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Join the team at Sequential! Explore exciting career opportunities in microbiome testing and research for the personal care industry. Build your future with us.

Understand Sequential's terms and conditions for using our website. Terms Of Use Last updated: 13 March 2024 Please read these terms of use ("Terms", "Terms of Use") carefully before using the www.sequential.bio website (the "Service") operated by Sequential Skin Ltd ("us", "we", or "our"). Your access to and use of the Service is conditioned on your acceptance of and compliance with these Terms. These Terms apply to all visitors, users, and others who access or use the Service. By accessing or using the Service, you agree to be bound by these Terms. If you disagree with any part of the terms, then you may not access the Service. Accounts When you create an account with us, you must provide us with information that is accurate, complete, and current at all times. Failure to do so constitutes a breach of the Terms, which may result in immediate termination of your account on our Service. You are responsible for safeguarding the password that you use to access the Service and for any activities or actions under your password, whether your password is with our Service or a third-party service. You agree not to disclose your password to any third party. You must notify us immediately upon becoming aware of any breach of security or unauthorized use of your account. Intellectual Property The Service and its original content, features, and functionality are and will remain the exclusive property of Sequential Skin Ltd and its licensors. The Service is protected by copyright, trademark, and other laws of both the UK and foreign countries. Our trademarks and trade dress may not be used in connection with any product or service without the prior written consent of Sequential Skin Ltd. Links To Other Web Sites Our Service may contain links to third-party web sites or services that are not owned or controlled by Sequential Skin Ltd. Sequential Skin Ltd has no control over, and assumes no responsibility for, the content, privacy policies, or practices of any third-party web sites or services. You further acknowledge and agree that Sequential Skin Ltd shall not be responsible or liable, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with use of or reliance on any such content, goods, or services available on or through any such web sites or services. We strongly advise you to read the terms and conditions and privacy policies of any third-party web sites or services that you visit. Termination We may terminate or suspend your account immediately, without prior notice or liability, for any reason whatsoever, including without limitation if you breach the Terms. Upon termination, your right to use the Service will immediately cease. If you wish to terminate your account, you may simply discontinue using the Service. Governing Law These Terms shall be governed and construed in accordance with the laws of England and Wales, without regard to its conflict of law provisions. Our failure to enforce any right or provision of these Terms will not be considered a waiver of those rights. If any provision of these Terms is held to be invalid or unenforceable by a court, the remaining provisions of these Terms will remain in effect. These Terms constitute the entire agreement between us regarding our Service, and supersede and replace any prior agreements we might have between us regarding the Service. Changes We reserve the right, at our sole discretion, to modify or replace these Terms at any time. If a revision is material, we will try to provide at least 30 days' notice prior to any new terms taking effect. What constitutes a material change will be determined at our sole discretion. By continuing to access or use our Service after those revisions become effective, you agree to be bound by the revised terms. If you do not agree to the new terms, please stop using the Service. Contact Us If you have any questions about these Terms, please contact us: - By email: team@sequential.bio - By visiting this page on our website: www.sequential.bio

Discover the power of combining microbiome testing and clinical data. Elevate your understanding with our comprehensive Clinical Assessments. Clinical Assessments for More In-Depth Analysis When it comes to testing your personal care products, we offer add-ons to supplement your microbiome research efforts and facilitate your testing experience. It has become clear in recent years that differentiation is key when creating a formulation for the competitive market, however, differentiation can be incredibly straightforward when backed with the data and scientific evidence to support it. Not only will you differentiate your brand, you will also demonstrate your commitment to providing leading-edge and effective solutions for your customers’ personal care and skincare needs. Start Your Biophysical Study Today! The only way to understand how a product performs is by putting it to the test Hydration Measurement (Corneometry and TEWL) Gain a comprehensive understanding of your product's impact on moisture retention, skin hydration and overall skin barrier function. This data can guide the development of effective moisturizing formulations. Perception Questionnaire Uncovering how users experience and interact with products. These surveys offer valuable insights into