each ingredient that will create a product to support and improve the balance of the skin microbiome. Fermented ingredients (postbiotics) and those that act as food for microbes (prebiotics) are also known to have a positive impact on formulations when paired with the right preservative systems, surfactants, emollients, etc. It is still rare to find live bacteria (probiotics) in formulations, however, if encapsulated correctly, it could show improvement in the microbiome balance. Prebiotics Prebiotics beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria on the skin, and thus improves host health. Prebiotics act as food for the microbes on the skin, and allow good bacteria to grow and thrive. Probiotics Probiotics are living microorganisms that confer benefit to the host when applied to the body. Because probiotics are live bacteria, it is incredibly difficult to preserve and put into skincare products (especially when skincare contains preservatives). In fact, some products on the market that say they use probiotics, are actually using prebiotics or postbiotics. Postbiotics Postbiotics are the byproduct of fermented live bacteria (probiotics) or inactivated microorganisms. The process of fermentation releases nutrients inside of the bacteria and holds concentrated and nourishing skin health benefits that help to balance the skin microbiome. INGREDIENTS FROM MICROBIAL ORIGIN No INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? No Yes Yes ARE THEY VIABLE? No Yes ORIGIN VIABILITY FUNCTION ORDINARY INGREDIENT ORDINARY INGREDIENT WITH PREBIOTIC FUNCTION INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? PROBIOTIC INGREDIENT No POSTBIOTIC INGREDIENT Yes POSTBIOTIC INGREDIENT WITH PREBIOTIC FUNCTION Our Leading Expert & Skincare Director Pétronille Houdart A pharmacist by training, Pétronille specialized in dermo pharmacy and cosmetology. She has garnered extensive experience in the formulation of cosmetic products and is passionate about skincare. She started her career working for a private-label contract manufacturer that focused on custom cosmetic formulations for clients ranging from big brands to private dermatologist products. She has previously created a high-performance customisable formulation brand and is vocal about bespoke and innovative cosmetic formulations. Request a Consultation Ashfi Rahman, Co-founder at HonestStory "Sequential gave us completely essential consulting work on microbiome skincare formulations. They are the only company out there that combines their knowledge of microbiome testing with formulation expertise, and we're very happy to be working with them to develop the first microbiome skincare in India." FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.