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Dandruff Study with Sequential's Cutting-Edge Microbiome Testing
Why Microbiome Testing for Dandruff?
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Dandruff is a widespread issue, affecting nearly 50% of the global population (American Academy of Dermatology). This condition is often linked to the overgrowth of Malassezia, a yeast that naturally lives on the scalp. When imbalances occur in the scalp microbiome, it can lead to an increase in dandruff symptoms, including flaking and itching. While dandruff is not dangerous, it can significantly affect a person's confidence and quality of life.
Given the complex relationship between dandruff and the scalp microbiome, in vivo testing of shampoos and scalp care products is crucial. Products designed to treat dandruff must be tested on real individuals to assess their impact on microbial populations and ensure they effectively target the underlying causes without disrupting the scalp's natural ecosystem​
Sequential is leading the way in microbiome testing for the industry. With a specialized focus on scalp conditions, we have developed an innovative solution tailored to help you understand the root causes of dandruff at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of dandruff-associated microbiota, giving you the tools to transform skincare solutions.
Customized Analysis
Tailored insights specific to dandruff, allowing your R&D team to develop more personalized and effective products.
Actionable Data
Leverage detailed reports to guide formulation decisions and validate product efficacy with precision.
Product Innovation
New dandruff treatments or enhancing existing lines, our data helps you create targeted solutions with proven results.
Precision Sequencing
Target specific microbial communities associated with dandruff development and severity.
Smart Probes™
Our dedicated team of scientists has developed a groundbreaking method for evaluating microbes through our Smart Probes™, a proprietary panel featuring 23 key microbes specifically identified as having the greatest impact on scalp health, particularly in relation to dandruff. To further explore the intricate connection between dandruff and the scalp microbiome, we employ qPCR technology. This cutting-edge technique enables us to precisely measure microbial populations on the scalp, providing a clearer understanding of how imbalances—such as the overgrowth of Malassezia fungi—can contribute to dandruff. By carefully analyzing how haircare products interact with both beneficial and dandruff-causing microbes, companies can develop solutions that not only target flaking and itching but also support a healthier, balanced scalp microbiome, promoting long-term scalp health and reducing dandruff recurrence.
Dandruff Panel Targets
Malassezia globosa
Cutibacterium acnes and Malassezia globosa are found to be negatively correlated to dandruff parameters.
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​Malassezia restricta
Malassezia restricta is a fungus that is more common in people with dandruff than in healthy people
Pseudomonas nitroreducens
A bacteria that is more common in people with dandruff than in healthy people
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Tao R, Li R, Wang R. Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review. Exp Dermatol. 2021 Oct;30(10):1546-1553. doi: 10.1111/exd.14450. Epub 2021 Aug 27. PMID: 34415635.
Industry Leader in Absolute Quantification
Sequential’s Smart Probe™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches.