subjective factors like texture, scent, and overall satisfaction ensuring that your scientific data is enriched. Elasticity Measurement (Elastometer) Unravel the effect your product has on the skin’s elasticity through the use of elastometers, allowing you to position your product within a firming category with demonstrated benefits for graceful aging. High-Resolution Imaging Use before and after images to provide visual evidence of a product’s impact on the skin’s appearance. These tangible comparisons offer brands the ability to objectively assess changes in the skin. Dermatologist Assessment Measure and quantify inflammatory disease, atopic dermatitis (through SCORAD), psoriasis (through PASI), comedogenicity, and other hallmarks of skin conditions, by our board-certified and in-house dermatologists. Skin pH Measurement Maintain the delicate balance of the skin's acid mantle with your product by measuring pH to ensure compatibility and minimise the risk of irritation for a gentle, biome supporting formulation. FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Understand Sequential's cookie policy for using our website. Cookie Policy Last updated: 13 March 2024 Sequential Skin Ltd ("us", "we", or "our") operates the www.sequential.bio website (the "Service"). This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Service and the choices you have associated with that data. We use your data to provide and improve the Service. By using the Service, you agree to the collection and use of information in accordance with this policy. Unless otherwise defined in this Cookie Policy, the terms used in this Cookie Policy have the same meanings as in our Privacy Policy. Definitions Service: Service is the www.sequential.bio website operated by Sequential. Personal Data: Personal Data means data about a living individual who can be identified from those data (or from those and other information either in our possession or likely to come into our possession). Usage Data: Usage Data is data collected automatically either generated by the use of the Service or from the Service infrastructure itself (for example, the duration of a page visit). Cookies: Cookies are small pieces of data stored on your device (computer or mobile device). Data Controller: Data Controller means the natural or legal person who (either alone or jointly or in common with other persons) determines the purposes for which and the manner in which any personal information are, or are to be, processed. For the purpose of this Privacy Policy, we are a Data Controller of your Personal Data. Data Processors (or Service Providers): Data Processor (or Service Provider) means any natural or legal person who processes the data on behalf of the Data Controller. We may use the services of various Service Providers in order to process your data more effectively. Data Subject (or User): Data Subject is any living individual who is using our Service and is the subject of Personal Data. Information Collection and Use We use cookies and similar tracking technologies to track the activity on our Service and hold certain information. Types of Cookies We Use Session Cookies: We use Session Cookies to operate our Service. Preference Cookies: We use Preference Cookies to remember your preferences and various settings. Security Cookies: We use Security Cookies for security purposes. Advertising Cookies: Advertising Cookies are used to serve you with advertisements that may be relevant to you and your interests. Use of Data We use the collected data for various purposes: To provide and maintain our Service To notify you about changes to our Service To allow you to participate in interactive features of our Service when you choose to do so To provide customer support To gather analysis or valuable information so that we can improve our Service To monitor the usage of our Service To detect, prevent and address technical issues Retention of Data We will retain your Personal Data only for as long as is necessary for the purposes set out in this Cookie Policy. We will retain and use your Personal Data to the extent necessary to comply with our legal obligations (for example, if we are required to retain your data to comply with applicable laws), resolve disputes, and enforce our legal agreements and policies. Your Choices Regarding Cookies If you'd like to delete cookies or instruct your web browser to delete or refuse cookies, please visit the help pages of your web browser. Please note, however, that if you delete cookies or refuse to accept them, you might not be able to use all of the features we offer, you may not be able to store your preferences, and some of our pages might not display properly. Service Providers We may employ third party companies and individuals to facilitate our Service ("Service Providers"), provide the Service on our behalf, perform Service-related services, or assist us in analyzing how our Service is used. These third parties have access to your Personal Data only to perform these tasks on our behalf and are obligated not to disclose or use it for any other purpose. Changes to This Cookie Policy We may update our Cookie Policy from time to time. We will notify you of any changes by posting the new Cookie Policy on this page. You are advised to review this Cookie Policy periodically for any changes. Changes to this Cookie Policy are effective when they are posted on this page. Contact Us If you have any questions about this Cookie Policy, please contact us: By email: team@sequential.bio By visiting this page on our website: www.sequential.bio

