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How to Test My Microbiome at Home? How to Test My Microbiome at Home? Advancements in next-generation sequencing (NGS) have made it easier for consumers to analyse their microbiome at home, providing insights into digestion, immune function and risks for chronic conditions like obesity and inflammatory bowel disease. (Kashyap et al., 2013; Mills et al., 2019) What was once confined to research labs is now accessible to individuals through at-home testing kits. Testing your microbiome at home involves using specialised kits that analyse stool, saliva, or skin samples to provide insights into the composition of your microbiota. At-Home Microbiome Testing Walkthrough Choose a Testing Kit: Several companies offer microbiome testing kits that can be purchased online. The most common ones focus on gut bacteria via stool samples, while others may analyse saliva or skin samples. Sample Collection: The kit will come with tools to collect your sample, usually a test tube for stool, saliva, or skin swabs. Each kit typically contains instructions, a sterile collection tool, a labelled container for the sample, and a prepaid shipping label to send the sample back to the lab for analysis. Return Your Sample: After collecting the sample, you place it in the provided container, label it, and use the prepaid shipping label to return it to the lab. DNA Analysis: Once the sample reaches the lab, it undergoes DNA sequencing, usually through next-generation sequencing (NGS) techniques. This process identifies the types and quantities of bacteria and other microbes in the sample. (Franzosa et al., 2018) Results: After the analysis, the company provides a detailed report of your microbiome, including the diversity and relative abundance of microbes. Some tests may offer personalised health or dietary recommendations based on your microbiome profile. (Mills et al., 2019) Actionable Insights: Based on your results, you may be able to adjust your diet or lifestyle to improve your microbiome balance and overall health. Conclusion At-home microbiome testing relies on the use of NGS, which sequences the DNA of the microorganisms in your sample. This technology has been validated in numerous scientific studies and is widely used in microbiome research. (Turnbaugh et al., 2007) Companies typically compare your microbiome profile against large databases of microbial genomes to provide insights into how your microbiome compares to others in terms of diversity and health markers. (Human Microbiome Project Consortium, 2012) While at-home microbiome tests are an exciting development in personalised health and have become a beacon in providing valuable information, it’s important to note that the science is still evolving. The relationships between specific microbes and health conditions are not fully understood yet and more research is needed to translate these findings into actionable clinical advice (Zhernakova et al., 2016). As research into the human microbiome continues, these tests will likely become even more accurate and influential in shaping personalised health strategies. References Franzosa, E. A., McIver, L. J., Rahnavard, G., Thompson, L. R., Schirmer, M., Weingart, G., … & Huttenhower, C. (2018). Species-level functional profiling of metagenomes and metatranscriptomes. Nature Methods, 15(11), 962-968. https://doi.org/10.1038/s41592-018-0176-y Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486(7402), 207-214. https://doi.org/10.1038/nature11234 Kashyap, P. C., Marcobal, A., Ursell, L. K., Smits, S. A., Sonnenburg, E. D., Costello, E. K., ... & Sonnenburg, J. L. (2013). Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proceedings of the National Academy of Sciences, 110(42), 17059-17064. https://doi.org/10.1073/pnas.1306070110 Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016). The healthy human microbiome. Genome Medicine, 8(1), 51. https://doi.org/10.1186/s13073-016-0307-y Mills, S., Stanton, C., Lane, J. A., Smith, G. J., & Ross, R. P. (2019). Precision nutrition and the microbiome, part I: Current state of the science. Nutrients, 11(4), 923. https://doi.org/10.3390/nu11040923 Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., … & Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-215. https://doi.org/10.1038/nature25973 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., … & Wijmenga, C. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565-569. https://doi.org/10.1126/science.aad3369

Sequential is pleased to announce the opening of it's first European lab based in London. We look forward to bringing our clinical microbiome testing service for personal care products to the UK and greater European market. Unveiling Sequential Bio’s New London Lab testing HQ 18th October 2022 - In an effort to keeping the entire testing process in-house, allowing for rigorous quality control, and meeting the demand of our European clients - today we announce the opening of our testing lab in London. Sequential is proud to announce that it will open a European HQ, and testing lab site in White City, London. One key quality that makes Sequential stand out from its competitors is keeping the testing protocols and quantitative analysis in-house. This gives them the ability to ensure the processing, and targeting of microbiome markers for their clients is extremely high quality. “Innovative R&D, and rigorous quality control on our lab testing and processes have always been front of mind at Sequential. By opening a lab in London, we’re responding to the demand from customers - whilst retaining control over our quality in testing.” - Dr Oliver Worsley, CEO/Co-Founder. Adding to their testing labs in Singapore, and New York, in which they serve Singapore, Thailand, Australia, and the US markets. This enables faster turnaround time for European clients, as the demand for non-invasive molecular analysis of the skin reaches new heights in Europe. Between 2018 - 2022, there have been over 34 microbiome deals (licensing and investments) made. With an average contract value of $257M, this has created over $2.3B of value in the gut and skin microbiome space. Europe is a significant player in the global microbiome field, expected to grow at a CAGR of 24.25% (between 2022-2028). About Sequential Sequential is part of the Sequential Skin group – with a US lab in New York City, alongside a lab in London and a lab in Singapore. Sequential Bio team has over 20 years of combined expertise in genetics, epigenetics, and microbiome research. It was recognised recently as the “Most Significant ” Testing Method in the Industry. Sequential has validated its AI-driven testing platform with over 30 companies, analyzing over 12,000 skin microbiome samples. They specialise in skin, scalp and vulva/vaginal microbiome samples. They are supported by Enterprise SG, A*STAR, Genome Institute of Singapore, IndieBio New York, SOSV, Metaplanet Holdings, Scrum Ventures, Genedant VC, Ben Holmes (ex. General Partner at Index Ventures), Innovate UK, and are a resident company of Johnson & Johnson Innovation – JLABS.

