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Global Leader for in vivo Microbiome Certification

Create a World of Healthier Microbiomes

In today's competitive market, it's crucial to find a unique selling point that sets your brand apart from the crowd. By harnessing the power of skin microbiome science, investing in in vivo testing, and obtaining the gold standard certification, you can create a competitive advantage that resonates with your customers.


Gold Standard Certification

Sequential is the gold standard for in vivo microbiome testing, using the most advanced analysis and sequencing technology to extract real and impactful conclusions.


Global Testing


Having developed a testing platform that transcends continents, Sequential’s certification is globally recognised by academics, professionals and brands across the world. 


Human Microbiome Testing

Sequential relies solely on the in vivo (in or on humans) approach due to the complex nature of the microbiome. The only meaningful way to test the microbiome is in vivo.


Proprietary Microbiome Panel

Having created a simpler approach to testing with our qPCR Smart Probes™, Sequential is able to measure the impact of a product against 20 key microbes down to strain level.

Why is Certification Crucial?

At present, there are no legal requirements when it comes to products claiming microbiome benefits. This is because the industry is still a young one, finding its footing and establishing its norms.

As a result, Sequential has developed an in vivo testing approach with 25 minimum participants per group study to ensure that our studies are acknowledged at the strictest academic level.

Unlike the in vitro approach, our in vivo certification is designed to demonstrate the true impact of all formulations in a real-life context on accurate application sites.


Rising Consumer Demand for Microbiome Supporting Formulations

At Sequential, we have carried out significant market research on the demand for products claiming microbiome benefits. 

The results of our market research on over 3,500 participants found that 80% demand a customised microbiome-based skincare product that factors ethnicity, age, location and skin concerns. Moreover, 65% understand that the skin microbiome provides a protective barrier on the surface of their skin, and 60% would spend more on a skincare product that can positively impact their skin microbiome. 

(Sequential market research in 2019: 99% women, ages 18+)



  • What is Sequential's testing platform?
    Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs.
  • Why is it necessary to test the microbiome in vivo?
    At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data.
  • What type of sequencing technology does Sequential use for analysis?
    We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome.
  • Does Sequential offer claims certification for tested products?
    We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.
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