Elevate your research with our expert clinical subject recruitment services. Rely on us for top-notch microbiome collection and analysis. Take control now! Simplify your Study Protocols with our Tailored Candidate Recruitment Highlight your specific requirements for clinical test subjects and we will take care of the entire candidate recruitment process for you, whether it is in-person or remote. This allows us to closely supervise and guarantee the quality of microbiome collection. 10,000+ Subject Database We offer candidate recruitment across a diverse pool of candidates to give better insights into how certain formulations work with individuals of different backgrounds. In Lab or Remote Testing The nature of our recruitment process is often linked to at-home testing, however, if you would prefer a controlled environment to test participants, we can arrange for testing to be conducted within our labs in Singapore, London and New York City. Simplified Recruitment Process As a global company, we pride ourselves in our reach and ensuring your study targets are met. We can recruit all the candidates required by the study regardless of geographical barriers. Longitudinal Studies Understanding the long-term impact of your formulation of personal care products is only possible with our in vivo solution which requires human participants to test the products on themselves. Why is a Human Approach Better when it Comes to Personal Care Product Testing? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. in vitro Lab Testing in vivo Human Testing Analyze select bacteria within a lab setting Narrow view of microbiome: Isolated from other bacteria Cannot extract meaningful conclusions on how the product will interact with its place of application Limited analysis: brief snapshot of how the product interacts with an isolated bacteria Analyze all bacteria within its natural context Broad view of microbiome: you can see interactions between bacteria Can extract meaningful conclusions on how the product will interact with its place of application Longitudinal analysis: evaluate the product over time and its impact on the microbiome Normal to Atopic Skin It’s crucial to test your product on individuals suffering through the concerns your active ingredients are targeting. This is why we believe in a fully personalized approach to candidate recruitment and human testing, bringing forward those individuals that your products are genuinely designed to help. FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

< Back Sales Associate (USA Based) East Coast of the United States, USA Job Type Full Time Workspace Hybrid About the Role As a Sales Associate at Sequential, you will be essential in building relationships and expanding our reach within the microbiome industry. Your role will involve supporting business development efforts, assisting in sales strategy execution, and helping grow market share for Sequential’s innovative products and services. You will work closely with the Sales Director and team to meet sales goals, develop client relationships, and contribute to Sequential’s mission of advancing microbiome science. This is a fantastic opportunity for an ambitious sales professional to gain hands-on experience and make a tangible impact in a rapidly growing biotech field. Essential Duties and Responsibilities: Sales Support and Development: Assist in the identification and acquisition of new customer accounts, supporting the growth of Sequential’s client base. Client Relationship Building: Cultivate relationships with existing and prospective clients, focusing on understanding their needs and promoting Sequential’s unique offerings. Market Research: Conduct ongoing research to stay informed on industry trends and competitor activity, providing valuable insights for sales strategies. CRM and Data Management: Maintain accurate records in our CRM (HubSpot), tracking interactions, progress, and key performance indicators. Sales Target Achievement: Work towards defined sales goals, contributing to Sequential’s revenue targets and growth ambitions. Collaborative Efforts: Work closely with marketing, product, and operations teams to align efforts and ensure a seamless customer experience. Product Knowledge Development: Stay up-to-date on Sequential’s product offerings and the latest microbiome research to effectively communicate value to clients. Qualifications and Experience: 1-2 years of sales experience, ideally within the biotechnology, cosmetics, or life sciences fields. Familiarity with CRM systems, preferably HubSpot, and the ability to manage data with accuracy. Strong written and verbal communication skills with a passion for client interaction and customer service. Tech-savvy and eager to leverage technology to enhance sales effectiveness. Bachelor's degree in Life Sciences, Business, or a related field preferred; demonstrated interest in microbiome or biotechnology is a plus. Motivated self-starter with a goal-oriented mindset and excellent organizational skills. Ability to work collaboratively and adapt in a dynamic, fast-paced environment. What You Get from Us: A base salary with a commission structure that rewards your hard work and success. Access to our Equity Incentive Plan, allowing you to grow alongside Sequential as we expand. The chance to work with industry