By conducting in vivo testing, companies can better assess how sunscreen and SPF products interact with the microbiome, ensuring not only UV protection but also the maintenance of a healthy skin barrier. TARGETED SKIN PANEL Sun/UV Targeted Panel 23 Smart Probes ™ Sun/UV Panel Validated targets: Sphingomonas spp, Micrococcus luteus, Malassezia furfur Absolute Quantification End-to-end Service Qet a Quote Unlock the Secrets of UV Exposure with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for SPF Products? According to the Skin Cancer Foundation, about 1 in 5 Americans will develop skin cancer by the age of 70, with UV exposure being one of the most common causes. With the growing awareness of the risks associated with UV damage, in vivo testing for SPF products has become increasingly crucial. The skin microbiome plays a pivotal role in protecting against UV radiation, but excessive sun exposure can disrupt this delicate balance, leading to increased risk for skin cancer and other forms of skin damage. By conducting in vivo testing, companies can better assess how sunscreen and SPF products interact with the microbiome, ensuring not only UV protection but also the maintenance of a healthy skin barrier. This holistic approach is essential to create safer, more effective sun-care products that prevent long-term damage (American Academy of Dermatology). Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of UV exposure at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of sun-exposed microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to UV exposure, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New SPF products or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with sun exposure and UV related skin conditions. Smart Probe s ™ Our dedicated team of scientists has developed an innovative method for evaluating the effects of sun exposure and UV radiation on the skin using our Smart Probes™ technology. This proprietary panel features 23 key markers that we’ve identified as having the most significant influence on skin health, particularly in response to UV damage. To further understand the impact of UV radiation on the skin’s microbiome and overall health, we utilize qPCR technology. This advanced technique allows us to accurately measure changes in microbial populations and skin health following sun exposure. By closely analyzing how sun care products interact with these key markers and microbes, companies can develop solutions that not only protect against UV damage but also support the skin’s natural defenses, ensuring long-term skin health and resilience against sun-induced aging and other effects. Sun/UV Panel Targets Sphingomonas Sphingomonas has been shown to be highly resistant to UV irradiation and capable of reducing reactive oxygen species (ROS) levels in human keratinocytes—the predominant cell type in the epidermis. This discovery underscores the important role that members of the skin microbiome, such as Sphingomonas , play in protecting human skin from solar radiation damage. By mitigating oxidative stress caused by UV exposure, Sphingomonas may contribute to healthier skin and potentially enhance the skin's natural defense mechanisms. Harel N, Ogen-Shtern N, Reshef L, Biran D, Ron EZ, Gophna U. Skin microbiome bacteria enriched following long sun exposure can reduce oxidative damage. Res Microbiol. 2023 Nov-Dec;174(8):104138. doi: 10.1016/j.resmic.2023.104138. Epub 2023 Sep 16. PMID: 37722498. Micrococcus luteus Cyanobacteria have shown potential in skin care due to their ability to decrease pigmentation and reduce damage associated with photoaging. According to research, Cyanobacteria on the skin surface can help mitigate these effects by lowering melanin production and protect the skin from oxidative stress, which contributes to the aging process. Skowron K, Bauza-Kaszewska J, Kraszewska Z, Wiktorczyk-Kapischke N, Grudlewska-Buda K, Kwiecińska-Piróg J, Wałecka-Zacharska E, Radtke L, Gospodarek-Komkowska E. Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms. 2021 Mar 5;9(3):543. doi: 10.3390/microorganisms9030543. PMID: 33808031; PMCID: PMC7998121. Malassezia furfur Malassezia furfur is a species of yeast commonly found on human skin, often associated with various dermatological conditions. Despite its ability to synthesize a UV-protective substance called pityriacitrin, Malassezia furfur demonstrates high sensitivity to ultraviolet (UV) radiation. Burns EM, Ahmed H, Isedeh PN, Kohli I, Van Der Pol W, Shaheen A, Muzaffar AF, Al-Sadek C, Foy TM, Abdelgawwad MS, Huda S, Lim HW, Hamzavi I, Bae S, Morrow CD, Elmets CA, Yusuf N. Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome. Exp Dermatol. 2019 Feb;28(2):136-141. doi: 10.1111/exd.13854. Epub 2019 Jan 14. PMID: 30506967; PMCID: PMC7394481. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research Seasonal Shifts in the Skin Microbiome: Exploring Dynamic Changes Across the Year Shedding Light on Summer Sun: Does UV Exposure Affect the Skin Microbiome? Read More Articles

Download your Personal Skin Health Tracker app by Sequential Skin to receive your microbiome test results and unlock personalized skincare tips. Get it now! The skin health tracker Benefit of your personal Skin Health Tracker Download your personal Skin Health Tracker app to receive your microbiome test results and unlock personalized skincare tips. Results Skin Profile Receive your comprehensive skin microbiome sample results. Results Accessibility Access to your Skin Profile results in the palm of your hand. Results Unlock Our Expertise Learn skincare tips to help you with your own perceived skin traits. Results Discover Learn more about the skin microbiome through our Discover articles. Frequently asked questions What is the Skin Health Tracker? The Skin Health Tracker is a mobile application that can be downloaded on iOS and Google Play that will help you track your skin over time. Once you have ordered your kit and activated it, you will receive the results of your test on your Skin Health Tracker within 2-3 weeks. What are the benefits of the app? You will have access to your Skin Profile at the touch of your hand. It is always accessible as it is on your mobile phone. You will also have access to our Discoveries and skin tips which will help you to make better-informed decisions about your skin. What will your Skin Profile on the app tell you? Your Sequential report gives you a clear and in-depth look at your Skin Microbiome Balance Index score, which reflects the state of your skin microbiome and assesses the effects that your physical environment has on your skin. It will also highlight the age of your skin based on the test and give you tips on how to rebalance your skin microbiome. Unearth the secrets of your microbiome

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The Biome Mask has been created with the goal of maintaining the microbiome while targeting concerns such as skin dehydration and sensitivity. Introducing the Biome Mask™ Sequential Skin is proud to announce its biodegradable Biome Mask™ line designed to balance the skin microbiome and make your skin healthier. The Biome Mask™ line has five formulas to target five skin traits. Each is infused with serums that target specific concerns and uses prebiotics and postbiotics to balance the skin's microbiome. All masks have been tested in vivo. Made for all skin types Our formula, your benefits Semi-gel Tencel™ Versatile, soft & pleasant to the skin Eco-friendly Material Better for you and the planet 100% Cellulose Cellulose is the most abundant natural organic compound on Earth Remarkable Moisture Retention For long lasting benefits Click Here to see a Full List of our Ingredients How They Work Prebiotics Prebiotics beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria on the skin, and thus improves host health. Feed your skin microbiome! Prebiotics act as good for the microbes on the skin, and allow good bacteria to grow and thrive. Probiotics Probiotics are living microorganisms that confer benefit to the host when applied to the body. Because probiotics are live bacteria, it is incredibly difficult to preserve and put into skincare products (especially when skincare contains preservatives). In fact, some products on the market that say they use probiotics, are actually using prebiotics or postbiotics. Postbiotics Postbiotics are the byproduct of fermented live bacteria (probiotics) or inactivated microorganisms. The process of fermentation releases nutrients inside of the bacteria and holds concentrated and nourishing skin health benefits that help to balance the skin microbiome. INGREDIENTS FROM MICROBIAL ORIGIN No INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? No Yes Yes ARE THEY VIABLE? No Yes ORIGIN VIABILITY FUNCTION ORDINARY INGREDIENT ORDINARY INGREDIENT WITH PREBIOTIC FUNCTION INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? PROBIOTIC INGREDIENT No Yes POSTBIOTIC INGREDIENT POSTBIOTIC INGREDIENT WITH PREBIOTIC FUNCTION Also available in a box of 5 Biome Masks™ Interested? Frequently asked questions What is the Biome Mask™ made from? We provide Semi-Gel Tencel masks that are made of 100% cellulose material and are eco-friendly. Each one of our masks is infused with serums that target your specific skin care needs. Semi-gel Tencel masks have the remarkable ability to retain moisture, making them better than cotton sheet masks and feel softer on the skin. What ingredients are used in the Biome Mask™? Each of our sheet masks comes with a fully transparent list of ingredients used in the mask. We do not use any of the following in our sheet masks: irritants, fragrances, essential oils, sulfates, formaldehyde releasers, nanoparticles, ethanolamines, and alcohol. Are the masks biodegradable? Yes, each Biome Mask™ is made of semi-gel Tencel, which is 100% biodegradable. What is the shelf life of the masks? You can find the manufacturing and best before date details printed on the front of the mask sachet. Please note that when the packaging is opened, the Biome Mask™ must be used immediately. What is the purpose of using a sheet mask? When it comes to skincare products, many don’t absorb into the skin, they evaporate, leaving none of the benefits to soak in. With sheet masks, a barrier is formed to lock in the ingredients and promote absorption resulting in plumper feeling skin. How long should the mask be left on the face? Our Biome Mask™ should be left on the skin for 15-20 minutes. Once you remove the mask, you can massage the excess formula into your skin for maximum benefit.