experts in one of the fastest-growing sectors within biotechnology. Be part of a company at the forefront of microbiome research, making an impact in the biotechnology and healthcare fields. About the Company Sequential is a global leader in the skin microbiome field, a team of PhD experts in testing products and their effect on the human microbiome (skin, scalp, oral, vulva). An Innovate UK- and Enterprise Singapore-backed company, with labs in London, New York City and Singapore. Awarded the title "Most Significant" Testing Solution in the Industry - (C&T, 2022). To date, Sequential has amassed over 25,000 human skin microbiome samples and corresponding formulations tested in vivo on the skin. With this vast genomic dataset, Sequential are figuring out optimal formulations that could potentially alleviate skin conditions, for example – acne, atopic dermatitis and rosacea. They have been supported by Innovate UK, Enterprise SG, A*STAR (Genome Institute of Singapore). They have raised $4.3MM USD to date from SOSV, Metaplanet, Scrum Ventures, Corundum Systems Biology and are a resident company of JLABS Innovation (in NYC). Apply Now

Sequential Skin has developed the Skin Microbiome Test Kit to discover the state of skin microbiomes. You can do Skin Health Check to find what your skin needs. Sequential Skin has developed the first of its kind skin health test to discover the state of individuals' skin microbiome. People can now deep dive into their Skin Profile to figure out what their skin needs. Test your skin microbiome Benefits of your Skin Profile Skin Health Understand the state of your skin through your Skin Microbiome Balance Index score Skin Traits Learn about your skin traits through our in-app quiz and solutions for healthier skin Skin Age Discover your skin age and whether or not your skin is older/younger than you are Environment Unearth how your physical environment is impacting your skin microbiome Sample Register your kit: Register your kit on our Skin Health Tracker mobile app and answer the in-app quiz. Our Testing Technology Our microbiome test is the most comprehensive test on the market. We use a method known as quantitative real-time PCR (qPCR) that looks at specific markers in your skin microbiome and how they impact your skin. Skin Health Testing Kit Partner with Sequential Skin to bring our innovative skin health test to your customers. Give them an in-depth analysis of what lies on the surface of their skin and how best to increase its overall wellbeing. Register your Interest Frequently Asked Questions How is the sample collected? We recommend taking the test first thing in the morning, before you shower or wash your face, so the patch captures a sample when your skin is in its most natural state. Simply stick the Sequential patch on your forehead (adhesive side down) for 10 seconds and then put it in the test tube provided, and mail it back to us. More thorough instructions are included in the test kit. How long does it take to receive results? Results are received within 2-3 weeks. Where are the results received? Your skin microbiome test results can be accessed through the Skin Health Tracker mobile application. What will the report tell you? Your Sequential report gives you a clear and in-depth look at your Skin Microbiome Balance, which reflects the state of your skin microbiome and assesses the effects that your physical environment has on your skin. It will also highlight the age of your skin based on the test. How do you manage the heterogeneity within samples? “heterogeneity” comes in two forms - biological (people have different skin microbiome) and technical (experimental/sample collection/processing), the above points are addressing both Summarised more concisely here: Targeted Demographics: We work closely with clients to clearly define the target demographic and skin type. Strict Criteria: Inclusion and exclusion criteria minimize variability caused by treatments (e.g., antibiotics) or environmental differences (e.g., travel). Smart Probes: These evaluate absolute levels of microbes on the skin, enabling us to measure exact quantities, track changes over time, and identify trends across clinical samples. Synthetic Controls: Spike-in synthetic DNA controls manage variability during sample processing. Standardized Protocols: Consistent, validated protocols are used across all labs, and we handle DNA extraction and qPCR in-house to ensure reliability. Reproducible Sampling: Our skin patch collects samples from a consistent surface area for accurate and reproducible microbiome analysis. Biological variability: Targeted Demographics: We work closely with clients to clearly define the target demographic and skin type. Strict Criteria: Inclusion and exclusion criteria minimize variability caused by treatments (e.g., antibiotics) or environmental differences (e.g., travel). Technical variability: Smart Probes: These evaluate absolute levels of microbes on the skin, enabling us to measure exact quantities, track changes over time, and identify trends across clinical samples. Synthetic Controls: Spike-in synthetic DNA controls manage variability during sample processing. Standardized Protocols: Consistent, validated protocols are used across all labs, and we handle DNA extraction and qPCR in-house to ensure reliability. Reproducible Sampling: Our skin patch collects samples from a consistent surface area for accurate and reproducible microbiome analysis.

Elevate your brand with skin microbiome science. Gain a competitive edge with certified, innovative personal care products rooted in robust research. in vivo Sampling is the Future of Microbiome Testing We lead in clinical microbiome research and testing offering a comprehensive end-to-end platform designed to bring science-backed solutions to the personal care and pharma industry. We offer an expansive platform to conduct research on personal care products through microbiome testing, biophysical assessments, and offer full recruitment services for studies. We are keen to publish our findings with our partners to increase the literature within this space. At present our database of over 20,000 human microbiome samples is one of the most sophisticated within the industry and is growing rapidly. Skin Test your skincare products, ranging from facial cleansers, serums, moisturisers, and SPFs. Scalp Test your scalp care products ranging from scalp serums, oils, shampoos, and conditioners. Vaginal Test your intimate care products, ranging from washes, to hygiene sprays, and balms. Oral Test your oral care products ranging from mouth washes and toothpastes. Full End-To-End Testing Platform in vivo Study Design Collaborating closely with our clients to develop customised study protocols, ensuring that objectives are met with precision. Validated Collection Our non-invasive collection system consistently collects material for downstream analysis and allows for remote testing. Analysis & Reporting All analysis is carried out in-house allowing for a faster turn-around time on your study with exclusive access to our team of scientists and formulation experts. White Paper Publication Co-author a white paper with us based on the findings of your study to shorten the knowledge gap within the industry to demonstrate active's impact. Candidate Recruitment Carefully select human participants (location, age, etc.) to ensure the relevance and accuracy of the study. Microbiome Detection We offer four types of sequencing techniques including qPCR with our proprietary Smart Probes™, 16S, ITS and Shotgun Metagenomics. Claims Certification Providing comprehensive reports and certifications (Maintains the Microbiome seal) based on the study results which can be used in communication efforts. Co-Presentation We offer support by co-presenting at conferences where you want to demonstrate the impact of your study findings and explain the science behind the research. Start Your Clinical Study Today! State of the Art Sequencing Using next-generation sequencing of the collection of micro-organisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. With your pick from one of four sequencing reports, Sequential makes it easier to understand what depth of analysis is required for your particular needs. qPCR Microbiome (Bacteria+Fungi) Quantitative PCR (qPCR), also known as Real-Time PCR, is a method that Sequential uses in-house to measure the absolute number of copies of a microbial DNA defined by Sequential’s proprietary Smart Probes™. Using this method, we quantify the amount bacteria or fungi, allowing us to report level of species and strains within a given sample. The entire process is done at Sequential to ensure quality control, and extra control on your samples and privacy. Up Next-Generation Sequencing of ITS (total fungal population) ITS rRNA gene sequencing, or ITS amplicon sequencing is performed at Sequential to determine the relative abundance of taxa in a fungal community, and to compare between groups of interest. We know that fungi play a critical role in the microbiome of a healthy human, and it’s important to consider this application, especially for the scalp microbiome, and vaginal or vulva microbiome. We routinely offer two types of ITS rRNA primer regions: ITS1 & ITS2 Up Next-Generation Sequencing of 16S 16S rRNA gene sequencing, or 16S amplicon sequencing, is performed at Sequential to determine the relative abundance of taxa in a bacterial community, and to compare between groups of interest. This level of analysis can help to address changes in the overall bacterial profile over time or between treatment groups. We routinely offer two types of 16s rRNA primer regions: 16S V4 & 16S V1-V3 Up Shotgun Metagenomic Sequencing Shotgun metagenome sequencing is performed at Sequential for taxonomic profiling (diversity and abundance), as well as functional analysis across different organisms in a more exploratory approach. This complex technique allows for parallel sequencing of DNA from all organisms (bacterial, fungal, viral