Video on how to take a microbiome sample with Sequential's microbiome testing kit.

Acne affects nearly 85% of people between the ages of 12 and 24, with millions worldwide continuing to struggle with breakouts into adulthood (American Academy of Dermatology). TARGETED SKIN PANEL Acne Targeted Panel 23 Smart Probes ™ Acne Panel Validated targets: Cutibacterium acnes acnes (subtype I) Cutibacterium acnes defendens (subtype II), Cutibacterium acnes elongatum (subtype III) Absolute Quantification End-to-end Service Qet a Quote Unlock the Secrets of Acne with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for Acne? Acne affects nearly 85% of people between the ages of 12 and 24, with millions worldwide continuing to struggle with breakouts into adulthood (American Academy of Dermatology). While many individuals turn to over-the-counter products in hopes of finding relief, the reality is that many of these formulations can exacerbate the problem. Without proper testing, products may contain ingredients that disrupt the delicate balance of the skin, leading to irritation, clogged pores, and even more severe acne. Acne isn’t just skin-deep — it’s driven by a delicate balance of microorganisms on the skin. As skincare companies race to meet demand, a lack of microbiome-focused testing means many products fail to address the root microbial causes of acne. Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of acne at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of acne-associated microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to acne-prone skin, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New acne treatments or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with acne development and severity. Smart Probe s ™ Our dedicated team of scientists has developed a groundbreaking method for evaluating microbes through our Smart Probes™, a proprietary panel featuring 23 key microbes specifically identified as having the greatest impact on skin health. To further explore the intricate connection between acne and the skin microbiome, we employ qPCR technology. This cutting-edge technique allows us to precisely measure microbial populations on the skin, providing a clearer understanding of how imbalances in the microbiome can contribute to acne breakouts. By carefully analyzing how skincare products interact with both beneficial and acne-causing microbes, companies can create solutions that not only target acne symptoms but also support a healthier, balanced skin microbiome, promoting clearer and more resilient skin. Acne Panel Targets Cutibacterium acnes acnes (Subtype I) Cutibacterium acnes subtype I is a specific strain of the C. acnes bacterium commonly found within sebaceous (oil) glands. This bacterium plays a key role in maintaining skin health by breaking down sebum, and producing fatty acids that prevent harmful pathogens from colonizing. However, certain strains of subtype I are associated with inflammatory conditions like acne vulgaris. While typically harmless, its overgrowth or imbalance in the skin microbiome can trigger immune responses that lead to acne and other skin issues. Spittaels KJ, Ongena R, Zouboulis CC, Crabbé A, Coenye T. Cutibacterium acnes Phylotype I and II Strains Interact Differently With Human Skin Cells. Front Cell Infect Microbiol. 2020 Nov 16;10:575164. doi: 10.3389/fcimb.2020.575164. PMID: 33330124; PMCID: PMC7717938. Cutibacterium acnes defendens (Subtype II) Cutibacterium acnes subtype II is a strain of the C. acnes bacterium, distinct from subtype I, and is found on human skin, primarily in sebaceous areas. While it shares similarities with other subtypes in maintaining skin health by metabolizing sebum, subtype II is less commonly associated with acne development. It has been linked more to opportunistic infections and medical device-related infections rather than inflammatory acne. Subtype II is typically less inflammatory than subtype I and plays a different role in the skin's microbial balance. Cobian N, Garlet A, Hidalgo-Cantabrana C, Barrangou R. Comparative Genomic Analyses and CRISPR-Cas Characterization of Cutibacterium acnes Provide Insights Into Genetic Diversity and Typing Applications. Front Microbiol. 2021 Nov 3;12:758749. doi: 10.3389/fmicb.2021.758749. PMID: 34803983; PMCID: PMC8595920. Cutibacterium acnes elongatum (Subtype III) Cutibacterium acnes subtype III is a less common strain of the C. acnes bacterium, primarily found in deeper skin layers and associated more with opportunistic infections rather than acne. Unlike subtypes I and II, which are typically found on the skin's surface and sebaceous areas, subtype III is linked to post-surgical infections, particularly around medical implants, and is less involved in acne formation. It tends to have lower inflammatory potential, distinguishing it from other C. acnes subtypes in terms of both location and clinical relevance. Dagnelie MA, Khammari A, Dréno B, Corvec S. Cutibacterium acnes molecular typing: time to standardize the method. Clin Microbiol Infect. 2018 Nov;24(11):1149-1155. doi: 10.1016/j.cmi.2018.03.010. Epub 2018 Mar 12. PMID: 29544912. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research Acne & The Skin Microbiome? Unveiling Nature's Acne Assassin: The Power of Essential Oils Benzoyl Peroxide & the Skin Microbiome Read More Articles

Search Results All (70) Research Articles (42) Other Pages (28) 70 items found Research Articles (42) Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised scar that forms within the boundaries of the original wound due to excessive collagen production during healing. While traditional wound dressings effectively promote healing, there’s growing interest in innovative approaches that address post-burn scarring more effectively. What We Know: Traditional dressings help close and heal wounds by providing hydration and antimicrobial protection, but they aren’t designed to prevent or treat post-burn scarring. Burns disrupt the skin’s microbial balance, favouring heat-loving microbes like Aeribacillus, Caldalkalibacillus and Nesterenkonia while reducing beneficial bacteria such as Cutibacterium, Staphylococci and Corynebacteria . Increased levels of Corynebacterium are linked to higher infection risks, whereas Staphylococci and Cutibacterium are associated with lower infection rates post-burn (Yang et al., 2024). Despite reduced bacterial richness at the genus level, burn patients exhibit increased microbial community diversity and evenness. This altered microbial landscape, marked by a lower overall bacterial burden and an overgrowth of Staphylococcus species, highlights a persistent dysbiotic state in the skin microbiota during the subacute phase of wound healing (Liu et al., 2018) . Industry Impact and Potential: @Healome Therapeutics has developed a groundbreaking bioactive skin dressing technology, recently cleared by the @Medicines and Healthcare products Regulatory Agency (MHRA) for a phase I trial aimed at reducing scarring. The trial, conducted at Queen Elizabeth Hospital in Birmingham, UK, involves 25 patients with burns covering 3-20% of their body surface. Healome’s innovative dressing is a clear film that not only offers the benefits of traditional wound dressings but also incorporates synthetic human-derived decorin protein, which plays a critical role in wound healing. This protein reduces the inflammatory response and regulates the wound’s microenvironment. Early research suggests that this approach may reduce fibrosis and promote tissue regeneration, offering new hope for scar management in burn patients. Products like Healome’s dressing showcase the exciting potential of using the microbiome and skin environment to enhance wound healing, paving the way for future innovations in burn care. Our Solution: At Sequential, we offer comprehensive services for evaluating product impacts and formulations, supported by a vast database of over 20,000 microbiome samples and 4,000 ingredients, along with a global network of more than 10,000 testing participants. Our customizable microbiome studies simulate real-world testing scenarios, ensuring that your products preserve biome integrity while delivering optimal results. References: Liu, S.-H., Huang, Y.-C., Chen, L.Y., Yu, S.-C., Yu, H.-Y. & Chuang, S.-S. (2018) The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 26 (2), 182–191. doi:10.1111/wrr.12632. Yang, Y., Huang, J., Zeng, A., Long, X., Yu, N. & Wang, X. (2024) The role of the skin microbiome in wound healing. Burns & Trauma. 12, tkad059. doi:10.1093/burnst/tkad059. Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced muscle strength, and reduced stress levels. Nevertheless, swimming also involves exposure to different water environments, including chlorinated pools, seawater, and freshwater lakes. Each of these environments possesses distinct chemical and microbial properties that can uniquely affect the skin microbiome. Consequently, comprehending the significance of the skin microbiome in swimming is essential. What we know: Studies have found that exposure to chlorinated pool water reduces microbial diversity on the skin, as it acts as a disinfectant, killing both harmful and beneficial bacteria, which can lead to an imbalance in the skin microbiome. This imbalance may increase the risk of skin conditions like dermatitis and infections (Puce et al ., 2022). Ocean water contains a diverse range of marine bacteria, thereby enhancing the diversity of the skin microbiome. The ocean water simultaneously removes resident skin bacteria while depositing ocean-borne bacteria onto the skin (Nielsen et al ., 2019). The predominating phyla Actinobacteria , Firmicutes , and Proteobacteria on the skin changed after swimming when compared to before swimming tends to decrease, whereas Bacteroidetes tends to increase. As time passed, the bacterial community composition trended towards baseline (Nielsen et al ., 2019). The quantity of Vibrio spp. found on human skin was over ten times higher than that in the ocean water sample (which was only 0.032%), indicating that Vibrio spp. has a particular affinity for adhering to human skin (Nielsen et al ., 2019). Industry impact & potential: Research shows that males are more prone to acquiring infections from Vibrio vulnificus and Aeromonas spp. following water exposure. Future research could provide valuable insights into the factors contributing to these infections and explore potential differences in the skin microbiome between males and females after such exposure (Nielsen et al ., 2019). Formulations such as post and pre-swim cleansers and moisturizers should be designed to aid in microbiome recovery while also protecting the skin from chlorine and salt damage. Our solution: Sequential, is a company focusing on microbiome studies. We carry out various services from clinical testing to helping with formulations. We have at home testing kits that will allow you to discover the state of your skin microbiome. Through our Skin Health Tracker app, we can give you tips on how you can improve your skin and the microbiome. Reference: Nielsen MC, Jiang SC. Alterations of the human skin microbiome after ocean water exposure. Mar Pollut Bull. 2019 Aug;145:595-603. doi: 10.1016/j.marpolbul.2019.06.047. Epub 2019 Jul 2. PMID: 31590829; PMCID: PMC8061468. Puce L, Hampton-Marcell J, Trabelsi K, Ammar A, Chtourou H, Boulares A, Marinelli L, Mori L, Cotellessa F, Currà A, Trompetto C, Bragazzi NL. Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature. Front Microbiol. 2022 Aug 3;13:984867. doi: 10.3389/fmicb.2022.984867. PMID: 35992695; PMCID: PMC9382026. Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on how rebalancing these microbes can significantly enhance the efficacy of treatments for hair loss, offering new hope for patients. What We Know: Cutibacterium spp. and Staphylococcus spp . constitute about 90% of healthy scalp microbiomes, with Corynebacterium spp., Streptococcus spp., Acinetobacter spp . and Prevotella spp . making up the remaining 10% (Jo et al., 2022) . Alopecia patients’ scalp microbiomes exhibit increased C. acnes , Stenotrophomonas geniculata, Wallemia and Eurotium , as well as reduced Malassezia, when compared to healthy individuals. Therefore, it is likely that an imbalance in scalp microbiota may contribute to alopecia (Zhang et al., 2024) . Industry Impact and Potential: Platelet-rich plasma (PRP) has proven effective in treating alopecia, but its impact on the scalp microbiome was previously unexplored. A recent study revealed that PRP treatment rebalances the scalp microbiome, specifically increasing Cutibacterium levels while decreasing Staphylococcus and Lawsonella levels (Zhang et al., 2024) . Cutibacterium plays a vital role in maintaining skin homeostasis and is crucial for lipid regulation, follicular niche competition, immune regulation and mitigating oxidative stress. Furthermore, the balance between Cutibacterium and Staphylococcus is important for regulating immune response. Reduction in Lawsonella suggests decreased scalp sebum production following treatment. This is relevant to alopecia treatment, as imbalances in sebum production can exacerbate hair loss by contributing to inflammation and follicle damage (Zhang et al., 2024) . Lactic acid bacteria (LAB), Limosilactobacillus fermentum LM1020 and its heat-treated version HT-LM1020, can help promote hair growth on human scalp tissue and dermal papilla cells. These bacteria work with other ingredients to fight hair loss by boosting cell growth and regulating the expression of proteins important for cell division (Bae et al., 2024) . AMOREPACIFIC patented a composition that uses extracellular follicles derived from LAB to prevent hair loss, stimulate hair growth and support overall hair health. These extracellular follicles (cellular components or secretions released by the bacteria) represent a promising advancement in alopecia treatment, offering potential benefits for both hair and scalp health. Our Solution: With a database of over 20,000 microbiome samples and 4,000 ingredients, and a global network of more than 10,000 testing participants, Sequential offers comprehensive services to evaluate product impacts and formulations. Our customisable microbiome studies provide real-life context testing, and our formulation support ensures products maintain biome integrity, making us the ideal partner for your product development and efficacy needs. References: Bae, W.