and human) within the community, with good coverage for species-level detection. The data generation allows for more advanced reporting and genome assemblies. Up FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Sequential is honoured to be spoken and written about in numerous publications. We are always keen to speak about the great milestones we are hitting with our personal care microbiome testing platform. Sequential in the Press Deep dive into Radiance Evaluation 9-Oct-2025 Read Now Men’s care shifts toward function-first to address skin needs beyond the basics 16-Sep-2025 Read Now Sequential and AMILI secure $1.8M UK-Singapore R&D project to advance gut-skin microbiome science 13-Feb-2025 Read Now New clinical testing to “investigate microbial roots of various skin conditions” 17-Oct-2024 Read Now Losing its meaning? ‘Microbiome-friendly’ terms at risk of misleading consumers – Sequential CEO 29-Jul-2024 Read Now Navigating the realm of intimate care products 17-Jan-2024 Read Now Avec ce test microbiome maison, 10 secondes m'ont suffit pour découvrir les besoins de ma peau 04-Oct-2023 Read Now Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin 3-Aug-2023 Read Now Sequential Announces New Collaboration Agreement to Measure Skin Health for Leading Developer of Personal Care Products 15-Mar-2023 Read Now Sequential Skin partners with Johnson & Johnson on microbiome tests 10-Mar-2023 Read Now Symbiome Partners with Skin Microbiome Testing experts at Sequential to Revolutionize Beauty Industry 26-Jan-2023 Read Now Sequential Skin Nabs $500K UK Grant to Study Skin Microbiome in Atopic Dermatitis 29-Jun-2022 Read Now Demands rising for clinical data on the skin microbiome: Experts 22-Mar-2022 Read Now ‘Maintaining the microbiome’: Biotech startup Sequential Skin debuts in vivo B2B testing service 03-Mar-2022 Read Now Start-up Sequential Skin bags $1.65m of fresh funding 12-Oct-2021 Read Now Singapore Beauty Startup Sequential Skin Uses Science to Help Identify the Best Skincare For You 07-Jan-2021 Read Now Overlooked opportunities? Skin microbiome may play a more important role in personalisation than DNA 13-Aug-2020 Read Now Sequential tool kit prioritises personalisation 15-Jan-2020 Read Now Sequential: Testing shows skin microbiome plays a role in hyperpigmentation 7-Oct-2025 Read Now The bidirectional skin-gut microbiome: a game-changer for cosmetic formulators 29-Jul-2025 Read Now Sequential and AMILI Secure Prestigious $1.8M UK-Singapore Collaborative R&D Project 13-Feb-2025 Read Now Sequential Launches Industry-First Microbiome Target Panels for Skin Conditions 16-Oct-2024 Read Now From the experts: Top 3 trends in skin microbiome research 20-Jun-2024 Read Now Is Home-Based Skin Microbiome Testing Transforming Beauty and Health Care Industry? 7-Dec-2023 Read Now “Hormone-led changes cause differences to the vaginal ecology that can have an effect on women’s health later in life.” CEO of Sequential 13-Sep-2023 Read Now Sequential and Johnson & Johnson enter partnership to develop new genomic-based skin test 16-Mar-2023 Read Now Sequential Announces New Collaboration Agreement to Quantify Skin Health 15-Mar-2023 Read Now ‘Natural evolution’: Gallinée unveils at-home skin microbiome test kits with Sequential Skin 09-Mar-2023 Read Now Here They Are: Congratulations to the Winners of the 2022 C&T Allēs 29-Sep-2022 Read Now Sequential Skin: Why We Invested 11-Apr-2022 Read Now Sequential Skin Debuts Sequential Bio Testing Solution 09-Mar-2022 Read Now Biotech Start-Up Sequential Skin Raises Funds 10-Dec-2021 Read Now Biotech startup Sequential Skin raises €1.4m – ‘We want to accelerate the future of skin health,’ says CEO 11-Oct-2021 Read Now PODCAST – Holistic view on skin: Sequential Skin on why microbiome testing is crucial to personalised beauty 21-Aug-2020 Read Now Beauté personnalisée: Sequential Skin la Beauty Tech made in Singapore 07-Jul-2020 Read Now GWS 2019 DAY 2 Beauty, Science & Technology: Skin in the Game 25-Nov-2019 Read Now Beautiful Bacteria: Are We On The Cusp Of Microbiome Mainstreaming? 28-Sep-2025 Read Now Sequential Skin and AMILI Secure $1.8M UK-Singapore Grant to Advance Gut-Skin Microbiome Science 14-Feb-2025 Read Now 50694 Gut microbiome differences between patients with moderate to severe Chronic Hand Eczema and healthy subjects Sep-2024 Read Now Is Microbiome Certification even Necessary? 