-Y., Jung, W.-H., Shin, S.L., Kim, T.-R., Sohn, M., Suk, J., Jung, I., Lee, Y.I. & Lee, J.H. (2024) Heat-treated Limosilactobacillus fermentum LM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double-blind, randomized and placebo-controlled clinical trial. Journal of Cosmetic Dermatology . n/a (n/a). doi:10.1111/jocd.16357. Jo, H., Kim, S.Y., Kang, B.H., Baek, C., Kwon, J.E., Jeang, J.W., Heo, Y.M., Kim, H.-B., Heo, C.Y., Kang, S.M., Shin, B.H., Nam, D.Y., Lee, Y.-G., Kang, S.C. & Lee, D.-G. (2022) Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules . 27 (16). doi:10.3390/molecules27165136. Zhang, Q., Wang, Y., Ran, C., Zhou, Y., Zhao, Z., Xu, T., Hou, H. & Lu, Y. (2024) Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet‐rich plasma (PRP). Animal Models and Experimental Medicine . 7 (2), 106–113. doi:10.1002/ame2.12414. View All Other Pages (28) Search Results | Sequential Search Results All (70) Research Articles (42) Other Pages (28) 70 items found Research Articles (42) Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised scar that forms within the boundaries of the original wound due to excessive collagen production during healing. While traditional wound dressings effectively promote healing, there’s growing interest in innovative approaches that address post-burn scarring more effectively. What We Know: Traditional dressings help close and heal wounds by providing hydration and antimicrobial protection, but they aren’t designed to prevent or treat post-burn scarring. Burns disrupt the skin’s microbial balance, favouring heat-loving microbes like Aeribacillus, Caldalkalibacillus and Nesterenkonia while reducing beneficial bacteria such as Cutibacterium, Staphylococci and Corynebacteria . Increased levels of Corynebacterium are linked to higher infection risks, whereas Staphylococci and Cutibacterium are associated with lower infection rates post-burn (Yang et al., 2024). Despite reduced bacterial richness at the genus level, burn patients exhibit increased microbial community diversity and evenness. This altered microbial landscape, marked by a lower overall bacterial burden and an overgrowth of Staphylococcus species, highlights a persistent dysbiotic state in the skin microbiota during the subacute phase of wound healing (Liu et al., 2018) . Industry Impact and Potential: @Healome Therapeutics has developed a groundbreaking bioactive skin dressing technology, recently cleared by the @Medicines and Healthcare products Regulatory Agency (MHRA) for a phase I trial aimed at reducing scarring. The trial, conducted at Queen Elizabeth Hospital in Birmingham, UK, involves 25 patients with burns covering 3-20% of their body surface. Healome’s innovative dressing is a clear film that not only offers the benefits of traditional wound dressings but also incorporates synthetic human-derived decorin protein, which plays a critical role in wound healing. This protein reduces the inflammatory response and regulates the wound’s microenvironment. Early research suggests that this approach may reduce fibrosis and promote tissue regeneration, offering new hope for scar management in burn patients. Products like Healome’s dressing showcase the exciting potential of using the microbiome and skin environment to enhance wound healing, paving the way for future innovations in burn care. Our Solution: At Sequential, we offer comprehensive services for evaluating product impacts and formulations, supported by a vast database of over 20,000 microbiome samples and 4,000 ingredients, along with a global network of more than 10,000 testing participants. Our customizable microbiome studies simulate real-world testing scenarios, ensuring that your products preserve biome integrity while delivering optimal results. References: Liu, S.-H., Huang, Y.-C., Chen, L.Y., Yu, S.-C., Yu, H.-Y. & Chuang, S.-S. (2018) The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 26 (2), 182–191. doi:10.1111/wrr.12632. Yang, Y., Huang, J., Zeng, A., Long, X., Yu, N. & Wang, X. (2024) The role of the skin microbiome in wound healing. Burns & Trauma. 12, tkad059. doi:10.1093/burnst/tkad059. Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced muscle strength, and reduced stress levels. Nevertheless, swimming also involves exposure to different water environments, including chlorinated pools, seawater, and freshwater lakes. Each of these environments possesses distinct chemical and microbial properties that can uniquely affect the skin microbiome. Consequently, comprehending the significance of the skin microbiome in swimming is essential. What we know: Studies have found that exposure to chlorinated pool water reduces microbial diversity on the skin, as it acts as a disinfectant, killing both harmful and beneficial bacteria, which can lead to an imbalance in the skin microbiome. This imbalance may increase the risk of skin conditions like dermatitis and infections (Puce et al ., 2022). Ocean water contains a diverse range of marine bacteria, thereby enhancing the diversity of the skin microbiome. The ocean water simultaneously removes resident skin bacteria while depositing ocean-borne bacteria onto the skin (Nielsen et al ., 2019). The predominating phyla Actinobacteria , Firmicutes , and Proteobacteria on the skin changed after swimming when compared to before swimming tends to decrease, whereas Bacteroidetes tends to increase. As time passed, the bacterial community composition trended towards baseline (Nielsen et al ., 2019). The quantity of Vibrio spp. found on human skin was over ten times higher than that in the ocean water sample (which was only 0.032%), indicating that Vibrio spp. has a particular affinity for adhering to human skin (Nielsen et al ., 2019). Industry impact & potential: Research shows that males are more prone to acquiring infections from Vibrio vulnificus and Aeromonas spp. following water exposure. Future research could provide valuable insights into the factors contributing to these infections and explore potential differences in the skin microbiome between males and females after such exposure (Nielsen et al ., 2019). Formulations such as post and pre-swim cleansers and moisturizers should be designed to aid in microbiome recovery while also protecting the skin from chlorine and salt damage. Our solution: Sequential, is a company focusing on microbiome studies. We carry out various services from clinical testing to helping with formulations. We have at home testing kits that will allow you to discover the state of your skin microbiome. Through our Skin Health Tracker app, we can give you tips on how you can improve your skin and the microbiome. Reference: Nielsen MC, Jiang SC. Alterations of the human skin microbiome after ocean water exposure. Mar Pollut Bull. 2019 Aug;145:595-603. doi: 10.1016/j.marpolbul.2019.06.047. Epub 2019 Jul 2. PMID: 31590829; PMCID: PMC8061468. Puce L, Hampton-Marcell J, Trabelsi K, Ammar A, Chtourou H, Boulares A, Marinelli L, Mori L, Cotellessa F, Currà A, Trompetto C, Bragazzi NL. Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature. Front Microbiol. 2022 Aug 3;13:984867. doi: 10.3389/fmicb.2022.984867. PMID: 35992695; PMCID: PMC9382026. Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on how rebalancing these microbes can significantly enhance the efficacy of treatments for hair loss, offering new hope for patients. What We Know: Cutibacterium spp. and Staphylococcus spp . constitute about 90% of healthy scalp microbiomes, with Corynebacterium spp., Streptococcus spp., Acinetobacter spp . and Prevotella spp . making up the remaining 10% (Jo et al., 2022) . Alopecia patients’ scalp microbiomes exhibit increased C. acnes , Stenotrophomonas geniculata, Wallemia and Eurotium , as well as reduced Malassezia, when compared to healthy individuals. Therefore, it is likely that an imbalance in scalp microbiota may contribute to alopecia (Zhang et al., 2024) . Industry Impact and Potential: Platelet-rich plasma (PRP) has proven effective in treating alopecia, but its impact on the scalp microbiome was previously unexplored. A recent study revealed that PRP treatment rebalances the scalp microbiome, specifically increasing Cutibacterium levels while decreasing Staphylococcus and Lawsonella levels (Zhang et al., 2024) . Cutibacterium plays a vital role in maintaining skin homeostasis and is crucial for lipid regulation, follicular niche competition, immune regulation and mitigating oxidative stress. Furthermore, the balance between Cutibacterium and Staphylococcus is important for regulating immune response. Reduction in Lawsonella suggests decreased scalp sebum production following treatment. This is relevant to alopecia treatment, as imbalances in sebum production can exacerbate hair loss by contributing to inflammation and follicle damage (Zhang et al., 2024) . Lactic acid bacteria (LAB), Limosilactobacillus fermentum LM1020 and its heat-treated version HT-LM1020, can help promote hair growth on human scalp tissue and dermal papilla cells. These bacteria work with other ingredients to fight hair loss by boosting cell growth and regulating the expression of proteins important for cell division (Bae et al., 2024) . AMOREPACIFIC patented a composition that uses extracellular follicles derived from LAB to prevent hair loss, stimulate hair growth and support overall hair health. These extracellular follicles (cellular components or secretions released by the bacteria) represent a promising advancement in alopecia treatment, offering potential benefits for both hair and scalp health. Our Solution: With a database of over 20,000 microbiome samples and 4,000 ingredients, and a global network of more than 10,000 testing participants, Sequential offers comprehensive services to evaluate product impacts and formulations. Our customisable microbiome studies provide real-life context testing, and our formulation support ensures products maintain biome integrity, making us the ideal partner for your product development and efficacy needs. References: Bae, W.-Y., Jung, W.-H., Shin, S.L., Kim, T.-R., Sohn, M., Suk, J., Jung, I., Lee, Y.I. & Lee, J.H. (2024) Heat-treated Limosilactobacillus fermentum LM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double-blind, randomized and placebo-controlled clinical trial. Journal of Cosmetic Dermatology . n/a (n/a). doi:10.1111/jocd.16357. Jo, H., Kim, S.Y., Kang, B.H., Baek, C., Kwon, J.E., Jeang, J.W., Heo, Y.M., Kim, H.-B., Heo, C.Y., Kang, S.M., Shin, B.H., Nam, D.Y., Lee, Y.-G., Kang, S.C. & Lee, D.-G. (2022) Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules . 27 (16). doi:10.3390/molecules27165136. Zhang, Q., Wang, Y., Ran, C., Zhou, Y., Zhao, Z., Xu, T., Hou, H. & Lu, Y. (2024) Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet‐rich plasma (PRP). Animal Models and Experimental Medicine . 7 (2), 106–113. doi:10.1002/ame2.12414. View All Other Pages (28) Sequential Alle Awards | Sequential Allē Award: Sequential Wins Prestigious “Most Significant” Testing Method After being listed as a finalist as best ‘Claims testing methods & tools’ alongside Evonik, and XCellR8 - Sequential brings home top prize in C&T’s Allē Awards, 2022. ​ The personal care and cosmetics industry in the US is valued at $190B. In the context of the skin microbiome, the industry is still a relatively nascent field. However, its projected growth is significant, estimated to grow at a compounded annual growth of 29.2% between 2022-2028. Owed to the impact of products on the skin microbiome, consumer awareness, and understanding that our microbiome is intimately linked to our health. ​ Sequential is the B2B microbiome testing arm for Sequential Skin Ltd, which has developed the world’s first end-to-end platform for companies to evaluate their products on the microbiome in vivo. They specialize in skin, scalp and intimate area microbiome. ​ "Of all the 'microbiome friendly' methodologies working to address both consumer and industry concerns about the impact of cosmetics on the microbiome, this is, in my opinion, the most quantitative and promising of the lot." – C&T's Allē Award judges, 2022. ​ The company has developed a proprietary non-invasive method for collecting skin samples to analyze the skin microbiome using next-generation sequencing (NGS), with species and strain identification, in longitudinal (and clinical) studies. Services include data interpretation and the results are reported in a comprehensive, yet understandable format, ready for formulators and research scientists to incorporate into their product development pipeline. ​ “The Allē Award gives us strong confidence in the testing platform and capabilities we’ve built in Sequential. Being the first to develop an in vivo microbiome test for the industry, we’re proud to see our hard work paying off” — Petronille Houdart, DPharm, skincare director at Sequential. ​ ​ About Sequential ​ Sequential is part of the Sequential Skin group – with a US lab in New York City, alongside a lab in London and a lab in Singapore. Sequential team has over 20 years of combined expertise in genetics, epigenetics, and microbiome research. ​ Sequential has validated its AI-driven testing platform with over 30 companies, analyzing over 12,000 skin microbiome samples. They specialise in skin, scalp and vulva/vaginal microbiome samples. They are supported by Enterprise SG, A*STAR, Genome Institute of Singapore, IndieBio New York, SOSV, Metaplanet Holdings, Scrum Ventures, Genedant VC, Ben Holmes (ex. General Partner at Index Ventures), Innovate UK, and are a resident company of Johnson & Johnson Innovation – JLABS. Scalp Microbiome Testing | Sequential Scalp Microbiome Testing As the scalp care industry grows, consumers demand transparency from the brands formulating their products. It has become essential for formulators to create products they are willing to test to present scientifically backed data-driven evidence of their products' true effects. Sequential offers microbiome testing for your scalp care formulations, ranging from scalp serums, shampoos, conditioners, oils, etc. We are dedicated to understanding how your product interacts with the scalp and its microbes. Depending on how in-depth you want to go, we offer qPCR, 16S, ITS, and Shotgun Metagenomics. Download