29-Jul-2024 Read Now ‘It’s a really delicate system’: Research on vaginal microbiome shows how little we know about femcare 22-Jan-2024 Read Now Gallinée lance le premier test de santé de la peau et du microbiome à réaliser chez soi 10-Oct-2023 Read Now Lysine-dendrimer: a gentle yet effective acne treatment that maintains skin microbiome, says study 18-Aug-2023 Read Now Acne and ageing: J&J exploring skin health markers via Sequential Skin research tie-up 15-Mar-2023 Read Now Sequential Skin x Johnson & Johnson Collab to Quantify Skin Health 14-Mar-2023 Read Now Understand before purchase: Microbiome testing can help consumers find the right products and eliminate waste 30-Jan-2023 Read Now Sequential Wins New Grant To Propel Skin Microbiome Research 30-Jun-2022 Read Now Sequential Skin launches test to assess ingredient effect on microbiome 22-Mar-2022 Read Now Microbiome start-up Sequential Bio debuts first in-vivo testing for personal care industry 04-Mar-2022 Read Now Sequential Skin Raises $1.6M in Oversubscribed Seed Round 12-Oct-2021 Read Now The skin microbiome brainstorm: Tech, claims and trend-driven NPD 16-Sep-2021 Read Now Skin Sensors Enable Personalized Skin Care 20-Aug-2020 Read Now Sequential Skin: beauty tech’s new approach to genetic analysis and microbiome skincare 09-Mar-2020 Read Now How genetic insights can personalise skin microbiome launches 29-Jul-2019 Read Now

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By conducting in vivo testing, companies can better assess how sunscreen and SPF products interact with the microbiome, ensuring not only UV protection but also the maintenance of a healthy skin barrier. TARGETED SKIN PANEL Sun/UV Targeted Panel 23 Smart Probes ™ Sun/UV Panel Validated targets: Sphingomonas spp, Micrococcus luteus, Malassezia furfur Absolute Quantification End-to-end Service Qet a Quote Unlock the Secrets of UV Exposure with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for SPF Products? According to the Skin Cancer Foundation, about 1 in 5 Americans will develop skin cancer by the age of 70, with UV exposure being one of the most common causes. With the growing awareness of the risks associated with UV damage, in vivo testing for SPF products has become increasingly crucial. The skin microbiome plays a pivotal role in protecting against UV radiation, but excessive sun exposure can disrupt this delicate balance, leading to increased risk for skin cancer and other forms of skin damage. By conducting in vivo testing, companies can better assess how sunscreen and SPF products interact with the microbiome, ensuring not only UV protection but also the maintenance of a healthy skin barrier. This holistic approach is essential to create safer, more effective sun-care products that prevent long-term damage (American Academy of Dermatology). Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of UV exposure at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of sun-exposed microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to UV exposure, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New SPF products or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with sun exposure and UV related skin conditions. Smart Probe s ™ Our dedicated team of scientists has developed an innovative method for evaluating the effects of sun exposure and UV radiation on the skin using our Smart Probes™ technology. This proprietary panel features 23 key markers that we’ve identified as having the most significant influence on skin health, particularly in response to UV damage. To further understand the impact of UV radiation on the skin’s microbiome and overall health, we utilize qPCR technology. This advanced technique allows us to accurately measure changes in microbial populations and skin health following sun exposure. By closely analyzing how sun care products interact with these key markers and microbes, companies can develop solutions that not only protect against UV damage but also support the skin’s natural defenses, ensuring long-term skin health and resilience against sun-induced aging and other effects. Sun/UV Panel Targets Sphingomonas Sphingomonas has been shown to be highly resistant to UV irradiation and capable of reducing reactive oxygen species (ROS) levels in human keratinocytes—the predominant cell type in the epidermis. This discovery underscores the important role that members of the skin microbiome, such as Sphingomonas , play in protecting human skin from solar radiation damage. By mitigating oxidative stress caused by UV exposure, Sphingomonas may contribute to healthier skin and potentially enhance the skin's natural defense mechanisms. Harel N, Ogen-Shtern N, Reshef L, Biran D, Ron EZ, Gophna U. Skin microbiome bacteria enriched following long sun exposure can reduce oxidative damage. Res Microbiol. 