Case Study! Personalized Approach to Testing Unlike other methodologies present within the industry, Sequential's approach ensures that your product's data and analysis will stand the test of industry regulations when they are introduced. You can tailor your study entirely to your unique requirements. Test Products in a Real-Life Context The microbiome comprises a complex ecosystem of microorganisms that live together in a delicate balance, which is why it's best to test directly upon it directly. To fully understand the impact a product is having on the microbiome, in vivo is the only way. Collect Longitudinal Data With in vivo testing we can design your study around the extended use of a product over multiple time points. This allows us to review how a product is performing before and after usage, but also take into account its gradual impact on the microbiome. Measure Against a Control Group Measure a product against a control group that might have a different percentage of your active ingredient within its formulation or no active at all. This will allow for deeper insights into the impact of a formulation on microbial balance and diversity. 4 Sequencing Reports To Pick From Depending on your development stage and what you are interested in studying we offer qPCR, 16S, ITS, and Shotgun Metagenomics. With our qPCR Smart Probes™ we can go down to the strain level in our analysis. Personalize Your Microbiome Study! Unlike hair, the scalp is formed of a living community of microorganisms such as bacterial and fungal players that can influence the balance of the scalp microbiome, even the subtlest of imbalances can lead to issues such as dandruff, itching, and irritation, resulting in unwanted flaking. Smart Probe s ™ Our dedicated team of scientists have developed a method of evaluating microbes through our Smart Probes ™ . These refer to a panel of 20 key microbes we have specifically identified as having the most impact on scalp health. Over and above the taxonomic characterisation that 16S offers, which gives us a snapshot of all the genus present within a collected sample (Cutibacterium , Staphylococcus , etc.) our targeted approach takes it a step further, opening the lens to the species (C. acnes ), sub-species (C. acnes defendens ) and even strains within them. This is a crucial distinction as not all strains of a species behave similarly. We find that within these species there are strains associated with inflammation and strains that are commensal, and beneficial. Gold Standard Certification Sequential has developed the gold standard test for products designed to target the microbiome, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. ​ Using next-generation sequencing of the collection of micro-organisms found on the body, before and after product usage, Sequential investigates the microbial balance and diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. ​ We give you an in vivo certification that your product maintains the microbiome. And it’s not exclusive to skincare! We do this for haircare products, oral products, and vulva/vaginal microbiomes. Personalize Your Microbiome Study! Supplement Your Microbiome Study Recruitment Services Let us take care of the entire candidate recruitment process for you! View More Biophysical Assessments Increase your data on the use of your product by evaluating additional biophysical factors. View More Formulation Support Seek consultation advice for your formulation if you are re-formulating or developing a new product. View More FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations. Personal Skin Health Tracker - Sequential Skin - Skin age Test The skin health tracker Benefit of your personal Skin Health Tracker Download your personal Skin Health Tracker app to receive your microbiome test results and unlock personalized skincare tips. Results Skin Profile Receive your comprehensive skin microbiome sample results. Results Accessibility Access to your Skin Profile results in the palm of your hand. Results Unlock Our Expertise Learn skincare tips to help you with your own perceived skin traits. Results Discover Learn more about the skin microbiome through our Discover articles. What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations. Unearth the secrets of your microbiome View All Research | Sequential The Skin Microbiome Review All Posts White Papers Skin Microbiome Scalp Microbiome Vaginal Microbiome Oral Microbiome Baby Microbiome 33 minutes ago Skin Microbiome Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised... 6 days ago Skin Microbiome Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced... Aug 21 Scalp Microbiome Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on... Aug 16 Skin Microbiome Diabetes Dilemma: The Skin Microbiome’s Influence on Diabetic Skin and Wound Healing Diabetes mellitus is a chronic condition marked by elevated blood glucose levels due to abnormal insulin production or insulin... Aug 14 Is Micro-Botox Disrupting the Skin's Microbiome Balance? Micro-Botox is a specialised technique involving the injecting of diluted botulinum toxin into the skin. It is a frequently performed... Aug 9 Skin Microbiome Could Snail Mucin Be the Secret to a Thriving Skin Microbiome? Snail mucin is the secretion produced by various species of snails, and it has recently gained attention for its potential benefits in... Aug 9 Oral Microbiome Igniting Inquiry: Unravelling Smoking's Impact on the Oral Microbiome While the harmful effects of smoking on overall health are widely recognised, its impact on the oral microbiome is still not fully... Aug 2 Skin Microbiome Don't Sweat It: How Deodorant Disrupts Your Underarm Microbiome The underarm (axillary) microbiome plays a crucial role in body odour production. Although deodorants and fragranced cosmetic products... Aug 1 Skin Microbiome Mosquitoes vs. Microbes: Can Your Skin's Secret Agents Defend Against Malaria? Malaria remains one of the deadliest diseases of the last century, posing a significant global health challenge. Researchers are... Jul 22 Skin Microbiome The Microbial Mysteries of Sensitive Skin: Unveiling the Microbiome's Role Sensitive skin (SS), also known as cutaneous sensory syndrome, is characterised by abnormal hypersensitivity to various stimuli, leading... Jul 5 Scalp Microbiome Unlocking the Power of Rosemary Oil: Is This A Natural Solution for Scalp Health? Rosemary oil has become increasingly popular in the hair care cosmetics industry, praised for its potential to improve scalp health and... Jun 28 Skin Microbiome The Hidden Changes: How Does Ageing Transform Our Skin Microbiome? Although the ageing process is complex and individualised, research highlights the significant role of the skin microbiome in skin... Jun 25 White Papers Artificial Intelligence: Decoding the Microbiome or Complicating It? The skin microbiome, a complex ecosystem of bacteria, fungi, viruses, and other microorganisms living on our skin, plays a crucial role... Jun 21 Oral Microbiome More Than Just the Mouth: Therapeutic Insights Into the Oral Microbiome's Role in Alzheimer's Disease Alzheimer's disease (AD) is a progressive neurodegenerative condition characterised by memory loss, changes in personality and behaviour... Jun 19 Skin Microbiome Understanding the Gut-Skin Axis Both the gut and skin are colonised with distinct microbial communities and operate as crucial organs in the body. Jun 19 Skin Microbiome Understanding Skin Ageing Skin ageing is a natural and inevitable process caused by structural and functional changes in skin cells due to intrinsic and extrinsic fac Jun 19 Skin Microbiome Understanding Atopic Dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a common chronic inflammatory skin condition that is characterised by inflamed, dry Jun 19 Skin Microbiome Acne & The Skin Microbiome? Acne is a well-known chronic inflammatory condition that impacts individuals of all age groups worldwide. Jun 19 Skin Microbiome Illuminating the Skin: The Influence of LED Masks on the Skin Microbiome In the world of skincare, light-emitting diode (LED) technology has emerged as a powerful tool, emitting specific wavelengths of light,... Jun 14 Scalp Microbiome Exploring the Intricacies of Scalp and Hair Microbiomes: Unveiling Host Factors and Industry Implications The scalp hair shaft microbiota is distinct from that of the scalp skin. Jun 14 Skin Microbiome What Role Does the Skin Microbiome Play in the Complex Process of Wound Healing? The interplay between skin wounds and the skin microbiome presents a captivating area of study. May 17 Scalp Microbiome Unveiling the Enigma of Fungal Acne: How Does the Skin Microbiome Cause Malassezia Folliculitis? Often colloquially termed "fungal acne," Malassezia folliculitis (MF) is an infection of the hair follicle triggered by yeasts belonging to May 17 Vaginal Microbiome Delving into Feminine Wellness: Redefining Intimate Care with the Vulvar Microbiome While our understanding of the microbial composition of the vulva is still evolving, it holds the potential to maintain overall genital heal May 17 Skin Microbiome How Does the Skin Microbiome Influence Rosacea? Unveiling the Microbial Puzzle Rosacea, a chronic inflammatory skin condition, involves complex interactions between the skin microbiota and host conditions. 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The Skin Microbiome Review All Posts White Papers Skin Microbiome Scalp Microbiome Vaginal Microbiome Oral Microbiome Baby Microbiome 33 minutes ago Skin Microbiome Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised... 6 days ago Skin Microbiome Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced... Aug 21 Scalp Microbiome Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on... Aug 16 Skin Microbiome Diabetes Dilemma: The Skin Microbiome’s Influence on Diabetic Skin and Wound Healing Diabetes mellitus is a chronic condition marked by elevated blood glucose levels due to abnormal insulin production or insulin... Aug 14 Is Micro-Botox Disrupting the Skin's Microbiome Balance? Micro-Botox is a specialised technique involving the injecting of diluted botulinum toxin into the skin. It is a frequently performed... Aug 9 Skin Microbiome Could Snail Mucin Be the Secret to a Thriving Skin Microbiome? Snail mucin is the secretion produced by various species of snails, and it has recently gained attention for its potential benefits in... Aug 9 Oral Microbiome Igniting Inquiry: Unravelling Smoking's Impact on the Oral Microbiome While the harmful effects of smoking on overall health are widely recognised, its impact on the oral microbiome is still not fully... Aug 2 Skin Microbiome Don't Sweat It: How Deodorant Disrupts Your Underarm Microbiome The underarm (axillary) microbiome plays a crucial role in body odour production. Although deodorants and fragranced cosmetic products... Aug 1 Skin Microbiome Mosquitoes vs. Microbes: Can Your Skin's Secret Agents Defend Against Malaria? Malaria remains one of the deadliest diseases of the last century, posing a significant global health challenge. Researchers are... Jul 22 Skin Microbiome The Microbial Mysteries of Sensitive Skin: Unveiling the Microbiome's Role Sensitive skin (SS), also known as cutaneous sensory syndrome, is characterised by abnormal hypersensitivity to various stimuli, leading... Jul 5 Scalp Microbiome Unlocking the Power of Rosemary Oil: Is This A Natural Solution for Scalp Health? Rosemary oil has become increasingly popular in the hair care cosmetics industry, praised for its potential to improve scalp health and... Jun 28 Skin Microbiome The Hidden Changes: How Does Ageing Transform Our Skin Microbiome? Although the ageing process is complex and individualised, research highlights the significant role of the skin microbiome in skin... Jun 25 White Papers Artificial Intelligence: Decoding the Microbiome or Complicating It? The skin microbiome, a complex ecosystem of bacteria, fungi, viruses, and other microorganisms living on our skin, plays a crucial role... Jun 21 Oral Microbiome More Than Just the Mouth: Therapeutic Insights Into the Oral Microbiome's Role in Alzheimer's Disease Alzheimer's disease (AD) is a progressive neurodegenerative condition characterised by memory loss, changes in personality and behaviour... Jun 19 Skin Microbiome Understanding the Gut-Skin Axis Both the gut and skin are colonised with distinct microbial communities and operate as crucial organs in the body. Jun 19 Skin Microbiome Understanding Skin Ageing Skin ageing is a natural and inevitable process caused by structural and functional changes in skin cells due to intrinsic and extrinsic fac Jun 19 Skin Microbiome Understanding Atopic Dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a common chronic inflammatory skin condition that is characterised by inflamed, dry Jun 19 Skin Microbiome Acne & The Skin Microbiome? Acne is a well-known chronic inflammatory condition that impacts individuals of all age groups worldwide. Jun 19 Skin Microbiome Illuminating the Skin: The Influence of LED Masks on the Skin Microbiome In the world of skincare, light-emitting diode (LED) technology has emerged as a powerful tool, emitting specific wavelengths of light,... Jun 14 Scalp Microbiome Exploring the Intricacies of Scalp and Hair Microbiomes: Unveiling Host Factors and Industry Implications The scalp hair shaft microbiota is distinct from that of the scalp skin. Jun 14 Skin Microbiome What Role Does the Skin Microbiome Play in the Complex Process of Wound Healing? The interplay between skin wounds and the skin microbiome presents a captivating area of study. May 17 Scalp Microbiome Unveiling the Enigma of Fungal Acne: How Does the Skin Microbiome Cause Malassezia Folliculitis? Often colloquially termed "fungal acne," Malassezia folliculitis (MF) is an infection of the hair follicle triggered by yeasts belonging to May 17 Vaginal Microbiome Delving into Feminine Wellness: Redefining Intimate Care with the Vulvar Microbiome While our understanding of the microbial composition of the vulva is still evolving, it holds the potential to maintain overall genital heal May 17 Skin Microbiome How Does the Skin Microbiome Influence Rosacea? Unveiling the Microbial Puzzle Rosacea, a chronic inflammatory skin condition, involves complex interactions between the skin microbiota and host conditions.