2023 Nov-Dec;174(8):104138. doi: 10.1016/j.resmic.2023.104138. Epub 2023 Sep 16. PMID: 37722498. Micrococcus luteus Cyanobacteria have shown potential in skin care due to their ability to decrease pigmentation and reduce damage associated with photoaging. According to research, Cyanobacteria on the skin surface can help mitigate these effects by lowering melanin production and protect the skin from oxidative stress, which contributes to the aging process. Skowron K, Bauza-Kaszewska J, Kraszewska Z, Wiktorczyk-Kapischke N, Grudlewska-Buda K, Kwiecińska-Piróg J, Wałecka-Zacharska E, Radtke L, Gospodarek-Komkowska E. Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms. 2021 Mar 5;9(3):543. doi: 10.3390/microorganisms9030543. PMID: 33808031; PMCID: PMC7998121. Malassezia furfur Malassezia furfur is a species of yeast commonly found on human skin, often associated with various dermatological conditions. Despite its ability to synthesize a UV-protective substance called pityriacitrin, Malassezia furfur demonstrates high sensitivity to ultraviolet (UV) radiation. Burns EM, Ahmed H, Isedeh PN, Kohli I, Van Der Pol W, Shaheen A, Muzaffar AF, Al-Sadek C, Foy TM, Abdelgawwad MS, Huda S, Lim HW, Hamzavi I, Bae S, Morrow CD, Elmets CA, Yusuf N. Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome. Exp Dermatol. 2019 Feb;28(2):136-141. doi: 10.1111/exd.13854. Epub 2019 Jan 14. PMID: 30506967; PMCID: PMC7394481. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research Seasonal Shifts in the Skin Microbiome: Exploring Dynamic Changes Across the Year Shedding Light on Summer Sun: Does UV Exposure Affect the Skin Microbiome? Read More Articles

What is a Skin Microbiome? The first layer of defense for your skin against outside forces is made up of good bacteria. A diverse microbiome means healthy skin. The secrets behind your skin microbiome On the surface of your skin sits an organic ecosystem made up from billions of good bacteria called the microbiome. It forms the first layer of defense for your skin against outside forces. In order for your skin microbiome to be healthy, it must be balanced. A balanced microbiome means healthy skin What affects your skin microbiome? Your environment The country you live in can have adverse effects on your skin microbiome, from pollution levels to UV exposure. Your skin care routine When it comes to skin care, not knowing what products to use can negatively impact your skin microbiome. Your physical wellbeing What you put in your body is as important as what you put on it. A healthy diet can affect your skin health. Your mental health When you aren’t well internally, it can be a struggle to look after yourself. It is imperative to be aware of your mental health. Frequently asked questions What is your skin microbiome? Your skin microbiome is formed of the billions of microbes that sit on the surface of your skin but also line the gut, mouth, and other parts of the body. At Sequential Skin, we focus solely on your skin microbiome, testing it and providing you with solutions to balance it. Your microbiome is essential to your skin health and it is unique to you. What does it mean to have a balanced microbiome? Your skin microbiome health is measured by how equally dispersed the bacteria on your skin are compared to one another. When one or more bacteria dominate others, you might face skin conditions such as acne, rosacea, and eczema. Our test measures 20 microbes and provides you with a full report so you can transcend your skin to its optimal level. What affects your skin microbiome? The skin microbiome is largely impacted by your external environment, such as your location, pollution levels, and the skincare products that you use. This means that your skin is ever-changing and constantly adapting to different elements. It’s also influenced by internal factors, like gut health, making it unique to each of us. How can your skincare routine affect your skin microbiome? If you are using harsh ingredients that contain alcohol and irritants, it can severely disbalance your skin microbiome. You may think you are using products that are helping your skin, but instead, they are having adverse effects. This is why it is so important to test your skin microbiome and see if you might need a change of routine. Unearth the secrets of your skin microbiome We are skin experts We are a team of award-winning scientists with a mission to empower individuals to make better-informed decisions about their skin health. Our Story